Quantitative PET/MRI of brain oxygenation in cerebrovascular disease

脑血管疾病脑氧合定量 PET/MRI

• 批准号: 10401486
• 负责人: Audrey Peiwen Fan
• 金额: $ 22.28万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-15 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10401486
• 关键词: Acetazolamide; Address; Affect; Biological; Biological Markers; Blood; Blood Vessels; Blood capillaries; Brain; Brain imaging; Carotid Stenosis; Cause of Death; Cerebrovascular Disorders; Cerebrum; Clinical; Collaborations; Communities; Complex; Consensus; Consumption; Development; Diagnosis; Dictionary; Disease; Equipment; Fingerprint; Functional disorder; Gases; Hospitals; Human; Hybrids; Image; Imaging Device; Imaging Techniques; Impairment; Inhalation; Injections; Institution; Intervention; Lead; Magnetic Resonance Imaging; Magnetism; Maps; Measurement; Measures; Medical; Metabolic; Metabolism; Methods; Modeling; Moyamoya Disease; Multicenter Trials; Nerve Degeneration; Neurologist; Neurosurgeon; Outcome; Oxygen; Patients; Perfusion; Persons; Physiologic pulse; Physiological; Physiology; Population; Positron-Emission Tomography; Predisposition; Procedures; Protocols documentation; Reference Standards; Relaxation; Reproducibility; Research Personnel; Resolution; Rest; Sagittal Sinus; Sampling; Scanning; Signal Transduction; Stenosis; Stroke; Stroke prevention; Surgeon; Symptoms; Techniques; Tissue Extracts; Tissue Viability; Tissue imaging; Tissues; Tracer; Traumatic Brain Injury; United States; Validation; Vasodilator Agents; Venous; Water; Work; acute stroke; base; biophysical model; blood oxygen level dependent; brain magnetic resonance imaging; brain tissue; cerebral oxygenation; cerebrovascular; clinical research site; cohort; deoxyhemoglobin; design; disability; healthy volunteer; high risk; imaging approach; imaging modality; imaging study; imaging system; improved; in vivo; innovation; insight; nervous system disorder; non-invasive imaging; novel; novel imaging technique; patient stratification; radiotracer; spatiotemporal; stroke outcome; stroke recovery; stroke risk; tissue mapping; tissue oxygenation; tool; tumor

Stroke is a leading cause of death and disability and creates a societal burden of $34 billion each year in the United States alone. While new endovascular treatments have shown promise to improve stroke outcomes and recovery, they have been hampered by the lack of noninvasive biomarkers to identify patients who are good candidates for these therapies. In particular, imaging of brain oxygenation is a long-recognized but unmet need in the stroke community, and we propose to use magnetic resonance imaging (MRI) to address this need. This project develops a clinically feasible toolset to noninvasively image brain tissue oxygenation by magnetic resonance imaging. Our specific aims are (1) to develop new MRI techniques, quantitative BOLD and vascular fingerprinting, that utilize a novel pulse sequence to quantify oxygen extraction fraction (OEF) levels in cerebral tissues; (2) to validate MR OEF imaging with simultaneous [15O] positron emission tomography (PET) reference images in patients with cerebrovascular disease; and (3) to apply MRI OEF methods to study oxygenation status in patients with carotid artery stenosis who are at high risk of stroke. The innovation of this work lies in the development of a novel imaging technique to assess quantitative OEF in brain tissues. The use of a hybrid PET/MRI system to validate the new OEF imaging methods with simultaneous measurements by [15O] PET is also highly novel. The outcome of proposal is a validated MRI tool to image OEF, and quantitative MRI observations of OEF in patients with carotid artery stenosis, and its relationship to patient symptoms and perfusion status. The significance of this work is a clinically feasible MRI protocol to image tissue OEF that is transferrable to any clinical site. The reproducible and robust tool will allow the stroke imaging community to better stratify patients for new treatments, and implement multi-center trials to evaluate endovascular interventions to reduce stroke risk in these populations.

