Predicting Autism through Behavioral and Biomarkers of Attention in Infants

通过婴儿注意力的行为和生物标志物预测自闭症

• 批准号: 8575340
• 负责人: Bridgette Lynne Kelleher
• 金额: $ 2.64万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-11-15 至 2014-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8575340
• 关键词: Affect; Age; Age-Months; Area; Attention; Autistic Disorder; Behavior; Behavioral; Biological Markers; Child; Cognitive; Communities; Cross-Sectional Studies; Deceleration; Development; Diagnosis; Diagnostic; Disease; Early Diagnosis; Early Intervention; Early identification; Early treatment; Employee Strikes; Eye; Eye Movements; Family; Fragile X Syndrome; Genetic Counseling; Heart; Heart Rate; Heterogeneity; Impairment; Individual; Infant; Investigation; Link; Measures; Methods; Neurocognitive; Neurosciences; Outcome; Paired Comparison; Pathway interactions; Pattern; Performance; Personal Satisfaction; Phase; Play; Population; Procedures; Process; Prospective Studies; Public Health; Publishing; Research; Resources; Response to stimulus physiology; Risk; Risk Factors; Role; Sampling; Services; Severities; Siblings; Specificity; Speed; Stimulus; Time; United States; Visual; Visual attention; Work; autism spectrum disorder; base; behavior measurement; computerized; cost; gaze; heart rate variability; high risk; high risk infant; infancy; innovation; longitudinal design; male; meetings; multilevel analysis; novel; preference; prospective; social; stimulus processing; visual tracking

Understanding the early predictors of autism is essential to promoting earlier identification, diagnosis and treatment. Although aberrant visual attention is one of the earliest identified predictors of autism and may play an integral role in the socio-communicative deficits inherent in the disorder, the emergence of atypical attention in infancy is poorly understood. The present proposal seeks to characterize the development of aberrant attention in autism by integrating cognitive and developmental neuroscience methods within a multiple-group, prospective longitudinal design. Methods will include computerized attention orienting and visual preference paradigms integrated with concurrently-measured heart-defined sustained attention. Integrating behavioral and heart-defined measures will critically inform whether behavioral eye movement reflects underlying cognitive processes of stimulus response. Patterns of behavioral and biomarkers will be compared across high risk infant siblings of children with autism (ASIBS), high risk infants with fragile X syndrome (FXS), and low risk controls; thus informing the etiological specificity of early attention indicators, which is essential to informing early diagnostic and treatment efforts. Specifically, we aim to: (1) evaluate group differences in attention orienting (disengagement, facilitation) and visual preference (social/nonsocial, novel/familiar) between 6, 9, and 12 months of age (9 and 12 months in FXS), (2) compare behavioral performance on computerized attention paradigms to heart-defined sustained attention, and (3) evaluate the relationship between autistic outcomes at 24 months and these early behavioral and biomarkers of attention. Multilevel modeling will be used to analyze the patterns of attention across high risk groups, as well as the relationship between early attention and autistic outcomes. This study is innovative in that it is the first to apply concurrently-measured behavioral and heart-defined attention to the prospective surveillance of infant attention in autism, as well as to compare behavioral and biomarkers of attention across high risk ASIBS and infants with FXS.

了解自闭症的早期预测因素对于促进早期识别、诊断和治疗至关重要。尽管异常的视觉注意力是最早发现的自闭症预测因素之一，并且可能在该疾病固有的社会沟通缺陷中发挥着不可或缺的作用，但婴儿期非典型注意力的出现却知之甚少。本提案旨在通过将认知和发展神经科学方法整合到多组前瞻性纵向设计中来描述自闭症异常注意力发展的特征。方法将包括计算机化的注意力定向和视觉偏好范式，与同时测量的心脏定义的持续注意力相结合。整合行为和心脏定义的测量将关键地告知行为眼动是否反映了刺激反应的潜在认知过程。将比较自闭症儿童的高风险婴儿兄弟姐妹（ASIBS）、患有脆性 X 综合征（FXS）的高风险婴儿和低风险对照的行为和生物标志物模式；从而告知早期注意指标的病因学特异性，这对于告知早期诊断和治疗工作至关重要。具体来说，我们的目标是：(1) 评估 6、9 和 12 个月大（FXS 中为 9 个月和 12 个月）之间注意力定向（脱离、促进）和视觉偏好（社交/非社交、新颖/熟悉）的群体差异，(2) 将计算机化注意力范式的行为表现与心脏定义的持续注意力进行比较，以及 (3) 评估 24 个月时的自闭症结果与这些早期行为和生物标志物之间的关系 注意力。多级建模将用于分析高风险群体的注意力模式，以及早期注意力与自闭症结果之间的关系。这项研究的创新之处在于，它首次将同时测量的行为和心脏定义的注意力应用于自闭症婴儿注意力的前瞻性监测，以及比较高风险 ASIBS 和 FXS 婴儿的注意力行为和生物标志物。

项目成果

Adaptive Skill Trajectories in Infants with Fragile X Syndrome Contrasted to Typical Controls and Infants at High Risk for Autism.

患有脆性 X 综合症的婴儿的适应性技能轨迹与典型对照组和自闭症高风险婴儿的对比。

• 发表时间: 2017-08
• 作者: Caravella, Kelly E;Roberts, Jane E
• 通讯作者: Roberts, Jane E

Brief Report: Autism Symptoms in Infants with Fragile X Syndrome.

简要报告：脆性 X 综合征婴儿的自闭症症状。

• 发表时间: 2016-12
• 影响因子: 3.9
• 作者: Roberts, Jane E;Tonnsen, Bridgette L;McCary, Lindsay M;Caravella, Kelly E;Shinkareva, Svetlana V
• 通讯作者: Shinkareva, Svetlana V