Fecobionics device for mapping colonic and anorectal neuromuscular function

用于绘制结肠和肛门直肠神经肌肉功能的 Fecobionics 装置

基本信息

批准号：
10227270
负责人：
Hans Gregersen
金额：
$ 15.25万
依托单位：
CALIFORNIA MEDICAL INNOVATIONS INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-22 至 2020-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10227270
关键词：
Address Adverse effects Aging Agreement Anal canal Anatomy Animals Behavior Benchmarking Biological Markers Bionics Biosensor Canis familiaris Characteristics Colon Colorectal Complex Conflict (Psychology)Defecation Defecography Denervation Development Devices Diagnostic Diet Digestive System Disorders Disease Documentation Enteral Enteric Nervous System Feces Functional Imaging Functional disorder Gastrointestinal Diseases Goals Health Health Care Costs Histologic Intervention Investigation Knowledge Lower Gastrointestinal Tract Magnetic Resonance Imaging Magnetism Manometry Maps Measurement Measures Methods Mission Modeling Mucous Membrane Nerve Nervous System control Neuromuscular conditions Organ Pelvis Performance Peripheral Nerves Peripheral Nervous System Physiological Physiology Process Radiation Rectum Reflex action Research Resolution Risk Sacral nerve Safety Shapes Sterility Technology Test Result Testing Therapeutic Time TimeLine Tissues Treatment outcome Ultrasonography Vision Wireless Technology Work associated symptom biomaterial compatibility body system cost cytotoxicity design gastrointestinal gastrointestinal function innovation insight mathematical model models and simulation neuromuscular neuromuscular function neuromuscular system neuroregulation new technology novel novel diagnostics novel strategies pressure safety study simulation symptom treatment three dimensional structure tool transmission process validation studies

项目摘要

The colon and anorectum have complex composition. Methods to study neuromuscular interactions and activity in health and gastrointestinal (GI) disease have been limited due to difficult access and lack of appropriate technologies. Many aspects of colonic mechanosensory physiology are still not well understood including the influence of enteric circuits and reflexes, and extrinsic nerve function in the various segments of the colon. The need for new technology and a better understanding of the neuromuscular function is substantial. A significant problem is a lack of physiologically-relevant and practical test for identifying the underlying mechanism(s). Hence, the overall objective is to validate a fully integrative dynamic tool that mimics feces transport in the lower GI tract. Accordingly, the following tasks are proposed: 1) Optimization of a wireless development of Fecobionics device and System for neuromuscular function studies of the colon. Milestone: Wireless device that can record during transport through colon and anorectum; 2) Conduct safety and performance studies in dogs (including IDE approval): Milestone: Studies that demonstrates safety and performance of the device under different neuromuscular conditions; and 3) Develop a validated mathematical model of the lower GI tract. Milestone: Geometric and functional mathematical model for colonic transport and defecation. The proposed technology (Fecobionics) is a simulated electronic feces that has the consistency and shape of normal stool. The measured variables in Fecobionics include multiple pressures, shape changes, velocity and orientation. Hence, it will be feasible to map and describe objectively (without disturbing the colonic transport and defecation processes) the transport characteristics and neuromuscular signatures during colonic transport and initial entry from the rectum into the relaxing anal canal. This unique device will provide new neuromuscular signatures of the lower GI tract under normal circumstances, and during intervention with enteric and peripheral nerve activity to enhance our understanding of physiological and pathophysiological mechanisms involved in the lower GI tract neuromuscular function. In line with SPARC mission, we intend to provide a new technology for lower GI testing, simulating normal stool transport and defecation with a bionics device. This technology will replace several current tests, because it provides an integrated frame work for assessing function and obviates the need for multiple tests of function. The central premise is that a novel and unique Fecobionics device that mimics natural lower GI transport will provide new mechanistic insights regarding colonic and anorectal physiology when compared to standard tests and facilitate development of new diagnostics for lower GI disorders. The significance is to address the major gaps in knowledge by developing a safe, low cost, less invasive, low risk, radiation-free device, and test its ability to provide new understanding of colonic neuromuscular and defecation function. This may later facilitate development of diagnostic and therapeutic tools that will reduce healthcare costs.

