Neuronal encoding of rapid categorical decisions across primate oculomotor networks

灵长类动眼神经网络快速分类决策的神经元编码

• 批准号: 10387364
• 负责人: Ou Zhu
• 金额: $ 5.18万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-15 至 2027-01-14
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10387364
• 关键词: Address; Agonist; Alzheimer' s Disease; Animals; Area; Arousal; Attention; Attention Deficit Disorder; Behavior; Behavioral; Brain; Brain Diseases; Brain region; Categories; Cognitive; Complement; Coupled; Decision Making; Disease; Environment; Evolution; Generations; Human; Impairment; Individual; Judgment; Laboratories; Lateral; Macaca mulatta; Measurable; Measures; Methodology; Modeling; Monkeys; Motion; Motor; Muscimol; Neurons; Performance; Pharmacology; Play; Population; Population Dynamics; Population Heterogeneity; Primates; Process; Psychophysics; Reaction Time; Research; Resolution; Role; Saccades; Schizophrenia; Sensory; Signal Transduction; Speed; Stimulus; Stroke; Structure; System; Tennis; Time; Visual; Visuospatial; Work; autism spectrum disorder; base; cognitive process; design; experimental study; frontal eye fields; information model; insight; lateral intraparietal area; millisecond; nervous system disorder; neural correlate; novel; oculomotor; receptive field; relating to nervous system; response; sensory discrimination; sensory stimulus; superior colliculus Corpora quadrigemina; visual information; visual motor; visual stimulus

Project Summary In a professional table tennis rally, the time between successive ping pong ball hits is around 400ms. Within this timeframe, the players must rapidly categorize the motion and spin of the ball to appropriately guide the ongoing motion of their paddle to successfully strike the ball. While numerous studies have investigated the oculomotor system’s role in the visual categorization process, few have done so where the response must be initiated in advance of relevant sensory information, such as in the aforementioned example. Thus, the temporal dynamics of sensory modulation of saccadic decisions remain largely unresolved. To identify the manner in which visual categorization informs ongoing motor plans, I propose recording neural activity from populations of neurons in the lateral intraparietal area (LIP), frontal eye field (FEF), and superior colliculus (SC) while monkeys perform a saccade-based motion categorization task in which motor planning always precedes the identification of the visual stimulus; consequently revealing the temporal evolution of a categorical judgment with millisecond resolution. Results from prior studies identified neurons in LIP and FEF that demonstrate categorical tuning, with increased firing rates when stimuli belonging to the preferred category appear on screen. Additionally, a recent study from our lab demonstrates the causal role of LIP in visual categorization in which reversible inactivation of LIP leads to significant deficits in categorization accuracy. However, the task structure utilized by these studies precludes any attempt to uncover the manner in which categorical signals influence ongoing motor plans, or identify differences in the timing and strength of categorical encoding between these brain regions. To date, no study has investigated categorical encoding in SC, thus we will be the first to identify its role in visual categorization. By simultaneously recording from large, diverse populations of neurons with linear arrays across these interconnected brain regions, the proposed research will provide critical insight into the temporal dynamics underlying the transformation of sensory evidence into oculomotor decisions.

项目概要 在职业乒乓球比赛中，连续击球之间的时间在400ms左右。 在此时间范围内，球员必须快速对球的运动和旋转进行分类，以适当地引导球 球拍的持续运动才能成功击球，而大量研究对此进行了调查。 动眼系统在视觉分类过程中的作用，很少有人这样做，因为必须做出反应 在相关感官信息之前启动，例如在提到的示例中。 扫视决策的感觉调节的时间动力学在很大程度上仍未得到解决。 视觉分类告知正在进行的运动计划的方式，我建议记录神经活动 顶叶外侧区 (LIP)、额眼区 (FEF) 和上唇 (SC) 的神经元群 而猴子则执行基于扫视的运动分类任务，其中运动规划始终优先 视觉刺激的识别，从而揭示类别的时间演变； 先前研究的结果确定了 LIP 和 FEF 中的神经元 展示分类调整，当刺激属于首选类别时，放电率会增加 此外，我们实验室最近的一项研究证明了 LIP 在视觉中的因果作用。 LIP 的可逆失活导致分类准确性显着下降。 然而，这些研究使用的任务结构排除了任何试图揭示其方式的尝试。 分类信号影响正在进行的运动计划，或识别运动时间和强度的差异 迄今为止，还没有研究调查这些大脑区域之间的分类编码。 SC，因此我们将第一个通过同时记录大数据来确定其在视觉分类中的作用。 不同的神经元群体在这些相互连接的大脑区域中具有线性阵列， 研究将为感官转变背后的时间动态提供重要的见解 动眼神经决策的证据。