Advanced MR Imaging of Perinatal White Matter Injury

围产期脑白质损伤的高级 MR 成像

基本信息

批准号：
8431807
负责人：
Ashok Panigrahy
金额：
$ 18.55万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-01 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8431807
关键词：
6 year old Age Attention Autistic Disorder Autopsy Axon Basal Ganglia Biological Markers Brain Brain region Cerebral Ischemia-Hypoxia Cerebral Palsy Cerebral cortex Cerebrum Child Childhood Clinical Management Clinical Research Cognition Cognition Disorders Cognitive Common Ventricle Data Databases Detection Development Diagnosis Diffuse Diffusion Diffusion Magnetic Resonance Imaging Early Intervention Enrollment Evaluation Free Radicals Gliosis Glutamates Goals Hypoplastic Left Heart Syndrome Hypoxia Imaging Techniques Impaired cognition Incidence Infant Injury Inositol Intelligence Knowledge Lead Learning Life Long-Term Survivors Longitudinal Studies Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Measurement Measures Mental disorders Metric Myelin N-acetylaspartate Nature Necrosis Neonatal Neurological outcome Neuronal Injury Neurons Oligodendroglia Osmolar Concentration Outcome Participant Pathogenesis Pathologic Patients Pediatric Neurology Perinatal Perinatal Brain Injury Periventricular Leukomalacia Physiology Population Premature Infant Problem behavior Protons Psychology Publishing Research Research Design Risk Risk Factors Secondary to Services Survivors Techniques Testing Thalamic structure Time Toddler Toxic effect Transposition of Great Vessels United States astrogliosis axonal degeneration base career clinical practice congenital heart disorder cytokine density fetal infection follow-up gray matter high risk imaging modality improved motor deficit neonate neurobehavioral neurocognitive test neurodevelopment neuroimaging neuronal cell body neuropathology neuropsychological oligodendrocyte precursor precursor cell premature skills statistics white matter white matter injury

项目摘要

Perinatal brain injury is a significant problem given the high incidence of prematurity in the United States, with an estimated increase of 28% over the past 20 years. It is now estimated that up to 40% of survivorsof perinatal brain injury are compromised neurologically, including motor deficits, learning and behavioral problems. Our overall hypothesis is that magnetic resonance spectroscopy (MRS) may be a biomarker of the diffuse component of perinatal white matter injury and that altered neonatal NAA and NAA/myo-inositol ratio will correlate with long term neurodevelopmental outcome and thalamo-cortical abnormalities as assessed with advanced MR techniques at 6 years of age. We will specifically focus on premature infants at term equivalent age and term infants with congenital heart disease (transposition of the great arteries and single ventricle physiology). Our specific aims are: Aim 1: Determine "normative levels" of absolute concentration of NAA and myo-inositol in neonatal cerebral white matter using a longitudinal study design by (1a) performing MRS in term infants with no risk factors for perinatal white matter injury; (1b) performing longitudinal neurodevelopmental assessment at 18 months, 36 months and 6 years of age; (1c) performing DTI and VM MR imaging at 6 yrs of age.Aim 2: To determine the levels of absolute concentration of NAA and myo-inositol in the cerebral white matter using a longitudinal study design by (2a) performing MRS in term equivalent premature infants (2b) performing longitudinal neurodevelopmental assessment at 18 months, 36 months and 6 years of age (2c) performing DTI and VM MR imaging at 6 yrs of age. Aim 3: To determine the levels of absolute concentration of NAA and myo-inositol in the cerebral white matter using a longitudinal study design by (3a) performing MRS in term infants with congenital heart disease (3b) performing longitudinal neurodevelopmental assessment at 18 months, 36 months and 6 years of age (3c) performing DTI and VM MR imaging at 6 yrs of age. As part of the career plan, the applicant will obtain skills in (1) advanced MR imaging techniques (2) clinical research outcome, advanced statistics and clinical management skills, and (3) neonatal neuropathology, pediatric neurology and pediatric neuro-psychology.

