Neuronal encoding of rapid categorical decisions across primate oculomotor networks

灵长类动眼神经网络快速分类决策的神经元编码

• 批准号: 10387364
• 负责人: Ou Zhu
• 金额: $ 5.18万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-15 至 2027-01-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10387364
• 关键词: Address; Agonist; Alzheimer' s Disease; Animals; Area; Arousal; Attention; Attention Deficit Disorder; Behavior; Behavioral; Brain; Brain Diseases; Brain region; Categories; Cognitive; Complement; Coupled; Decision Making; Disease; Environment; Evolution; Generations; Human; Impairment; Individual; Judgment; Laboratories; Lateral; Macaca mulatta; Measurable; Measures; Methodology; Modeling; Monkeys; Motion; Motor; Muscimol; Neurons; Performance; Pharmacology; Play; Population; Population Dynamics; Population Heterogeneity; Primates; Process; Psychophysics; Reaction Time; Research; Resolution; Role; Saccades; Schizophrenia; Sensory; Signal Transduction; Speed; Stimulus; Stroke; Structure; System; Tennis; Time; Visual; Visuospatial; Work; autism spectrum disorder; base; cognitive process; design; experimental study; frontal eye fields; information model; insight; lateral intraparietal area; millisecond; nervous system disorder; neural correlate; novel; oculomotor; receptive field; relating to nervous system; response; sensory discrimination; sensory stimulus; superior colliculus Corpora quadrigemina; visual information; visual motor; visual stimulus

Project Summary In a professional table tennis rally, the time between successive ping pong ball hits is around 400ms. Within this timeframe, the players must rapidly categorize the motion and spin of the ball to appropriately guide the ongoing motion of their paddle to successfully strike the ball. While numerous studies have investigated the oculomotor system’s role in the visual categorization process, few have done so where the response must be initiated in advance of relevant sensory information, such as in the aforementioned example. Thus, the temporal dynamics of sensory modulation of saccadic decisions remain largely unresolved. To identify the manner in which visual categorization informs ongoing motor plans, I propose recording neural activity from populations of neurons in the lateral intraparietal area (LIP), frontal eye field (FEF), and superior colliculus (SC) while monkeys perform a saccade-based motion categorization task in which motor planning always precedes the identification of the visual stimulus; consequently revealing the temporal evolution of a categorical judgment with millisecond resolution. Results from prior studies identified neurons in LIP and FEF that demonstrate categorical tuning, with increased firing rates when stimuli belonging to the preferred category appear on screen. Additionally, a recent study from our lab demonstrates the causal role of LIP in visual categorization in which reversible inactivation of LIP leads to significant deficits in categorization accuracy. However, the task structure utilized by these studies precludes any attempt to uncover the manner in which categorical signals influence ongoing motor plans, or identify differences in the timing and strength of categorical encoding between these brain regions. To date, no study has investigated categorical encoding in SC, thus we will be the first to identify its role in visual categorization. By simultaneously recording from large, diverse populations of neurons with linear arrays across these interconnected brain regions, the proposed research will provide critical insight into the temporal dynamics underlying the transformation of sensory evidence into oculomotor decisions.

项目摘要 在一次专业的乒乓球集会中，成功的乒乓球命中率约为400ms。之内 在这个时间范围内，球员必须迅速对球的运动和旋转进行归类，以适当地指导 他们的桨的持续动作成功地击球。尽管许多研究调查了 眼动系统在视觉类别过程中的作用，很少有响应必须是 在相关的感官信息之前（例如在近似示例中）启动。那， 囊性决策的感觉调制的临时动力学仍然在很大程度上尚未解决。识别 视觉类别信息正在进行的运动计划的方式，我提出了从 外侧室内区域（LIP），额眼场（FEF）和上丘（SC）中神经元的种群 虽然猴子执行基于扫视的运动类别任务，其中始终在其中之前 视觉刺激的识别；因此揭示了分类的暂时演变 通过毫秒决议法官。先前研究的结果确定了嘴唇和FEF中的神经元 演示分类调整，当属于首选类别的刺激时，发射速率提高 出现在屏幕上。此外，我们实验室的最新研究表明，嘴唇在视觉中的因果作用 分类的唇可逆失活导致类别准确性的重要定义。 但是，这些研究使用的任务结构无法揭示任何尝试 分类信号会影响正在进行的运动计划，或确定时间和强度的差异 这些大脑区域之间的分类编码。迄今为止，尚无研究研究 SC，因此我们将是第一个确定其在视觉类别中的作用的人。通过简单地从大录制 这些相互联系的大脑区域的神经元的潜水员种群，提议 研究将提供对感官转变基础的临时动态的重要洞察力 有证据表明动眼决定。