Transition from Acute to Chronic Pain in Total Knee Arthroplasty Patients: Identifying Resilience and Vulnerability Profiles
全膝关节置换术患者从急性疼痛到慢性疼痛的转变:确定恢复力和脆弱性概况
基本信息
- 批准号:10231116
- 负责人:
- 金额:$ 289.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-15 至 2024-07-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAcute PainAppearanceBiologicalChicagoChronicClinicalDataData SetDegenerative polyarthritisDiagnostic radiologic examinationDisabled PersonsElderlyFundingGenerationsGoalsHealth systemHelping to End Addiction Long-termIllinoisImageInstitutesInternationalKnee OsteoarthritisOperative Surgical ProceduresPainPatientsPersistent painPostoperative PainPrevention strategyProceduresProcessProviderReplacement ArthroplastyResearchResearch Project GrantsTranslational ResearchUnited StatesUnited States National Institutes of HealthUniversitieschronic paindata integrationdata resourcedisabilityexperiencefunctional outcomesknee replacement arthroplastymiddle agepain reliefpatient orientedpatient populationprogramspsychologicracial and ethnicresearch studyresiliencesocioeconomicstranslational medicinetreatment strategy
项目摘要
Project Summary/Abstract
Osteoarthritis (OA) is the single most important cause of disability in mid and late life. About 27 million
people in the United States suffer from this incurable process and 10 million have OA of the knee. Total knee
arthroplasty (TKA) is a reliable treatment option for patients disabled by knee OA who have failed nonoperative
treatment, with 58% of these surgeries being performed on patients 65 years or older. TKA surgeries were
performed on more than 700,000 patients in the United States in 2012 and estimates expect this number to
increase between 143% and 565% by 2050. Most patients experience pain relief within 6 to 12 weeks
following TKA; however, 8 to 34% of patients experience chronic postsurgical pain, defined by the International
Association for the Study of Pain as clinically important pain lasting more than 3 months after surgery, with
limited improvement in functional outcomes often despite an uneventful surgical course and a satisfactory
radiographic appearance. With one projected estimate of 3.48 million TKA surgeries per year in the USA by
2030, up to 500,000 patients annually could develop chronic pain following TKA. The objective of this project is
to aid in the construction of a dataset that encompasses clinical, biological (omics), psychological,
socioeconomical and imaging predictors for a diverse group of patients undergoing TKA. Rush University the
largest provider of joint replacement surgery in Illinois, performing 2,100 TKA procedures in 2017. With our
Institute for Translational Medicine (ITM) partners, the University of Chicago, and NorthShore University Health
System our NCATS CTSA-funded program hub has extensive translational research expertise and serves a
diverse patient population (>5 million) across many racial, ethnic and socioeconomic strata and collectively
perform more than 4000 TKA procedures per year. The overall project goal of the proposed research study is
to provide high fidelity clinical, biological and psychological data in conjunction with Clinical Coordination
Center, the Data Integration and Resource Center, and the Omics Data Generation Center from patients
undergoing TKA within our NCATS CTSA-funded program hub in line with NIH HEAL Initiative A2CPS. This
information should enrich our understanding of how acute pain becomes chronic pain following surgery and
enhance our ability to target effective preventive and treatment strategies for patients.
项目概要/摘要
骨关节炎(OA)是导致中晚年残疾的最重要的单一原因。约2700万
在美国,有 1000 万人患有这种无法治愈的疾病,其中有 1000 万人患有膝骨关节炎。全膝关节
对于非手术治疗失败的膝骨关节炎致残患者来说,关节置换术 (TKA) 是一种可靠的治疗选择
治疗,其中 58% 的手术是针对 65 岁或以上的患者进行的。 TKA 手术是
2012 年,美国对超过 700,000 名患者进行了治疗,预计这一数字将
到 2050 年,这一数字将增加 143% 至 565%。大多数患者在 6 至 12 周内疼痛得到缓解
全膝关节置换术后;然而,根据国际组织的定义,8% 至 34% 的患者会经历慢性术后疼痛。
疼痛研究协会认为手术后持续超过 3 个月的临床重要疼痛,
尽管手术过程顺利且令人满意,但功能结果的改善往往有限
射线照相外观。据预测,美国每年进行 348 万次 TKA 手术
到 2030 年,每年将有多达 500,000 名患者在 TKA 后可能出现慢性疼痛。该项目的目标是
帮助构建涵盖临床、生物学(组学)、心理学、
接受 TKA 的不同患者群体的社会经济和影像学预测因素。拉什大学
伊利诺伊州最大的关节置换手术提供商,2017 年实施了 2,100 例 TKA 手术。
转化医学研究所 (ITM) 合作伙伴、芝加哥大学和北岸大学健康中心
我们的 NCATS CTSA 资助的系统项目中心拥有广泛的转化研究专业知识,并为
不同种族、民族和社会经济阶层的不同患者群体(>500万)
每年执行超过 4000 例 TKA 手术。拟议研究的总体项目目标是
结合临床协调提供高保真度的临床、生物学和心理数据
中心、数据集成和资源中心以及患者组学数据生成中心
根据 NIH HEAL Initiative A2CPS 在我们的 NCATS CTSA 资助的项目中心内接受 TKA。这
信息应该丰富我们对手术后急性疼痛如何变成慢性疼痛的理解
增强我们为患者制定有效预防和治疗策略的能力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John W. Burns其他文献
The effects of telehealth-delivered mindfulness meditation, cognitive therapy, and behavioral activation for chronic low back pain: a randomized clinical trial
远程医疗提供的正念冥想、认知疗法和行为激活对慢性腰痛的影响:一项随机临床试验
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:9.3
- 作者:
M. Day;Marcia A. Ciol;M. E. Mendoza;Jeffrey Borckardt;D. Ehde;Andrea K Newman;J. Chan;Sydney A. Drever;Janna L Friedly;John W. Burns;Beverly E. Thorn;Mark P. Jensen - 通讯作者:
Mark P. Jensen
Treating a common comorbidity: Pain outcomes following a 3-week cognitive processing therapy-based intensive treatment for posttraumatic stress disorder address.
