Clinical Pharmacology Training Program

临床药理学培训项目

• 批准号: 10206154
• 负责人: WALTER K KRAFT
• 金额: $ 78.34万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10206154
• 关键词: Clinical Pharmacology; Training Programs

PROJECT SUMMARY/ABSTRACT This is a proposal to continue the evolution of postdoctoral training in clinical pharmacology as a collaborative program in pediatric and adult therapeutics in the joint program between Thomas Jefferson University (TJU) with the Children’s Hospital of Philadelphia (CHOP). The goal is to realize one key objective of the NIGMS-NICHD collaboration in clinical pharmacology as a leading joint program training clinician investigators to translate novel discoveries into therapeutic paradigms that transform disease management for children and adults. The program is designed for eight postdoctoral fellows, including MDs and MD-PhDs, and PharmDs, focused on human pharmacology and therapeutics. While training integrates therapeutics across the developmental continuum for fellows, half pursue careers in pediatric and half in adult clinical pharmacology to address shortages in these communities of practice nationally. The program, which is two years with the potential to extend for a third year, expands a well-established curriculum of didactic coursework, conferences, and rotations (20% effort) and research (80% effort). The breadth of pediatric and adult clinical pharmacology is delivered using a framework built on the TJU Training Program in Human Investigation (former NIH K30 Program). Courses cover clinical pharmacology, clinical trials design, statistics, pharmacoepidemiology, pharmacometrics, drug development, ethics, management, leadership, grant writing and presentation skills. Advanced training in academic and industrial pharmacometrics is an elective offering. Conferences include journal club in human therapeutics, research ethics, and seminars in human therapeutics. Rotations provide experience in the critical analysis of the scientific literature on the editorial board of the Annals of Internal Medicine; critical review of pediatric (CHOP) and adult (TJU) human subjects research on institutional review boards (IRBs); clinical trial execution in the TJU Clinical Research Unit; special issues in pediatric therapeutics on the CHOP formulary and investigational new drug (IND) committees, or analytic method development to support trainee pharmacokinetic studies. Fellows customize their education by selecting electives congruent with career aspirations, including drug development at Merck and/or rotation at the Food and Drug Administration (FDA). The majority of fellows’ time is focused on independent, hypothesis-driven research. Opportunities in pediatric and adult experimental therapeutics are offered by 54 preceptors representing 9 broad areas of distinction, including cancer, cardiopulmonary medicine, neurosciences, virology and immunology, connective tissue biology, pediatric oncology, systems and clinical pharmacology, gastroenterology, and pediatric therapeutics. Preceptors are selected based on their productive research programs related to therapeutics, training success, and commitment to train fellows. This program will continue to build upon an exemplary record of recruiting qualified diverse trainees who have been uniformly successful in academia, the biopharmaceutical industry, and FDA.

项目摘要/摘要 这是一项建议，旨在遏制临床药理学博士后培训的演变 托马森大学（TJU）之间的儿科和成人治疗计划与 费城儿童医院（CHOP）。 作为领先的联合计划培训克莱纳尼亚调查人员的临床药理学合作，以翻译小说 发现疾病的治疗范例，这些范例改变了该计划的疾病 专为八个博士后研究员，倾斜的MDS和MD-PHD和Pharmds设计，专注于人类 培训时，药理学和治疗疗法整合了整个发育连续性的治疗方法 研究员，一半从事小儿的职业，成人临床药理学的一半来解决这些短缺 全国实践社区，这是第三年的潜力 扩展了完善的教学课程，会议和轮换课程（20％的努力）和 研究（80％的努力）。 建立在人类调查的TJU培训计划（前NIH K30计划）上 药理学，临床试验设计，统计学，药物电子学，药物计量学，药物开发， 道德，管理，领导力，授予写作和演讲技巧。 工业药物计量学是一种抗管。 研究伦理和人类治疗学的研讨会。 内科纪事的编辑委员会的科学文献； （CHOP）和成人（TJU）人类受试者研究临床审查委员会（IRB）； 在TJU临床研究部门； 研究新药（IND）委员会或分析方法开发以支持受训者药代动力学 研究人员通过选择电气志向来定制他们的教育 默克公司的药物开发和/或旋转食品和药物管理（FDA）。 时间侧重于独立的假设驱动的研究。 治疗药由54个受体抑制9个广泛区别的受体提供，包括癌症， 心肺医学，神经科学，病毒学和免疫学，相关组织生物学，小儿 肿瘤学，系统和临床药理学，胃肠病和小儿治疗剂 根据他们的生产研究计划选择与治疗学，培训成功和凸轮有关 培训研究员。 Trainees Who Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho Ho