University of Louisville Center for Integrative Environmental Health Sciences

路易斯维尔大学综合环境健康科学中心

• 批准号: 10217134
• 负责人: J CHRISTOPHER STATES
• 金额: $ 132.6万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10217134
• 关键词: Adult; Agriculture; Alcohol consumption; Alcohols; Area; Basic Science; Biological Models; Biometry; Cardiovascular system; Chemicals; Childhood; Chronic; Chronic Disease; Clinical; Clinical Trials; Clinical Trials Unit; Collaborations; Communication; Communities; Complex; Core Facility; County; Development; Diabetes Mellitus; Diet; Disease; Disease Outcome; Ecosystem; Environment; Environmental Health; Environmental Risk Factor; Etiology; Exposure to; Funding; Gender; Genetic; Genetic Predisposition to Disease; Genotype; Geographic Locations; Goals; Grant; Health; Health Personnel; Health Sciences; Human; Individual; Industrialization; Informatics; Interdisciplinary Study; Interest Group; Investigation; Kentucky; Knowledge; Laboratories; Leadership; Life; Malignant Neoplasms; Measurement; Mental disorders; Mentors; Mentorship; Metals; Modification; Obesity; Pathogenesis; Pilot Projects; Play; Pollution; Polychlorinated Biphenyls; Positioning Attribute; Predisposition; Program Development; Research; Research Personnel; Research Training; Resources; Role; Rural; Toxic Environmental Substances; Toxicant exposure; Toxicology; Translating; Translations; United States; Universities; Vinyl Chloride; Vision; Youth; addiction; built environment; career development; citizen science; community based participatory research; community based research; community engagement; design; health science research; improved; lifestyle factors; man; member; metropolitan; multidisciplinary; next generation; pollutant; preventive intervention; programs; recruit; response; rural environment; rural healthcare; skills; socioeconomics; stressor; tobacco exposure; tobacco products; urban setting

The University of Louisville’s (UofL) Center for Integrative Environmental Health Science (CIEHS) brings together a multidisciplinary group of investigators working together to develop a framework to understand the complexities of and to integrate the interactions between environmental toxicants, life style factors, life stage, genetics and gender and their roles in human health and disease. The CIEHS is uniquely positioned to build transdisciplinary teams to tackle these problems by virtue of the multidisciplinary expertise of its members and its geographic location. The Louisville Regional Community, composed of Metropolitan Louisville and the counties of western Kentucky, is a unique mix of urban and rural environments with industrial and agricultural exposures that is a microcosm of the United States. The region is plagued by rates of chronic disease (e.g. cardiovascular, diabetes, cancer, etc.), all with environmental etiologies, that are among the highest in the nation. The CIEHS facilitates research and training focused on: (1) exposure to industrial chemicals present in the urban and rural KY environments (metals, VOCs, PCBs, vinyl chloride, etc.), (2) lifestyle factors (diet, alcohol, socioeconomic stressors, obesity, etc.), and the modifications to response by life stage, genetics and gender in development of chronic adult diseases. CIEHS is organized into three multi-disciplinary research interest groups (multi-organ toxicology, cancer, and neurodevelopmental toxicology). The Integrated Health Science Facility Core promotes translation of basic science including assistance with both adult and pediatric clinical trials. The Community Engagement Core promotes multi-directional communication between CIEHS investigators and community groups with special focus on rural health care providers and youth groups. The Pilot Project Program provides resources supporting new environmental health investigators, collaborations between CIEHS members and established investigators bringing new skill sets to environmental health problems, new avenues of environmental health research by CIEHS members, and community-engaged and community-led research in collaboration with CIEHS members. A Career Development Program provides mentorship and support to new junior, as well as mid-level, investigators. These activities are supported by two facility cores (biostatistics and informatics, and integrated toxicomics and environmental measurements). The CIEHS provides leadership in environmental health research, promotes investigation of the interactions of chronic exposure to environmental toxicants and lifestyle factors in pathogenesis, and develops the next generation of environmental health researchers. Our studies utilize model systems in the laboratory, the larger ecosystem by investigation of pollution effects on wildlife, and the human laboratory provided by the Louisville Regional Community in collaboration with community partners.

路易斯维尔大学（UOFL）综合环境健康科学中心（CIEHS）带来 一个多学科的研究人员共同努力，共同开发一个框架以了解 复杂性并整合环境有毒物质，生活方式因素，生命阶段之间的相互作用， 遗传学和性别及其在人类健康和疾病中的作用。 CIEHS独特地构建 跨学科团队通过其成员的多学科专业知识来解决这些问题 它的地理位置。路易斯维尔地区社区，由大都会路易斯维尔和 肯塔基州西部国家是城市和农村环境与工业和农业的独特组合 暴露是美国的缩影。该地区受到慢性疾病率的困扰（例如 心血管，糖尿病，癌症等），均具有环境病因，它们是最高的 国家。 CIEHS的最爱研究和培训的重点是：（1） 城市和粗糙的KY环境（金属，VOC，PCB，氯化乙烯基等），（2）生活方式因素（饮食，饮食， 酒精，社会经济压力源，肥胖等）以及对生命阶段，遗传学和遗传学的反应的修改 慢性成人疾病发展的性别。 CIEHS分为三个多学科研究 利益群体（多器官毒理学，癌症和神经发育毒理学）。综合健康 科学设施核心促进基础科学的翻译，包括在成人和小儿方面的帮助 临床试验。社区参与核心促进CIEHS之间的多向沟通 特别关注粗糙的医疗保健提供者和青年团体的调查人员和社区团体。 飞行员项目计划提供支持新的环境健康调查人员的资源，合作 在CIEHS成员和成熟的调查人员之间，将新技能推向环境健康 问题，CIEHS成员的环境健康研究的新途径，以及社区参与和 社区主导的研究与CIEHS成员合作。职业发展计划提供 对新少年以及中级调查人员的资术和支持。这些活动得到了两个 设施核心（生物统计学和信息，以及综合的毒物和环境测量）。 CIEHS在环境健康研究中提供领导才能，促进 长期暴露于发病机理中的环境有毒物质和生活方式因素，并发展下一个 产生环境健康研究人员。我们的研究利用实验室中的模型系统，越大 通过投资污染对野生动植物的投资以及路易斯维尔提供的人类实验室的生态系统 与社区合作伙伴合作的区域社区。