Administrative Core

行政核心

• 批准号: 10220699
• 负责人: David H. O'Connor
• 金额: $ 27.5万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220699
• 关键词: Administrator; Americas; Animals; Arbitration; Biological; Charge; Collaborations; Communication; Communication Tools; Communities; Complex; Dangerousness; Development; Disputes; Doctor of Philosophy; Ensure; Equipment and supply inventories; Experimental Designs; Fetus; Functional disorder; Goals; Health Personnel; Human Resources; Infection; Institution; International; Intranet; Lead; Leadership; Natural Immunity; Participant; Policies; Pregnancy; Pregnant Women; Progress Reports; Protocols documentation; Reporting; Research; Research Personnel; Risk; Sampling; Scientist; Shipping; Students; System; Time; Training; United States National Institutes of Health; Vaccination; Vertebrates; Viremia; Work; ZIKA; Zika Virus; conflict resolution; congenital zika syndrome; data sharing; experience; meetings; member; neonate; programs; tool

Admin Core - Project Summary/Abstract The rapid and explosive spread of Zika virus has lead to the recognition that infection during pregnancy can lead to congenital Zika syndrome. The key hypothesis of this Program Project is that prolonged maternal viremia during pregnancy predicts the risk of congenital Zika syndrome. We will explore this hypothesis through three integrated projects. The Administrative (Admin) Core is charged with coordi- nating activities of the entire Program Project to ensure timely and efficient completion of the overall scientific goals. The activities of the Admin Core are broadly divided into five Specific Aims: Specific Aim 1. Coordinating communications between all participants. Specific Aim 2. Ensuring and maintaining regulatory compliance. Specific Aim 3. Managing program finances and overseeing subawards. Specific Aim 4. Enforcing policies pertaining to scientific rigor, transparency, data sharing, and con- flict resolution. Specific Aim 5. Promoting professional development of students and junior scientists participating in this Program Project. ZIKV is dangerous to pregnant women and their fetuses/neonates throughout the Americas. This risk will persist for at least several years, even if it is eventually curtailed by natural immunity and widespread vaccination. The Admin Core will coordinate all the Projects to ensure completion of all the scientific goals, providing important new tools for pregnant women and their healthcare providers to assess, and potentially reduce, the risk of congenital Zika syndrome.

管理员核心 - 项目摘要/摘要 寨卡病毒的快速和爆炸性传播导致人们的认识是感染期间感染 可以导致先天寨卡综合症。该计划项目的关键假设是延长 怀孕期间的孕产妇病毒血症预测先天性寨卡综合症的风险。我们将探索这个 通过三个集成项目的假设。行政（管理）核心收取协调 整个计划项目的纳特活动，以确保及时有效地完成整体 科学目标。管理员核心的活动大致分为五个具体目标： 具体目标1。协调所有参与者之间的通信。 具体目的2。确保和维持法规合规性。 特定目标3。管理计划财务和监督子宣告。 特定目的4。执行与科学严格，透明度，数据共享和概念有关的政策 FLICT解决方案。 具体目标5。促进学生和初级科学家的专业发展 这个程序项目。 ZIKV对整个美洲的孕妇及其胎儿/新生儿危险。这个风险 即使最终被自然的免疫力限制并广泛限制，将至少持续数年 疫苗接种。管理员核心将协调所有项目，以确保完成所有科学 目标，为孕妇及其医疗保健提供者提供重要的新工具，以评估和 有可能降低先天性寨卡综合症的风险。