治疗常见合并症:针对创伤后应激障碍进行为期 3 周的基于认知处理疗法的强化治疗后的疼痛结果。
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:3.3
- 作者:
Merdijana Kovacevic;Mauricio Montes;Vanessa Tirone;Sarah Pridgen;Dale L. Smith;John W. Burns;Philip Held - 通讯作者:
Philip Held
Antiidiotype modulation of herpes simplex virus infection leading to increased pathogenicity
单纯疱疹病毒感染的抗独特型调节导致致病性增加
- DOI:
10.1128/jvi.50.3.951-953.1984 - 发表时间:
1984 - 期刊:
- 影响因子:5.4
- 作者:
Ronald C. Kennedy;Karen Adler;John W. Burns;Richard D. Henkel;G. Dreesman - 通讯作者:
G. Dreesman
John W. Burns的其他文献
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{{ truncateString('John W. Burns', 18)}}的其他基金
Comparative Mechanisms (Mediators, Moderators) of Psychosocial Chronic Pain Treatments
社会心理慢性疼痛治疗的比较机制(中介、调节因素)
- 批准号:
10710208 - 财政年份:2022
- 资助金额:
$ 289.12万 - 项目类别:
Comparative Mechanisms (Mediators, Moderators) of Psychosocial Chronic Pain Treatments
社会心理慢性疼痛治疗的比较机制(中介、调节因素)
- 批准号:
10810951 - 财政年份:2022
- 资助金额:
$ 289.12万 - 项目类别:
Transition from Acute to Chronic Pain in Total Knee Arthroplasty Patients: Identifying Resilience and Vulnerability Profiles
全膝关节置换术患者从急性疼痛到慢性疼痛的转变:确定恢复力和脆弱性概况
- 批准号:
10593786 - 财政年份:2022
- 资助金额:
$ 289.12万 - 项目类别:
Comparative Mechanisms (Mediators, Moderators) of Psychosocial Chronic Pain Treatments
社会心理慢性疼痛治疗的比较机制(中介、调节因素)
- 批准号:
10564263 - 财政年份:2022
- 资助金额:
$ 289.12万 - 项目类别:
Transition from Acute to Chronic Pain in Total Knee Arthroplasty Patients: Identifying Resilience and Vulnerability Profiles
全膝关节置换术患者从急性疼痛到慢性疼痛的转变:确定恢复力和脆弱性概况
- 批准号:
9812647 - 财政年份:2019
- 资助金额:
$ 289.12万 - 项目类别:
Development of Co-Morbid PTSD and Chronic Pain Among Inner-City Women
内城区女性共病创伤后应激障碍 (PTSD) 和慢性疼痛的发展
- 批准号:
9095272 - 财政年份:2015
- 资助金额:
$ 289.12万 - 项目类别:
Development of Co-Morbid PTSD and Chronic Pain Among Inner-City Women
内城区女性共病创伤后应激障碍 (PTSD) 和慢性疼痛的发展
- 批准号:
9490306 - 财政年份:2015
- 资助金额:
$ 289.12万 - 项目类别:
Mechanisms of Psychosocial Chronic Pain Treatments
社会心理慢性疼痛治疗机制
- 批准号:
9130041 - 财政年份:2013
- 资助金额:
$ 289.12万 - 项目类别:
Mechanisms of Psychosocial Chronic Pain Treatments
社会心理慢性疼痛治疗机制
- 批准号:
8740557 - 财政年份:2013
- 资助金额:
$ 289.12万 - 项目类别:
Mechanisms of Psychosocial Chronic Pain Treatments
社会心理慢性疼痛治疗机制
- 批准号:
8880001 - 财政年份:2013
- 资助金额:
$ 289.12万 - 项目类别:
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