鉴于美国早产率很高，围产期脑损伤是一个重要问题，预计在过去 20 年中增长了 28%。目前估计高达 40% 的幸存者围产期脑损伤会损害神经系统，包括运动缺陷、学习和行为问题。我们的总体假设是，磁共振波谱（MRS）可能是以下疾病的生物标志物：围产期白质损伤的弥漫性成分，并改变了新生儿 NAA 和 NAA/肌醇比率将与长期神经发育结果和丘脑皮质异常相关 6 岁时使用先进的 MR 技术进行评估。我们将特别关注早产儿患有先天性心脏病（大动脉转位和动脉转位）的足月等效年龄和足月婴儿单心室生理学）。我们的具体目标是：目标 1：确定绝对值的“规范水平” 使用纵向研究设计测定新生儿脑白质中 NAA 和肌醇的浓度 (1a) 对没有围产期脑白质损伤危险因素的足月儿进行 MRS； (1b) 执行 18个月、36个月和6岁时的纵向神经发育评估； (1c) 执行 6 岁时的 DTI 和 VM MR 成像。目标 2：确定 NAA 的绝对浓度水平和肌醇在大脑白质中使用纵向研究设计，通过（2a）在足月等效早产儿 (2b) 在 18 岁时进行纵向神经发育评估个月、36 个月和 6 岁时 (2c) 在 6 岁时进行 DTI 和 VM MR 成像。目标 3：使用a测定脑白质中NAA和肌醇的绝对浓度水平纵向研究设计：(3a) 对患有先天性心脏病的足月儿进行 MRS (3b) 在 18 个月、36 个月和 6 岁时进行纵向神经发育评估 (3c) 6 岁时进行 DTI 和 VM MR 成像。作为职业计划的一部分，申请人将获得技能 (1) 先进的 MR 成像技术 (2) 临床研究成果、先进的统计数据和临床管理技能，以及（3）新生儿神经病理学、小儿神经病学和小儿神经心理学。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Magnetic resonance spectroscopy in pediatric neuroradiology: clinical and research applications.

儿科神经放射学中的磁共振波谱：临床和研究应用。

DOI：
发表时间：
2010-01
期刊：
影响因子：
2.3
作者：
Panigrahy, Ashok;Nelson Jr, Marvin D;Blüml, Stefan
通讯作者：
Blüml, Stefan

Altered glutamatergic metabolism associated with punctate white matter lesions in preterm infants.

与早产儿点状白质病变相关的谷氨酸代谢改变。

DOI：
发表时间：
2013
期刊：
影响因子：
3.7
作者：
Wisnowski, Jessica L;Blüml, Stefan;Paquette, Lisa;Zelinski, Elizabeth;Nelson Jr, Marvin D;Painter, Michael J;Damasio, Hanna;Gilles, Floyd;Panigrahy, Ashok
通讯作者：
Panigrahy, Ashok

Thalamic alterations in preterm neonates and their relation to ventral striatum disturbances revealed by a combined shape and pose analysis.

通过形状和姿势组合分析揭示早产儿丘脑的改变及其与腹侧纹状体紊乱的关系。

DOI：
发表时间：
2016-01
期刊：
影响因子：
3.1
作者：
Lao, Yi;Wang, Yalin;Shi, Jie;Ceschin, Rafael;Nelson, Marvin D;Panigrahy, Ashok;Leporé, Natasha
通讯作者：
Leporé, Natasha

Olfactory bulb and olfactory tract abnormalities in acrocallosal syndrome and Greig cephalopolysyndactyly syndrome.

肢端胼胝体综合征和格雷格头多指并指综合征中的嗅球和嗅道异常。

DOI：
发表时间：
2019
期刊：
影响因子：
2.3
作者：
Subramanian, Subramanian;Soundara Rajan, Deepa;Gaesser, Jenna;Wen;Panigrahy, Ashok
通讯作者：
Panigrahy, Ashok

Abnormal Ventricular Development in Preterm Neonates with Visually Normal MRIs.

MRI 视觉正常的早产儿心室发育异常。

DOI：
发表时间：
2015-11
期刊：
影响因子：
0
作者：
Shi, Jie;Wang, Yalin;Lao, Yi;Ceschin, Rafael;Mi, Liang;Nelson, Marvin D;Panigrahy, Ashok;Leporé, Natasha
通讯作者：
Leporé, Natasha