结肠和肛门具有复杂的成分。研究神经肌肉相互作用和活性的方法在健康和胃肠道（GI）疾病中，由于难以进入和缺乏适当的措施而受到限制技术。结肠机械感觉生理学的许多方面仍然不太了解肠电路和反射的影响，以及在结肠的各个段中的外在神经功能。这对新技术的需求和对神经肌肉功能的更好理解是很大的。重要的问题是缺乏与生理相关的实用检验来识别潜在的机制。因此，总体目标是验证一个完全集成的动态工具，以模仿粪便中的粪便传输胃肠道。因此，提出了以下任务：1）优化的无线开发结肠神经肌肉功能研究的繁殖力和系统。里程碑：无线设备可以记录在结肠和肛门的运输过程中； 2）进行安全性和绩效研究在狗（包括IDE批准）中：里程碑：证明设备安全性和性能的研究在不同的神经肌肉条件下； 3）开发较低GI的经过验证的数学模型道。里程碑：结肠运输和排便的几何和功能数学模型。这拟议的技术（Fecobionics）是一种模拟的电子粪便，具有正常的一致性和形状凳子。粪便学中测量的变量包括多种压力，形状变化，速度和方向。因此，可以客观地绘制和描述（而不打扰结肠运输，将是可行的和排便过程）结肠运输过程中的传输特性和神经肌肉特征并从直肠进入放松肛管。这种独特的设备将提供新的神经肌肉在正常情况下以及在与肠和外围的干预期间，下胃肠道的签名神经活动以增强我们对涉及的生理和病理生理机制的理解较低的胃肠道神经肌肉功能。根据SPARC任务，我们打算为降低胃肠道测试，使用生物设备模拟正常的粪便传输和排便。这项技术将更换当前的几个测试，因为它提供了用于评估功能的集成框架工作并避免需要多次功能测试。中心前提是一种新颖而独特的繁殖装置模拟自然gi运输将提供有关结肠和厌食的新机械见解与标准测试相比，生理学并促进了较低GI的新诊断疾病。意义是通过开发安全，低成本，更少来解决知识的主要差距侵入性，低风险，无辐射设备，并测试其对结肠的新理解的能力神经肌肉和排便功能。后来可能有助于开发诊断和治疗工具这将降低医疗保健成本。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Novel Bionics Assessment of Anorectal Mechanosensory Physiology.

DOI：
10.3390/bioengineering7040146
发表时间：
2020-11-14
期刊：
Bioengineering (Basel, Switzerland)
影响因子：
0
作者：
Gregersen H
通讯作者：
Gregersen H

Computational analysis of mechanical stress in colonic diverticulosis.

结肠憩室病机械应力的计算分析。

DOI：
10.1038/s41598-020-63049-w
发表时间：
2020
期刊：
Scientific reports
影响因子：
4.6
作者：
Patel,Bhavesh;Guo,Xiaomei;Noblet,Jillian;Chambers,Sean;Gregersen,Hans;Kassab,GhassanS
通讯作者：
Kassab,GhassanS

Mechanophysiological analysis of anorectal function using simulated feces in human subjects.

使用模拟人类粪便对肛门直肠功能进行机械生理学分析

DOI：
10.1016/j.jare.2020.07.002
发表时间：
2021-03
期刊：
Journal of advanced research
影响因子：
10.7
作者：
Sun D;Liao D;Chen SC;Wong C;Wah Leung W;Futaba K;Mak T;Ng S;Gregersen H
通讯作者：
Gregersen H

Simulated Colonic Feces Reveals Novel Contraction Patterns.

DOI：
10.1053/j.gastro.2020.09.055
发表时间：
2021-02
期刊：
Gastroenterology
影响因子：
29.4
作者：
通讯作者：

New developments in defecatory studies based on biomechatronics.

DOI：
10.1016/j.jare.2021.05.005
发表时间：
2022-01
期刊：
Journal of advanced research
影响因子：
10.7
作者：
Gregersen H;Sun D;Chen SC;Leung WW;Wong C;Mak T;Ng S;Futaba K;Lo KM;Kassab GS
通讯作者：
Kassab GS