Keeping it LITE: Exploring HIV Risk in Vulnerable Youth with Limited Interaction

保持精简：通过有限的互动探索弱势青少年的艾滋病毒风险

• 批准号: 10223118
• 负责人: Audrey French
• 金额: $ 58.16万
• 依托单位: HEKTOEN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-22 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10223118
• 关键词: AIDS prevention; Address; Adherence; Adolescent and Young Adult; Advertisements; Age; Area; Attitude; Behavior; Biological; Caring; Characteristics; Chicago; Cognitive; Color; Communities; Continuity of Patient Care; Data; Development; Diagnostic; Enrollment; Epidemic; Epidemiology; HIV; HIV Infections; HIV Seropositivity; HIV risk; Human immunodeficiency virus test; Individual; Infection; Intervention; Longitudinal cohort; Longitudinal cohort study; Methodology; Monitor; Newly Diagnosed; Pathway Analysis; Phase; Phylogenetic Analysis; Population; Prevention; Prevention strategy; Provider; Public Health; Risk; Services; Social Change; Social Network; Structure; Subgroup; Technology; Testing; Time; United States; Viral; Youth; behavior influence; burden of illness; cohort; cost effective; design; enhancing factor; feasibility testing; high risk; infection rate; infection risk; innovation; intervention effect; men who have sex with men; novel; novel strategies; pre-exposure prophylaxis; preventive intervention; psychologic; recruit; response; social media; sociodemographics; tool development; transgender women; transgender women who have sex with men; transmission process; trend; uptake; virtual; virtual intervention; young man; young men who have sex with men

PROJECT SUMMARY/ABSTRACT In response to RFA-AI-16-031, we propose “Keeping it LITE: Exploring HIV Risk in Vulnerable Youth with Limited Interaction,” which will use electronic recruitment to engage young MSM and TGW in an innovative cohort designed to monitor HIV risk and prevention behaviors and explore the socioecological factors that influence behavior and attitudes with minimal engagement. This low-interaction strategy will allow us to describe ongoing infection trends across the Chicago area and characterize individual and community level factors that enhance HIV risk, while minimizing the potential intervention effects of study participation in and of itself. Further, given the rapidly advancing state of HIV prevention technologies, we will use our large, longitudinal cohort of HIV-uninfected youth to monitor PrEP access, uptake and adherence across time. More intensive study of those who acquire HIV while enrolled in the cohort, as well as those “prevalent positives” at baseline, using innovative social network and phylodynamic analysis, will identify clusters of ongoing active transmission and test the feasibility of novel approaches to target biomedical prevention to those in the highest risk subgroups. As the longitudinal data accumulate, we will be well-poised to design and pilot test virtual strategies for optimal HIV prevention for young MSM and TGW. Our proposed methodologies assure the maximum likelihood of leading to meaningful advances in HIV prevention including the development of tools and strategies that are easily implemented and scalable for export to other communities suffering from similar epidemics of HIV infection. We propose the following specific aims: Aim 1: To enroll and retain a large cohort of 13-34 year-old MSM and TGW (1000/year over 3 year) at high risk of HIV acquisition using tested, novel and cost-effective enrollment strategies through social media and targeted electronic advertisement. Aim 1a: To capture at least 230 HIV seroconversions occurring over the course of the study and 300 previously undiagnosed HIV-infected youth. Aim 1b: To explore behaviors, venues, sociodemographic characteristics and socioecological influences that predict HIV acquisition. Aim 2 (UH3 Stage): To characterize real-world PrEP use among young MSM and TGW enrolled and retained in a longitudinal cohort and explore the individual, provider and community-level predictors of PrEP uptake, PrEP adherence and PrEP discontinuation. Aim 3 (UH3 Stage): To use social network and phylodynamic analysis to identify characteristics of ongoing transmission networks of HIV seroconverters among young MSM and TGW enrolled in the cohort. Aim 3a: To provide data for optimal design and targeting of enhanced partner services and novel biomedical prevention strategies. Aim 4 (UH3 Stage): To describe the HIV care continuum among newly diagnosed young MSM/TGW Aim 4a: Identify individual, network, community and structural predictors of eventual viral suppression.

