Transcutaneous Direct Current Motor Nerve Block for Spasticity

经皮直流电机神经阻滞治疗痉挛

• 批准号: 10378663
• 负责人: Niloy Bhadra
• 金额: $ 40.25万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10378663
• 关键词: Action Potentials; Acute; Acute Pain; Affect; Axon; Caliber; Cerebral Palsy; Charge; Chronic; Clinical; Complication; Contracture; Data; Denervation; Development; Devices; Effectiveness; Electrodes; Electrolytes; Elements; Functional disorder; Future; Generations; Goals; Histology; Human; In Vitro; Injections; Interruption; Investigation; Ion Channel Gating; Local Anesthetics; Medical; Methods; Modality; Modeling; Monitor; Motor; Movement; Muscle; Muscle Hypertonia; Muscle Spasticity; Nerve; Nerve Block; Neural Conduction; Neurons; Operative Surgical Procedures; Oral; Oryctolagus cuniculus; Pathologic; Peripheral; Pharmaceutical Preparations; Pharmacology; Property; Rattus; Reaction; Recovery; Rehabilitation therapy; Rodent; Rodent Model; Safety; Short Interspersed Nucleotide Elements; Site; Skin; Spinal cord injury; Stroke; Surface; Temperature; Testing; Time; Tissues; Translating; Traumatic Brain Injury; Work; afferent nerve; autonomic nerve; base; channel blockers; chronic pain; chronic pain relief; clinical application; cost; design; disability; electric impedance; experimental study; flexibility; in vitro testing; in vivo; in vivo evaluation; innovation; limb movement; nerve damage; neurotransmission; nonhuman primate; novel; peroneal nerve; preclinical study; relating to nervous system; response; safety study; simulation; skin damage; skin irritation; spasticity; voltage

Uncoordinated or unwanted generation of nerve impulses is a major disabling factor in many medical conditions. These can affect motor, sensory, and autonomic nerves. Many of these pathological conditions could be ameliorated by interrupting these abnormal impulses in the periphery. The accepted methods of inhibiting neural activity are typically pharmacological (local anesthetics, oral medication, channel blockers, etc.) or surgical (denervation). Electrical nerve block has been proposed and evaluated as a means of providing real-time rapidly acting and rapidly reversing nerve block and is a potential candidate for inducing a reliable, rapid, gradable and reversible nerve block. Spasticity, or abnormally increased muscle tone, is a significant complication of stroke, cerebral palsy, spinal cord injury and traumatic brain injury. Spasticity causes significant disability including loss of movement, contractures and chronic pain. Electrical nerve block in the form of a non-invasive direct current block has been recently shown to produce motor block, when applied through the skin. This block has the properties of rapidity, reversibility and gradability, and repeatability. We propose an innovative direct current muscle block strategy delivered through the skin that will reduce spasticity and will aid in the rehabilitation of limb movement by reducing spasticity. The proposal focuses on development and testing of commercial and newly designed surface electrodes to show the efficacy of motor nerve block and investigate the parameters that deliver the direct current safely to both the skin and the target nerve.

神经冲动不协调或不必要的一代是许多医学的主要残疾因素 状况。这些会影响运动，感觉和自主神经。这些病理状况中的许多 可以通过中断外围的这些异常冲动来改善。接受的方法 抑制神经活动通常是药理学（局部麻醉药，口服药物，通道阻滞剂， 等）或手术（神经支配）。已经提出并评估电神经阻滞 提供实时迅速发挥作用并迅速逆转神经阻滞，是诱导的潜在候选者 可靠的，快速，可逆的和可逆的神经阻滞。 痉挛或异常增加的肌肉张力是中风的显着并发症，大脑麻痹， 脊髓损伤和脑外伤。痉挛会导致严重的残疾，包括移动丧失， 染色和慢性疼痛。非侵入性直流块形式的电神经阻滞具有 最近显示，当通过皮肤应用时会产生运动块。该块具有属性 快速，可逆性和渐进性以及可重复性。我们提出了创新的直流肌肉 通过皮肤传递的阻止策略，这将减少痉挛并有助于肢体康复 通过减少痉挛而运动。该提案着重于商业和新的开发和测试 设计表面电极以显示运动神经阻滞的功效并研究参数 将直流电流安全地传递到皮肤和靶神经。