Evaluating the Feasibility of Combined Aerobic and Resistance Exercise Training and Impact on Energy Balance Regulation in Breast Cancer Survivors

评估有氧运动和抗阻运动相结合的可行性及其对乳腺癌幸存者能量平衡调节的影响

• 批准号: 10217034
• 负责人: Sarah Anne Purcell
• 金额: $ 3.51万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10217034
• 关键词: Address; Adherence; Adoption; Adverse event; Aerobic; Aerobic Exercise; Affect; Age; American; Appetite Regulation; Authorship; Automobile Driving; Behavioral; Biometry; Body Composition; Body Weight; Breast Cancer Treatment; Breast Cancer survivor; Cancer Patient; Cancer Survivor; Clinical; Colorado; Communication; Control Groups; Data; Desire for food; Development; Dietary Intervention; Dietary intake; Early Diagnosis; Early treatment; Educational Intervention; Energy Intake; Energy Metabolism; Enrollment; Exercise; Fatigue; Fatty acid glycerol esters; Feedback; Financial compensation; Food; Foundations; Funding; Future; Goals; Guidelines; Health; Human; Hunger; Individual; Intervention; Intervention Trial; Knowledge; Laboratories; Lead; Life Style; Light; Malignant Neoplasms; Mass in breast; Mentors; Metabolism; Newly Diagnosed; Nutritional; Nutritional status; Obesity; Observational Study; Oncology; Outcome; Pain; Peptide YY; Physical Function; Physical activity; Physiological; Population; Premenopause; Public Health; Publications; Quality of life; Reaction; Recommendation; Regulation; Research; Research Project Grants; Rest; Risk; Satiation; Structure; Training; Training Programs; Translating; Universities; Weight; Woman; acceptability and feasibility; active method; base; cancer diagnosis; cancer recurrence; cancer therapy; career; career development; cohort; comorbidity; craving; design; dietary; effective intervention; energy balance; exercise intervention; exercise program; exercise training; ghrelin; hedonic; improved; indexing; malignant breast neoplasm; mode of exercise; obesity risk; programs; prospective; resistance exercise; response; sedentary; side effect; skills; strength training; therapy design; tool; total energy expenditure; treatment effect

PROJECT SUMMARY/ABSTRACT The applicant, Dr. Sarah Purcell, received graduate training in energy metabolism and body composition as it pertains to nutritional status in individuals with newly-diagnosed cancer. Dr. Purcell's long-term goal is to develop an independent research program that investigates energy balance as it relates to both nutrition and exercise interventions in clinical populations, including cancer and obesity. Examining regulators of energy balance such as appetite and physical activity will facilitate the development of more effective strategies to mitigate fat mass gain, maintain physical function, improve quality of life and ultimately reduce the public health burden of obesity. To help Dr. Purcell meet this goal, she has initiated postdoctoral research to investigate in how components of energy balance such as appetite, energy intake, and non-exercise activity are affected by structured exercise. Dr. Purcell and her mentoring team have developed a comprehensive training plan that will build upon her expertise in nutritional oncology while expanding her knowledge of energy balance in the context of exercise interventions, obesity, and oncology. Dr. Purcell’s primary training objectives include: 1) Improve theoretical knowledge of energy intake regulation, exercise, metabolism, and biostatistics, 2) Develop new research skills, 3) Lead a human intervention trial, 4) Enhance her professional development and network, and 5) Improve communication skills, publication record, and grantsmanship. To achieve these goals, Dr. Purcell’s proposed research project will 1) Examine the feasibility and acceptability of combining aerobic exercise training with an ongoing resistance exercise training program compared to resistance training alone, and 2) Elucidate potential alterations in appetite, energy intake, energy expenditure, and non-exercise physical activity during twelve weeks of combined aerobic/resistance exercise compared to a sedentary control condition among stage I-III breast cancer survivors. These activities will lead to several first-author publications and provide preliminary data to support continued mentored career development funding (i.e. K01). Data arising from this project will also inform the rationale and design of continued research aimed at understanding whole-body mechanisms of energy balance regulation in response to exercise training. Dr. Purcell will also have several opportunities for co-authorship within her sponsor’s and co-sponsor’s laboratories and other collaborators at the University of Colorado. Collectively, these activities will provide an unprecedented opportunity to develop Dr. Purcell’s research knowledge and skills, while providing a foundation for a successful independent research career.

项目摘要/摘要 申请人莎拉·珀塞尔（Sarah Purcell）博士接受了能量代谢和身体成分的研究生培训 与新诊断的癌症患者的营养状况有关。珀塞尔博士的长期目标是 制定一个独立的研究计划，该计划调查与营养和营养有关的能源平衡 考试能量调节器 诸如食欲和体育锻炼之类的平衡将有助于制定更有效的策略 减轻脂肪质量增加，维持身体机能，改善生活质量并最终降低公共卫生 肥胖负担。为了帮助Purcell博士实现这一目标，她启动了博士后研究，以调查 能量平衡的组成部分，例如食欲，能量摄入和非运动活动如何受到 结构化练习。 Purcell博士和她的心理团队制定了一项全面的培训计划 将基于她在营养肿瘤学方面的专业知识，同时扩大她对能量平衡的了解 运动干预，肥胖和肿瘤学的背景。珀塞尔博士的主要培训目标包括：1） 提高对能量摄入调节，运动，代谢和生物统计学的理论知识，2）发展 新研究技能，3）领导人类干预试验，4）增强她的专业发展和网络， 5）提高沟通技巧，出版记录和赠款技巧。为了实现这些目标，博士 Purcell提议的研究项目将1）检查结合有氧搜索的可行性和可接受性 与仅阻力训练相比，通过持续的抵抗运动训练计划进行运动训练 2）阐明食欲，能量摄入量，能量消耗和非运动身体的潜在改变 与久坐的控制相比 I-III期乳腺癌幸存者的状况。这些活动将导致几个第一职业的出版物 并提供初步数据以支持继续修补职业发展资金（即K01）。数据 该项目的产生还将为旨在理解的持续研究的基本原理和设计提供信息。 响应运动训练的能量平衡调节的全身机制。珀塞尔博士也将 在她的赞助商和共同赞助者的实验室和其他合着者和其他合着者中有几个机会 科罗拉多大学的合作者。总的来说，这些活动将提供前所未有的 开发Purcell博士的研究知识和技能的机会，同时为 成功的独立研究职业。