New mechanisms in axon regeneration

轴突再生的新机制

• 批准号: 10211489
• 负责人: MARC HAMMARLUND
• 金额: $ 41.33万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-15 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10211489
• 关键词: Address; Affect; Aging; Animal Model; Axon; Behavioral Assay; Biological; Caenorhabditis elegans; Cell physiology; Cells; Cellular biology; Complex; Data; Defect; Dendrites; Development; Developmental Process; Disease; Electron Microscopy; Failure; Genetic; Genomics; Goals; Human; Injury; Knowledge; Link; Location; MAPK8 gene; Maintenance; Mediating; Mitochondria; Molecular; Molecular Structure; Natural regeneration; Nervous System Trauma; Nervous system structure; Neuronal Injury; Neurons; Neurosciences; Outcome; Output; Pathway interactions; Process; Property; Public Health; Recording of previous events; Recovery of Function; Regulation; Research; Signal Transduction; Site; Structure; Synapses; System; Time; Work; axon injury; axon regeneration; cell growth regulation; experimental study; functional loss; functional restoration; genetic approach; healing; improved; in vivo; in vivo regeneration; insight; nerve injury; nervous system development; notch protein; novel; novel strategies; prevent; real-time images; reconstruction; restoration; synaptic function; synaptogenesis; targeted treatment; trafficking

PROJECT SUMMARY Axon regeneration is a fundamental and conserved property of nervous systems. But axon regeneration often fails to restore function after nerve injury. Thus, a key question in the field is to discover what determines the capacity of injured neurons to rebuild functional circuits. This proposal investigates new mechanisms that function in the injured neuron and that help determine whether or not effective regeneration occurs. The long-term goal is to gain a comprehensive understanding of the cellular functions that link neuronal injury to successful functional regeneration. The specific goal of this project is to analyze the process of synapse regeneration. The project uses a combination of in vivo approaches aimed at understanding how synapse regeneration works, why it fails to restore normal function, and how it can be improved. Completion of these Aims will describe fundamental cellular mechanisms that mediate functional axon regeneration after nerve injury.

项目摘要 轴突再生是神经系统的基本和保守的特性。但是轴突 神经损伤后的再生通常无法恢复功能。因此，该领域的关键问题是 发现什么决定了受伤神经元重建功能电路的能力。这 提案调查了在受伤神经元中起作用的新机制，并有助于 确定是否发生有效再生。长期目标是获得 对将神经元损伤与成功联系起来的细胞功能的全面理解 功能再生。该项目的具体目标是分析突触的过程 再生。该项目结合了旨在理解的体内方法 突触再生如何工作，为什么无法恢复正常功能以及如何恢复正常功能 改进。这些目标的完成将描述基本的细胞机制 神经损伤后介导功能性轴突再生。