CWRU- Cardiovascular Research Training Program

CWRU-心血管研究培训计划

• 批准号: 10225361
• 负责人: MUKESH Kumar JAIN
• 金额: $ 28.66万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10225361
• 关键词: Cardiovascular system; Research Training; Training Programs

Project Summary/Abstract The goal of this Cardiovascular Research Training Program (CRTP) is to provide outstanding training in basic cardiovascular research to promising predoctoral students and highly qualified MD or PhD postdoctoral fellows. The program includes 29 senior trainers and 8 junior trainers from 6 PhD programs and 4 clinical divisions at Case Western Reserve University. The recruited faculty are known for excellence in research, ample NIH funding, and robust research space. The Cardiovascular Research Institute (CVRI) serves as the integrating platform for all trainers on this grant. Training focuses on relating the basic approaches of molecular and cellular biology, physiology, biophysics, biomedical engineering, and imaging to mechanistic questions and problems pertinent to the cardiovascular system in health and disease, with particular emphasis on (a) Cardiovascular metabolism and inflammation, (b) Cardiac function, failure, and arrhythmia, (c) Vascular pathophysiology, and (d) Cardiovascular tissue engineering and imaging. The majority of student recruitment is through the Medical Scientist and Biomedical Sciences Training Programs, and includes a strong commitment to the recruitment of women and under-represented minorities. Predoctoral training is accomplished in PhD programs in Biomedical Engineering, Epidemiology & Biostatistics, Molecular Medicine, Pharmacology, Pathology, and Physiology & Biophysics. The basic coursework and guided training in research skills provided by these departmental programs is supplemented and enhanced by CRTP-specific components. These include completion of a required graduate course in Cardiovascular Physiology, an exciting Immersion Experience in Cardiovascular Healthcare, participation in a weekly seminar series, a monthly journal club, and an annual CVRI research retreat. A CRTP faculty committee that includes senior trainers and junior trainers, who are developing independent programs in cutting-edge areas of cardiovascular research, mentor each trainee. Postdoctoral trainees, including physicians from the Harrington Physician Scientist Pathway, are appointed via their recruitment to CRTP trainer labs and will also participate in the Cardiovascular Healthcare Immersion, CVRI seminars/retreats/journal club, and the mentoring process. In total, this application seeks 8 positions (4 predoctoral and 4 postdoctoral) per year.

项目摘要/摘要 该心血管研究培训计划（CRTP）的目标是提供基本的出色培训 对有前途的前学生和高素质的MD或博士博士博士学位研究员的心血管研究。 该计划包括来自6个博士学位课程的29名高级培训师和8位初级培训师，以及4个临床部门 案例西部储备大学。招募的教师以卓越的研究而闻名，足够的NIH 资金和强大的研究空间。心血管研究所（CVRI）作为整合 该赠款的所有培训师的平台。培训的重点是关联分子和细胞的基本方法 生物学，生理学，生物物理学，生物医学工程以及成像机械问题和问题 与健康和疾病的心血管系统有关，特别强调（a）心血管 代谢和炎症，（b）心脏功能，衰竭和心律不齐，（c）血管病理生理学和 （d）心血管组织工程和成像。大多数学生招聘是通过医疗 科学家和生物医学科学培训计划，包括对招募的坚定承诺 妇女和代表性不足的少数民族。专业培训是在生物医学的博士学位课程中完成的 工程，流行病学与生物统计学，分子医学，药理学，病理学和生理学 生物物理学。这些部门提供的基本课程和研究技能的指导培训 通过CRTP特异性组件补充和增强了程序。这些包括完成所需的 心血管生理学的研究生课程，心血管的令人兴奋的沉浸式体验 医疗保健，参加每周研讨会系列，每月期刊俱乐部和年度CVRI研究 撤退。一个CRTP教师委员会，包括高级培训师和初级培训师，他们正在开发 在心血管研究的尖端领域的独立计划，每个受训者的导师。博士后 包括哈灵顿医师科学家途径的医生在内的学员，由他们的 招募CRTP培训师实验室，还将参加CVRI的心血管医疗保健浸入 研讨会/务虚会/期刊俱乐部和指导过程。总共该应用程序寻求8个职位（4个 每年占主导地位和4个博士后）。

项目成果

Standardized microfluidic assessment of red blood cell-mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease.

• DOI: 10.1111/micc.12662
• 发表时间: 2021-03
• 期刊: Microcirculation (New York, N.Y. : 1994)
• 作者: Man Y;Kucukal E;An R;Bode A;Little JA;Gurkan UA
• 通讯作者: Gurkan UA

Emerging functional microfluidic assays for the study of thromboinflammation in sickle cell disease.

• DOI: 10.1097/moh.0000000000000731
• 发表时间: 2022-11-01
• 期刊: CURRENT OPINION IN HEMATOLOGY
• 影响因子: 3.2
• 作者: An, Ran;Gurkan, Umut A.
• 通讯作者: Gurkan, Umut A.

Fecal Microbiome Composition Does Not Predict Diet-Induced TMAO Production in Healthy Adults.

• DOI: 10.1161/jaha.121.021934
• 发表时间: 2021-11-02
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Ferrell M;Bazeley P;Wang Z;Levison BS;Li XS;Jia X;Krauss RM;Knight R;Lusis AJ;Garcia-Garcia JC;Hazen SL;Tang WHW
• 通讯作者: Tang WHW

Microfluidic electrical impedance assessment of red blood cell-mediated microvascular occlusion.

• DOI: 10.1039/d0lc01133a
• 发表时间: 2021-03-21
• 期刊: Lab on a chip
• 影响因子: 6.1
• 作者: Man Y;Maji D;An R;Ahuja SP;Little JA;Suster MA;Mohseni P;Gurkan UA
• 通讯作者: Gurkan UA

Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease.

• DOI: 10.1111/bjh.16671
• 发表时间: 2020-08
• 期刊: British journal of haematology
• 影响因子: 6.5
• 作者: Noomuna P;Risinger M;Zhou S;Seu K;Man Y;An R;Sheik DA;Wan J;Little JA;Gurkan UA;Turrini FM;Kalfa T;Low PS
• 通讯作者: Low PS