Modeling of Collateral Perfusion in the Ischemic Brain

缺血性脑部侧支灌注的建模

• 批准号: 8534303
• 负责人: DAVID SIGMUND LIEBESKIND
• 金额: $ 18.79万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-26 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8534303
• 关键词: Academic achievement; Achievement; Acute; Address; Angiography; Arteries; Behavior assessment; Blood - brain barrier anatomy; Blood Vessels; Blood flow; Brain; Brain Ischemia; Caring; Catheters; Cerebrovascular Circulation; Clinical; Clinical Research; Clinical Sciences; Cohort Studies; Communication; Communities; Computer software; Data; Development; Educational Curriculum; Effectiveness; Ensure; Environment; Etiology; Faculty; Fostering; Funding; Future; Generations; Genetic; Goals; Grant; Growth; Imaging technology; Individual; Infarction; Influentials; Institutes; Internet; Ischemic Stroke; Knowledge; Magnetic Resonance; Magnetic Resonance Imaging; Measures; Medical; Mentors; Mentorship; Methodology; Microcirculation; Mid-Career Clinical Scientist Award (K24); Modeling; Neurologic; Neurological outcome; Neurology; Neurosciences; Outcome; Outcome Measure; Outcomes Research; Perfusion; Public Health; Publications; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Technics; Research Training; Resources; Role; Scientist; Software Tools; Stroke; Structure; Techniques; Testing; Therapeutic; Tissues; Training; Training Programs; Translational Research; Variant; Veins; Venous; Work; X-Ray Computed Tomography; acute stroke; base; blood perfusion; career; career development; clinically relevant; hemodynamics; improved; innovation; lectures; meetings; model development; nervous system disorder; neuroimaging; novel; patient oriented research; pressure; prognostic; programs; prospective; responsible research conduct; skills; tool; treatment strategy; trend; web site

PROJECT SUMMARY/ABSTRACT Common neurological disorders pose an increasingly formidable public health burden that requires studies of underlying mechanisms and ample effort of patient-oriented research (POR) investigators. This midcareer application's long-term mentoring program goal is to train leading young translational scientists from diverse neurologic subspecialties in POR, redressing the mentoring gap in neurology POR that threatens future progress, and the long-term research project goal is to increase understanding of collateral perfusion in stroke. An innovative mentoring infrastructure for selected residents, clinical fellows and junior faculty is proposed with content mentors in neurologic subspecialties and an overall POR mentor. Mentoring aims include 1) establishing departmental mentoring infrastructure, one-on-one mentoring, trainee research, career development and website resources; 2) creating new courses on neurology clinical and translational research and scientific communications; and 3) continually enhancing faculty mentorship skills. The impact of this mentoring program at UCLA will be tracked with specific outcome measures to ensure achievement of trainee and overall program milestones. This K24 award will help achieve departmental long-term goals to enhance POR across neurologic subspecialties, establish formal neurology POR mentorship, stimulate independent research of trainees and foster an inspiring intellectual environment to increase the number of future neurology POR investigators. This integrated approach to neurology POR training also benefits from a focused research strategy to develop a model of collateral perfusion for content mentoring in stroke, a project that provides mentoring opportunities over a diverse spectrum of POR techniques. Novel neuroimaging and angiography approaches will be used to develop and validate a regional model of collateral perfusion using pressure differentials in arteries, tissue, and veins to predict tissue fate and neurological outcomes in acute ischemic stroke. This clinically relevant work on an important topic in stroke care will enhance understanding of collateral perfusion, including the distinct contributions of arterial and venous segments of the cerebral circulation. In addition to the advancement of scientific knowledge and provision of mentoring opportunities, a tangible resulting product will be a software tool to enhance prediction of tissue fate and neurological outcomes in acute stroke across diverse causes of brain ischemia.

项目概要/摘要 常见的神经系统疾病构成了日益沉重的公共卫生负担，需要对以下问题进行研究 潜在的机制和以患者为中心的研究（POR）研究者的大量努力。这个职业中期 应用程序的长期指导计划目标是培训来自不同领域的领先年轻转化科学家 POR 的神经学亚专业，弥补威胁未来的神经学 POR 的指导差距 进展，长期研究项目的目标是增加对中风侧支灌注的了解。 建议为选定的住院医师、临床研究员和初级教员建立创新的指导基础设施 神经学亚专业的内容导师和整体 POR 导师。指导目标包括 1) 建立部门指导基础设施、一对一指导、实习生研究、职业生涯 开发和网站资源； 2）开设神经病学临床和转化研究新课程 和科学传播； 3）不断提高教师指导技能。这的影响 加州大学洛杉矶分校的指导计划将通过具体的成果衡量标准进行跟踪，以确保学员取得成就 以及总体计划的里程碑。该 K24 奖项将有助于实现部门的长期目标，以提高 跨神经科亚专业的 POR，建立正式的神经科 POR 指导，激发独立性 学员的研究并营造一个鼓舞人心的智力环境，以增加未来神经病学的数量 POR 调查员。这种神经病学 POR 培训的综合方法也受益于重点研究 开发用于中风内容指导的侧支灌注模型的策略，该项目提供 针对各种 POR 技术的指导机会。新型神经影像学和血管造影 方法将用于开发和验证使用压力的侧枝灌注的区域模型 动脉、组织和静脉的差异可预测急性缺血的组织命运和神经系统结果 中风。这项关于中风护理重要主题的临床相关工作将增强对抵押品的理解 灌注，包括脑循环的动脉和静脉段的独特贡献。在 除了提高科学知识和提供指导机会外， 由此产生的产品将成为一种软件工具，可增强急性急性期组织命运和神经系统结果的预测 脑缺血的多种原因引起的中风。