Core D - Energy Balance and Body Composition Core

核心 D - 能量平衡和身体成分核心

基本信息

批准号：
10225373
负责人：
Changcheng Zhou
金额：
$ 19.13万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10225373
关键词：
Acclimatization Adipose tissue Animals Area Blood Pressure Body Composition Body Water Body Weight Cardiovascular Diseases Cells Chronic Collaborations Communities Conscious Consultations Coupled Data Analyses Diabetes Mellitus Diet Eating Energy Metabolism Equipment Exercise Experimental Models Fatty acid glycerol esters Fees Food Energy Fostering Funding Genetic Genome Growth Health care facility Human Resources Indirect Calorimetry Individual Institution Intervention Kentucky Laboratories Longitudinal Studies Magnetic Resonance Imaging Malignant Neoplasms Measurement Metabolism Methods Modernization Mus Neurodegenerative Disorders Obese Mice Obesity Obesity Epidemic Obesity associated disease Phase Physical activity Pilot Projects Principal Investigator Proteins Recommendation Regulation Research Research Design Research Personnel Resources Running Services Standardization Structure Study models System Therapeutic Thinness Time Tissues Training United States National Institutes of Health Water consumption Weight animal care base cardiovascular risk factor data handling diet-induced obesity dietary energy balance experience feeding health disparity improved insight mid-career faculty obesity development operation outreach program programs time use

项目摘要

The Energy Balance and Body Composition Core (Core D) serves investigators across the institution to quantify energy balance and body composition in mice. Accurate quantification of these parameters is essential for studies focused on obesity, with wide-spread capabilities for metabolism-related studies. The core houses 24 LabMaster TSE® chambers that quantify food and water intake, physical activity and indirect calorimetry in mice, a common model for studies focused on the effect of diet or genetics on the development of obesity. The Core also houses an EchoMRI® to quantify lean and fat mass and total body water in conscious mice. Both systems allow for non-invasive longitudinal assessment of energy balance and body composition. Competent core staff maintain and oversee the use of the LabMaster TSE® system and train personnel in use of the EchoMRI®. Core Directors assist in study design and data handling and analysis. Over 50 Principal Investigators use the LabMaster TSE® system annually for studies on >700 mice/year, while the EchoMRI® is used by more than 25 laboratories annually. These systems are not duplicated at the institution or within the Commonwealth, and are vital to our ability to reduce the epidemic of obesity in Kentucky. In Phase III of the program, we will broaden our focus to include obesity as a risk factor for cardiovascular diseases, diabetes, cancer and neurodegenerative diseases. This will increase use of the system to support an anticipated larger user base with targeted growth within these areas across the institution. We will also purchase a new system, from institutional support, that will markedly expand capabilities of this core in quantifying energy metabolism in mice. Also, during Phase III of the program the core for this system, including all equipment, will be relocated to a modern animal care facility within a new research building that is dedicated to the study of these health disparities. We anticipate that this core will transition to self-sustaining capacity over the course of Phase III support of the COCVD.

能量平衡和身体成分核心（核心D）为整个研究所的调查人员提供服务量化小鼠的能量平衡和身体组成。对肥胖症的研究至关重要，具有与代谢相关的研究的广泛能力核心房屋24个LabmasterTSE®腔室，可量化食物和水的摄入量，体育锻炼和间接小鼠的量热法，这是一种集中于饮食或遗传学对发展的影响的常见研究模型核心。有意识的小鼠。组成。使用Echomri®的人员。超过50名主要研究人员每年使用LabmasterTSE®系统进行> 700只鼠标的研究，而 Echomri®每年都有25个以上的实验室使用。裁定或在联邦内部，至少有生命肯塔基州。心血管疾病，糖尿病，癌症和神经退行性疾病。支持预期的较大的用户固定器基础基础基础，并具有针对性的增长机构。核心在量化小鼠的能量代谢方面的能力。该系统的核心（包括所有设备）将被搬迁到新的动物护理设施中致力于研究这些健康差异的研究大楼。在COCVD的III阶段支持过程中，过渡到自我维持的能力。