项目摘要/摘要 为了回应RFA-AI-16-031 有限的互动，”将使用电子招聘来吸引年轻的MSM和TGW参与创新 旨在监测艾滋病毒风险和预防行为的队列，并探索社会生态因素 影响行为，并以最小的参与度参加。这种低相互作用的策略将使我们能够 描述整个芝加哥地区正在进行的感染趋势，并描述个人和社区层面 增强艾滋病毒风险的因素，同时最大程度地减少研究参与的潜在干预效果 本身。此外，鉴于艾滋病毒预防技术的迅速发展，我们将使用我们的大型， 纵向艾滋病毒未感染的年轻人纵向监测时间的预科，摄取和遵守时间。更多的 对那些在参加队列时获得艾滋病毒的人以及那些在 基线，使用创新的社交网络和系统动力学分析，将确定正在进行的活动群体 传输和测试新方法靶向生物医学预防的可行性 风险亚组。随着纵向数据的积累，我们将被很好地设计和试点测试虚拟 针对年轻MSM和TGW的最佳HIV预防策略。我们提出的方法确保 导致艾滋病毒预防的有意义进步的最大可能性，包括开发工具 以及容易实施和可扩展的策略，以出口到其他具有类似的社区 HIV感染的流行病。我们提出以下特定目标：目标1：注册和保留大型队列 使用经测试的新颖的新型MSM和TGW（3年以上1000/年）的高风险 以及通过社交媒体和针对性电子广告的具有成本效益的注册策略。 AIM 1A： 在研究过程中捕获至少230种HIV血清转化，以前有300个 未经诊断的HIV感染的青年。目标1B：探索行为，场地，社会人口统计学特征和 社会生态生态影响预测艾滋病毒的收购。 AIM 2（UH3阶段）：表征现实世界的准备 在年轻的MSM和TGW中使用并保留在纵向队列中，并探索个人， 提供者和社区级别的预测指标的预测因素，预备依从性和中断。目标3 （UH3阶段）：使用社交网络和系统动力学分析来确定正在进行的特征 年轻的MSM和TGW中的HIV血清控制器的传输网络参与了队列。目标3a：to 提供最佳设计和靶向增强合作伙伴服务和新型生物医学预防的数据 AIM 4（UH3阶段）：描述新诊断的年轻MSM/TGW中的HIV护理连续体 AIM 4A：确定最终病毒抑制的个人，网络，社区和结构预测指标。

项目成果

Limited Interaction Targeted Epidemiology of HIV in Sexual and Gender Minority American Adolescents and Adults: Feasibility of the Keeping it LITE Study.

• DOI: 10.2196/30761
• 发表时间: 2021-11-26
• 期刊: JMIR formative research
• 影响因子: 2.2
• 作者: Gleason N;Serrano PA;Muñoz A;French A;Hosek S
• 通讯作者: Hosek S

Access to healthcare among sexual and gender minority youth at risk for HIV: barriers and experiences of discrimination.

面临艾滋病毒风险的性少数和性别少数青年获得医疗保健的机会：歧视的障碍和经历。

• DOI: 10.1080/09540121.2023.2209303
• 发表时间: 2023
• 期刊: AIDS care
• 影响因子: 1.7
• 作者: Gleason,Neil;Serrano,PedroA;Muñoz,Alejandro;Hosek,SybilG;French,AudreyL
• 通讯作者: French,AudreyL

Experiences of Online Racialized Sexual Discrimination among Sexual and Gender Minorities in the United States: Online Survey Data from Keeping It LITE.

美国性和性别少数群体在线种族化性别歧视的经历：来自 Keeping It LITE 的在线调查数据。

• DOI: 10.1080/00224499.2022.2103633
• 发表时间: 2023
• 期刊: Journal of sex research
• 影响因子: 3.6
• 作者: Gleason,Neil;Serrano,PedroA;Muñoz,Alejandro;French,AudreyL;Hosek,SybilG
• 通讯作者: Hosek,SybilG

Monkeypox-Induced Secondary Traumatic Stress: An Exploratory Analysis of Young Sexual and Gender Minority Adults Living in Illinois.

猴痘引起的继发性创伤应激：对生活在伊利诺伊州的年轻性和性别少数成年人的探索性分析。

• DOI: 10.1016/j.ejtd.2023.100349
• 发表时间: 2023
• 期刊: European journal of trauma & dissociation = Revue europeenne du trauma et de la dissociation
• 作者: Curtis,MichaelG;Davoudpour,Shahin;Felt,Dylan;French,AudreyL;Hosek,SybilG;Phillips,Gregory;Serrano,PedroA
• 通讯作者: Serrano,PedroA

Effect of Truvada lawsuit advertising on preexposure prophylaxis attitudes and decisions among sexual and gender minority youth and young adults at risk for HIV.

• DOI: 10.1097/qad.0000000000002728
• 发表时间: 2021-01-01
• 期刊: AIDS (London, England)
• 作者: Serrano PA;Daubert E;Munoz A;Hosek SG;French AL
• 通讯作者: French AL