Clinical Core

临床核心

基本信息

批准号：
10406868
负责人：
HILLEL GROSSMAN
金额：
$ 135.88万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10406868
关键词：
Affect Age Alzheimer&apos s Disease Assessment tool Attention Autopsy Biological Biological Markers Brain Clinical Clinical Data Clinical Research Clinical Trials Cognition Cognition Disorders Cognitive Collaborations Communities Cultural Diversity DNA Data Data Collection Data Set Dementia Development Diagnostic Disease Elderly Ensure Ethnic Origin Evaluation Fostering Frequencies Genetic Genotype Goals Health system Heterogeneity Imaging technology Impaired cognition Impairment Individual Industry Institution Intervention Studies Ligands Methods Minority Groups Minority Participation Neuropsychology Normal Range Observational Study Participant Patients Phenotype Physicians Population Positron-Emission Tomography Postdoctoral Fellow Procedures Protocols documentation Race Recording of previous events Registries Research Research Personnel Research Subjects Research Technics Resources Risk Role Sampling Services Side Specific qualifier value Specimen Standardization Techniques Tissues Training Underrepresented Populations United States National Institutes of Health Work biomarker development clinical biomarkers clinical material clinical phenotype clinical translation cognitive testing cohort cooperative study data sharing design disorder risk doctoral student ethnic diversity follow-up genome-wide high standard imaging biomarker innovation instrument interest mild cognitive impairment neuroimaging neuropathology normal aging novel outreach patient population pre-clinical programs recruit resilience screening treatment response

项目摘要

Mount Sinai ADRC (Sano): Clinical Core (Core B) – Research Summary The Clinical Core provides expertise in the clinical and biological characterization of individuals with cognitive loss and dementia and the ability to identify non-impaired older individuals. This expertise is utilized to recruit and maintain a cohort of participants of varying ages, clinical presentations, educational attainment, races and ethnicities. This well-characterized cohort supports a broad array of dementia and cognitive research conducted within the ISMMS, the Mount Sinai Health System (MSHS,) and national initiatives such as the National Alzheimer's Coordinating Center (NACC), the Genome Wide Alzheimer's Study (GWAS), Alzheimer's Disease Cooperative Studies (ADCS), and the Alzheimer's Disease Neuroimaging Initiative (ADNI). The role of the core is to develop and implement clinical procedures and collect biomarkers for the high standard characterization of elders spanning the spectrum of normal, prodromal, and various stages of affected subjects into “research-ready” cohorts. The Clinical Core provides subjects, tissue, and data for studies as well as clinical research expertise related to clinical manifestations of disease, disease course, treatment responses, and recruitment feasibility to help guide the design and implementation of studies within the Center and broadly within the MSHS. Within the Center, the Clinical Core provides the essentials for research: the subjects and their clinical characterization to participate in the Biomarker and Genetics Cores; the clinical characterization of brain donations and other specimens disseminated to the Neuropathology Core; clinical and educational expertise to interact with the projects and trainees of the ORE and REC cores. The Core innovates in the development of assessment tools; application of assessments to new populations; adaptation of new imaging technologies into the clinical `real world'; and clinical trials of novel, under-studied or repurposed compounds. The Core has a rich and successful history of outreach to groups underrepresented in dementia research and provisions to continue this are built into this application. The Core is active in training young investigators and supporting investigators from other fields who wish to study cognition in their clinical populations.

西奈山ADRC（SANO）：临床核心（核心B） - 研究摘要临床核心在认知个体的临床和生物学表征方面提供了专业知识损失和痴呆症以及识别未受影响的老年人的能力。该专业知识用于招募并保持各个年龄段，临床演示，教育成就，种族和种族的参与者队伍种族。这种良好的人群支持了广泛的痴呆和认知研究在ISMM，西奈山卫生系统（MSHS）和国家倡议中进行的阿尔茨海默氏症国家协调中心（NACC），基因组广泛的阿尔茨海默氏症研究（GWAS），阿尔茨海默氏症疾病合作研究（ADC）和阿尔茨海默氏病神经影像学倡议（ADNI）。的作用核心是制定和实施临床程序并为高标准收集生物标志物跨越正常，前驱和各个阶段的长者的表征进入“准备研究”的同伙。临床核心提供研究的受试者，组织和数据以及临床研究专业知识与疾病，疾病病程，治疗反应的临床表现有关，以及招聘可行性，可帮助指导中心内的研究设计和实施在MSH中。在中心内，临床核心为研究提供了必需因素：受试者和他们参与生物标志物和遗传学核心的临床表征；的临床表征大脑捐赠和其他标本传播到神经病理学核心；临床和教育与矿石和娱乐核心的项目和培训互动的专业知识。核心创新开发评估工具；对新人群的评估应用；改编新成像进入临床“现实世界”的技术；以及新型，研究不足或重新利用化合物的临床试验。该核心在痴呆症研究中所占的群体不足，拥有丰富而成功的历史继续此操作的规定已内置在本应用程序中。核心积极培训年轻调查员和支持其他希望研究临床人群认知的研究者。