Effects of activity dependent plasticity on recovery of bladder and sexual function after human spinal cord injury
活动依赖性可塑性对人脊髓损伤后膀胱和性功能恢复的影响
基本信息
- 批准号:10228656
- 负责人:
- 金额:$ 38.23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-09-23 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAnodesAtrial Natriuretic FactorAttenuatedAutonomic DysfunctionAutonomic DysreflexiaBiological MarkersBladderBlood PressureCardiovascular PhysiologyCardiovascular systemCaringCatheterizationCathodesCervicalChestChillsDataElectrodesEventFeedbackFrequenciesGoalsGuidelinesHeadacheHeart RateHomeHome environmentHomeostasisHormonesHumanHypertensionHypotensionIndividualInternationalIntestinesLaboratoriesLesionLocationMaintenanceManometryMeasuresMonitorNorepinephrineOutcomeParticipantPersonsPhysiologicalPiloerectionPopulationQuality of lifeQuestionnairesRecoveryRectumReflex actionReninReportingResearchSeveritiesSex FunctioningSignal TransductionSocietiesSpinal CordSpinal cord injurySymptomsSystemTension HeadacheTherapeuticTimeTrainingUrodynamicsVasopressinsVisceralabdominal pressurebaseblood pressure regulationimprovedindexingmobile applicationmultidisciplinarypressurepreventprogramspsychologicrectalresponsetime intervalurinaryvasoconstrictionvoltage
项目摘要
Abstract
Bladder and bowel complications have consistently been rated as of the upmost importance by
the spinal cord injury (SCI) population. Importantly, both bladder and bowel distention have
been identified as primary triggers of autonomic dysreflexia (AD) in individuals with cervical and
upper thoracic level lesions (majority of SCI population), a systolic blood pressure rising often
more than 20 mmHg and remaining at these values with intolerable symptoms (pounding
headache and/or chills, for example). We have recently documented as part of our current R01
this massive unmodulated sympathetic reflex which causes widespread vasoconstriction
(presenting as severe hypertension) as a limitation for bladder capacity in numerous research
participants. Anecdotally, many who use clean intermittent catheterization for bladder
management report using AD symptoms daily as a signal of bladder fullness and time for
emptying, an unsafe practice that needs addressing. Additionally, we and others have
documented in questionnaires regular occurrences of AD symptoms during bowel programs and
in ongoing lab-based studies there have been numerous instances of AD upon insertion of a
rectal probe either for bladder cystometry (for recording abdominal pressure) or during anorectal
manometry. The goals of the current multi-disciplinary study incorporating critical cross viscero-
visceral intersystem interactions are 1) to investigate in a controlled laboratory setting and then
with mobile at-home monitoring the extent, severity and frequency of occurrence of AD with
respect to daily bladder and bowel function, in conjunction with identifying potential underlying
mechanisms by examining urinary biomarkers for several specific vasoactive hormones, and 2)
to regulate cardiovascular (CV) function therapeutically as part of bladder and bowel
management using spinal cord epidural stimulation, which our CV team have shown can
normalize blood pressure.
抽象的
膀胱和肠并发症一直被评为最重要的。
脊髓损伤(SCI)人群。重要的是,膀胱和肠延伸都有
被确定为宫颈和宫颈和
上胸腔水平病变(大多数SCI人群),经常升高
超过20 mmHg,并在这些值下保持无法忍受的症状(重击
例如,头痛和/或发冷)。我们最近记录了当前R01的一部分
这种巨大的未经调节的交感反射会导致广泛的血管收缩
(以严重的高血压表示)作为膀胱容量的限制
参与者。有趣的是,许多使用干净的间歇性导管插入膀胱的人
每天使用广告症状的管理报告是膀胱饱满的信号和时间
排空,一种不安全的练习,需要解决。此外,我们和其他人都有
记录在问卷中经常出现在排便过程中的AD症状和
在正在进行的基于实验室的研究中,插入时有许多AD实例
直肠探针要么用于膀胱囊肿(用于记录腹压)或肛门直肠压力
测量法。当前的多学科研究的目标包括关键的跨内脏 -
内脏间间相互作用是1)在受控的实验室环境中进行调查,然后
随着移动监控,AD的发生程度,严重程度和频率
尊重每日膀胱和肠功能,结合识别潜在的潜在
通过检查几种特定的血管活性激素的尿生物标志物和2)的机制,2)
作为膀胱和肠的一部分,在治疗上调节心血管(CV)功能
使用脊髓硬膜外刺激的管理,我们的简历团队表明可以
使血压归一化。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('SUSAN J HARKEMA', 18)}}的其他基金
Functional Mapping with Lumbosacral Epidural Stimulation for Restoration of Bladder Function After Spinal Cord Injury
腰骶部硬膜外刺激功能标测用于脊髓损伤后膀胱功能的恢复
- 批准号:
10455251 - 财政年份:2017
- 资助金额:
$ 38.23万 - 项目类别:
Functional Mapping with Lumbosacral Epidural Stimulation for Restoration of Bladder Function After Spinal Cord Injury
腰骶部硬膜外刺激功能标测用于脊髓损伤后膀胱功能的恢复
- 批准号:
10005625 - 财政年份:2017
- 资助金额:
$ 38.23万 - 项目类别:
Effects of activity dependent plasticity on recovery of bladder and sexual function after human spinal cord injury
活动依赖性可塑性对人脊髓损伤后膀胱和性功能恢复的影响
- 批准号:
10663193 - 财政年份:2014
- 资助金额:
$ 38.23万 - 项目类别:
Effects of activity dependent plasticity on recovery of bladder and sexual function after human spinal cord injury
活动依赖性可塑性对人脊髓损伤后膀胱和性功能恢复的影响
- 批准号:
10453771 - 财政年份:2014
- 资助金额:
$ 38.23万 - 项目类别:
Effects of activity dependent plasticity on recovery of bladder and sexual function after human spinal cord injury
活动依赖性可塑性对人脊髓损伤后膀胱和性功能恢复的影响
- 批准号:
9093814 - 财政年份:2014
- 资助金额:
$ 38.23万 - 项目类别:
PLASTICITY OF HUMAN SPINAL NEURAL NETWORKS AFTER INJURY
人类脊髓神经网络受伤后的可塑性
- 批准号:
7955656 - 财政年份:2009
- 资助金额:
$ 38.23万 - 项目类别:
PLASTICITY OF HUMAN SPINAL NEURAL NETWORKS AFTER INJURY
人类脊髓神经网络受伤后的可塑性
- 批准号:
7724333 - 财政年份:2008
- 资助金额:
$ 38.23万 - 项目类别:
CORE--DATA PROCESSING AND BIOSTATISTICAL CORE
核心——数据处理和生物统计核心
- 批准号:
7436281 - 财政年份:2007
- 资助金额:
$ 38.23万 - 项目类别:
ACTIVITY DEPENDENT PLASTICITY AFTER HUMAN SPINAL CORD INJURY
人类脊髓损伤后的活动依赖性可塑性
- 批准号:
7436279 - 财政年份:2007
- 资助金额:
$ 38.23万 - 项目类别:
PLASTICITY OF HUMAN SPINAL NEURAL NETWORKS AFTER INJURY
人类脊髓神经网络受伤后的可塑性
- 批准号:
7627689 - 财政年份:2007
- 资助金额:
$ 38.23万 - 项目类别:
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