Massachusetts Alzheimer's Disease Research Center

马萨诸塞州阿尔茨海默病研究中心

• 批准号: 10378606
• 负责人: BRADLEY T. HYMAN
• 金额: $ 330.67万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-15 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10378606
• 关键词: Alzheimer' s Disease; Amyloid beta-Protein; Authorization documentation; Autopsy; Basic Science; Behavioral; Biological Assay; Biological Markers; Blood; Blood Vessels; Cerebrospinal Fluid; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Cognitive; Collaborations; Communities; Data; Data Linkages; Data Set; Dementia; Development; Diagnosis; Diagnostic Services; Disease; Education; Environment; Event; Faculty; Faculty Recruitment; Fertilization; Frontotemporal Dementia; Functional disorder; Future; General Hospitals; Goals; Heterogeneity; Image; Imaging Techniques; Impairment; Individual; Infrastructure; Institution; Knowledge; Laboratories; Leadership; Learning; Lesion; Lewy Body Disease; Link; MRI Scans; Marshal; Massachusetts; Measures; Mentors; Methods; Mission; Molecular Profiling; Natural Immunity; Nerve Degeneration; Neurofibrillary Tangles; Neuropsychology; Participant; Pathology; Patients; Phenotype; Plasma; Play; Population Heterogeneity; Positron-Emission Tomography; Process; Prognosis; Research; Research Methodology; Research Personnel; Research Support; Resources; Role; Sampling; Science; Scientist; Statistical Data Interpretation; Structure; Techniques; Technology; Testing; Therapeutic Trials; Training; Training Programs; Update; Work; base; biomarker validation; clinical biomarkers; clinical center; clinical phenotype; cohort; community setting; digital; disease heterogeneity; education research; follow-up; frontotemporal degeneration; imaging biomarker; imaging study; induced pluripotent stem cell; inflammatory marker; inter-individual variation; medical schools; mild cognitive impairment; multidisciplinary; neuroimaging; neuropathology; new technology; next generation; outreach; posters; programs; racial and ethnic; recruit; resilience; symposium; targeted biomarker; tau Proteins; therapeutic evaluation; therapeutic target; tool; validation studies

OVERVIEW: Massachusetts Alzheimer’s Disease Research Center (MADRC) The MADRC is an interdisciplinary Center at Massachusetts General Hospital, Harvard Medical School, with two major strategic goals: 1) to understand the underpinnings of heterogeneity of Alzheimer’s disease and Alzheimer’s Disease Related Disorders, and 2) to develop techniques, strategies, and technologies to accelerate a cure. To approach these goals, we propose 7 Cores (Administrative, Clinical, Biomarker, Imaging, Neuropathology, Data, and Outreach). We will use advanced Imaging, Biomarker, and analytic approaches to study our Research Cohort, which we view as a state of the art clinical phenotyping laboratory. Autopsy follow up for validation of biomarkers and imaging, and therapeutic targets, is essential. We plan to study a diverse population, both in the sense of various pathophysiologies, and also with varying racial and ethnic backgrounds, and rely on a vigorous ORE core both to fulfill our own recruitment needs and to support clinical trials and other affiliated programs. We have refocused our Center’s activities by remodeling the Research Cohort to include subjects who are cognitively normal, have mild cognitive impairment, or dementia, targeting diverse causes of dementia including Alzheimer’s disease and related disorders (Frontotemporal dementia, Lewy Body Disease, and vascular lesions). We postulate that heterogeneity of progression, even among individuals with the same “disease”, reflects underlying differences that can be uncovered, and that doing so will enhance clinical trial design by parsing variability from the very large, long cohort trials now in common use. Each Core is challenged to develop tools to help accelerate a cure – from intermediate imaging/biomarker targets that may help with diagnosis (a patient’s state) or prognosis (a patient’s fate), to performing autopsies to validate those targets. We will develop markers of inflammation and neurodegeneration, believing that innate immunity and resilience play a role in addition to tangles and plaques. Development of statistical and data methods are critical for anlaysis. These tools will allow us to test hypotheses about faster or slower rates of progression in a deeply phenotyped cohort. A final goal, central to our mission, is to build the future by training the next generation of scientists, which we propose to do under the framework of the Research Education Component. Together, we hope to make a difference in these devastating diseases.

概述：马萨诸塞州阿尔茨海默氏病研究中心（MADRC） Madrc是哈佛医学院马萨诸塞州综合医院的跨学科中心， 两个主要战略目标：1）了解阿尔茨海默氏病异质性的基础 阿尔茨海默氏病有关的疾病，以及2）开发技术，策略和技术 加速治疗。为了实现这些目标，我们提出了7个核心（行政，临床，生物标志物， 成像，神经病理学，数据和外展）。我们将使用高级成像，生物标志物和分析 研究我们的研究队列的方法，我们将其视为最先进的临床表型实验室。 验证生物标志物和成像以及治疗靶标的尸检是必不可少的。我们计划 从各种病理生理学的意义上，都研究多样性的人群，以及不同的种族和不同的种族和 种族背景，并依靠有力的矿石来满足我们自己的招聘需求并支持 临床试验和其他会员计划。 我们已经通过重塑研究队列将中心的活动重新调整了我们的活动 认知正常，具有轻度认知障碍或痴呆症，针对潜水员的痴呆原因 包括阿尔茨海默氏病和相关疾病（额颞痴呆，路易体疾病和 血管病变）。我们假设进步的异质性，即使 “疾病”，反映了可以发现的潜在差异，并且这样做将增强临床试验 通过解析非常大的队列试验的可变性来设计。 每个核心都面临开发工具以帮助加速治疗的工具 - 从中​​间成像/生物标志物 可能有助于诊断（患者的状态）或预后（患者的命运）的目标进行尸检 验证这些目标。我们将开发感染和神经变性的标记，认为 天生的免疫力和弹性在缠结和斑块上也起着作用。统计和开发 数据方法对于Anlaysis至关重要。这些工具将使我们能够检验有关更快或较慢速率的假设 深层表型队列中的进展。 我们使命的核心目标是通过培训下一代科学家来建立未来的最终目标，我们 在研究教育部分的框架下进行的建议。在一起，我们希望做一个 这些毁灭性疾病的差异。