中风是死亡和残疾的主要原因，仅在美国，每年就会产生340亿美元的社会负担。尽管新的血管内治疗表现出有望改善中风结果和康复的希望，但由于缺乏无创生物标志物无法识别那些良好候选这些疗法的患者而受到阻碍。特别是，在中风社区中，脑充氧的成像是一种长期认识但未满足的需求，我们建议使用磁共振成像（MRI）来满足这一需求。 该项目通过磁共振成像开发了一种临床上可行的刀具，以非侵入性地图像脑组织氧合。我们的具体目的是（1）开发新的MRI技术，定量粗体和血管指纹识别，该技术利用了新型的脉冲序列来量化大脑组织中的氧气提取分数（OEF）水平； （2）用同时[15O]正电子发射断层扫描（PET）参考图像验证MR OEF成像。 （3）应用MRI OEF方法来研究中风高风险的颈动脉狭窄患者的氧合状态。 这项工作的创新在于开发一种新型成像技术，以评估脑组织中的定量OEF。使用杂交宠物/MRI系统通过[15O] PET同时测量的新OEF成像方法也很新颖。提案的结果是对OEF进行验证的MRI工具，并且对颈动脉狭窄患者的OEF进行了定量的MRI观察，及其与患者症状和灌注状况的关系。这项工作的重要性是一种在临床上可行的MRI方案，可对组织OEF进行图像可转移到任何临床部位的组织OEF。可再现和健壮的工具将使中风成像群落可以更好地分类患者的新治疗方法，并实施多中心试验以评估血管内干预措施，以减少这些人群中的中风风险。

项目成果

Short- and Long-Term MRI Assessed Hemodynamic Changes in Pediatric Moyamoya Patients After Revascularization.

• DOI: 10.1002/jmri.28902
• 发表时间: 2023-07
• 期刊: Journal of Magnetic Resonance Imaging
• 影响因子: 4.4
• 作者: Moss Y. Zhao;Elizabeth Tong;Rui Duarte Armindo;Ates Fettahoglu;Jason J. Choi;Jacob Bagley;K. Yeom;Mike E Moseley;G. Steinberg;G. Zaharchuk

Dynamic Magnetic Resonance Vascular Fingerprinting During Hypercapnia for Quantitative and Multiparametric Cerebrovascular Reactivity Measures.

高碳酸血症期间的动态磁共振血管指纹图谱用于定量和多参数脑血管反应性测量。

• DOI: 10.1109/embc40787.2023.10339967
• 发表时间: 2023
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Wheeler,GregoryJ;Lee,QuimbyN;Fan,AudreyP
• 通讯作者: Fan,AudreyP

Modeling venous bias in resting state functional MRI metrics.

• DOI: 10.1002/hbm.26431
• 发表时间: 2023-10-01
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Huck, Julia;Jaeger, Anna-Thekla;Schneider, Uta;Grahl, Sophia;Fan, Audrey P.;Tardif, Christine;Villringer, Arno;Bazin, Pierre-Louis;Steele, Christopher J.;Gauthier, Claudine J.
• 通讯作者: Gauthier, Claudine J.

Characterizing systemic physiological effects on the blood oxygen level dependent signal of resting-state fMRI in time-frequency space using wavelets.

• DOI: 10.1002/hbm.26533
• 发表时间: 2023-12-15
• 期刊: HUMAN BRAIN MAPPING
• 影响因子: 4.8
• 作者: Lee, Quimby N.;Chen, Jingyuan E.;Wheeler, Gregory J.;Fan, Audrey P.
• 通讯作者: Fan, Audrey P.

Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniques.

脑血管反应性测量的再现性：神经影像技术的系统评价。

• DOI: 10.1177/0271678x211056702
• 发表时间: 2022
• 期刊: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
• 作者: Zhao,MossY;Woodward,Amanda;Fan,AudreyP;Chen,KevinT;Yu,Yannan;Chen,DavidY;Moseley,MichaelE;Zaharchuk,Greg
• 通讯作者: Zaharchuk,Greg