PFAS Exposure and Health Effects in El Paso County, Colorado

科罗拉多州埃尔帕索县的 PFAS 暴露和健康影响

• 批准号: 10220758
• 负责人: JOHN L. ADGATE
• 金额: $ 100万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10220758
• 关键词: PFAS; Exposure; Health; Effects; El; PFAS; Exposure; Health; Effects; El

Project Summary/Abstract The overall goal of this research is to quantify the cross-sectional associations between measured and modeled perfluoroalkyl and polyfluoroalkyl substances (PFAS) in highly exposed adults and children and selected health outcomes, including lipids, kidney function, liver function, thyroid hormones and sex hormones, glucose and insulin parameters, markers of immune function, and neurobehavioral outcomes in children. We will enroll 1,000 adults and 400 children from a community in El Paso County, Colorado who experienced high levels of PFAS contamination of their municipal drinking water and private wells resulting from the use of aqueous film-forming foams (AFFF) for firefighting activities at a nearly US Air Force Base. Exposure to PFAS will be assessed via measured serum concentrations and through a detailed model to reconstruct historical PFAS concentrations in groundwater and drinking water in El Paso County. Combining this information with individual residential histories, we will be able to estimate cumulative lifetime exposure to AFFF-related PFAS in El Paso County for each study participant. Our research team is well qualified to achieve this goal due to our complementary expertise in exposure science (Adgate), environmental epidemiology (Starling), PFAS chemistry and drinking water exposure (Higgins, Vestergren), groundwater modeling (Singha, McCray), neurobehavioral testing (Wilkening), cancer epidemiology (Cockburn), statistical methods for the analysis of observational data (Glueck), and community outreach and education (Richardson, Celico). We have conducted a pilot study in El Paso County that demonstrates the feasibility of recruiting participants to complete study procedures similar to those in the ATSDR protocol. The preliminary results of our pilot study show: (1) a unique AFFF-related exposure profile with median concentrations of perfluorohexane sulfonate (PFHxS) more than ten times the median of the general US population, and (2) prominent differences in AFFF-related PFAS exposure by geographic area with an apparent north-south gradient in serum concentrations within El Paso County. In addition to the common core protocol, we propose two investigator-initiated aims: (1) a highly innovative examination of the association between PFAS and biomarkers linked to testicular and thyroid cancer risk (both previously identified in human and animal studies as potentially related to PFAS exposure), and (2) the application of novel statistical methods to estimate the combined effect of exposure to the complex mixture of PFAS found in AFFF-contaminated drinking water, and to separate the effects of individual PFAS from the correlated mixture. This research fills an important knowledge gap because populations in numerous US states have been exposed to AFFF-derived PFAS via contaminated drinking water. The completion of these aims will provide essential information for communities, researchers, and policymakers seeking to understand the health risks associated with this emerging PFAS exposure profile.

项目摘要/摘要 这项研究的总体目标是量化测量和 高度暴露的成年人和儿童以及 选定的健康结果，包括脂质，肾功能，肝功能，甲状腺激素和性激素， 儿童的葡萄糖和胰岛素参数，免疫功能的标志物以及神经行为结局。我们 将在科罗拉多州埃尔帕索县的一个社区中注册1000名成人和400名儿童 其市政饮用水和私人井的PFA污染水平是由于使用 在几乎美国空军基地，用于消防活动的水性膜形成泡沫（AFFF）。暴露于PFA 将通过测量的血清浓度和详细模型来评估以重建历史 El Paso县地下水和饮用水中的PFA浓度。将这些信息与 个别的住宅历史，我们将能够估计与AFFF相关的PFA的累积寿命暴露 每个研究参与者在埃尔帕索县（El Paso County）。由于我们的研究团队，我们的研究团队有资格实现这一目标 曝光科学的补充专业知识（ADGATE），环境流行病学（Starling），PFAS 化学和饮用水暴露（Higgins，Vestergren），地下水建模（Singha，McCray）， 神经行为测试（Wilkening），癌症流行病学（Cockburn），用于分析的统计方法 观察数据（Glueck）以及社区外展和教育（Richardson，Celico）。我们进行了 埃尔帕索县的一项试点研究，证明了招募参与者完成研究的可行性 类似于ATSDR协议中的程序。我们的试点研究的初步结果显示：（1）独特 与AFFF相关的暴露概况，中位浓度的全氟己烷磺酸盐（PFHXS）多于 美国普通人群的中位数和（2）与AFFF相关的PFA的显着差异 地理区域暴露于El Paso内血清浓度的明显南北梯度 县。除了公共核心方案外，我们还提出了两个研究者引发的目的：（1）高度 对与睾丸和甲状腺相关的PFA和生物标志物之间关联的创新检查 癌症风险（以前在人类和动物研究中鉴定为可能与PFAS暴露有关）， （2）应用新型统计方法来估计暴露于复合物的综合作用 在AFFF污染的饮用水中发现的PFA的混合物，并分离单个PFA的影响 从相关的混合物中。这项研究填补了重要的知识差距，因为许多人口 美国各州通过受污染的饮用水接触了AFFF的PFA。完成 这些目标将为寻求的社区，研究人员和政策制定者提供重要信息 了解与此新兴PFA暴露概况相关的健康风险。