Training in Translating Neuroscience to Therapies

将神经科学转化为治疗的培训

基本信息

批准号：
10204266
负责人：
M. Maral Mouradian
金额：
$ 19.8万
依托单位：
RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10204266
关键词：
Neurosciences Training Translating

Neurosciences Training Translating

项目摘要

Project Summary This is a new program for “Training in Translating Neuroscience to Therapies” at Rutgers University. Its overall objective is to provide scientists in training performing laboratory-based experiments the skills and competencies needed to advance their discoveries to treatments for neurological disorders. The aims of the program are to: 1) provide a continuum of comprehensive training that advances translational neuroscience research towards therapeutic developments; 2) expand the pipeline of translational neuroscience researchers within a diverse cohort of trainees; and 3) leverage Rutgers’ strengths in neuroscience drug discovery and development to provide broad experiences to trainees in this program. The rationale for establishing this program is the increasing burden of neurological diseases globally, many of which have no good treatments much less cures, and the accelerated advances in scientific discoveries in the genetics and molecular pathogenesis of nervous system disorders. Thus, this is an opportune time to harness knowledge gained in our understanding of disease processes, fill in the gaps in this knowledge base, and translate basic discoveries to deliverables for patients suffering from these disorders. The design of the training program combines traditional coursework, seminars, conferences, a biostatistics curriculum, and an annual retreat, along with experiential learning through a series of apprenticeships with experts in fields that link scientific innovation with industry to advance laboratory discoveries to clinical trials. Trainees will learn from neurologists and trialists, and actively engage in clinical trials. The training period for each participant is two years. A total of two positions are requested in year one, and four positions in subsequent years. The trainees will include senior graduate students, MD/PhD students and postdoctoral fellows at a ratio of 1:1:2. Trainees will work in the laboratories of highly qualified neuroscientists and translational investigators employing multidisciplinary approaches to learn the principles of rigorous and reproducible research. They will also have mentors with expertise in medicinal chemistry, drug discovery and development, clinical research and trials, start-ups, and career opportunities. Faculty and trainees will benefit from a formal mentoring program in place at Rutgers Biomedical and Health Sciences. Program oversight includes internal and external advisory boards, and an Executive Committee consisting of senior leadership at Rutgers University with extensive experience in translational and clinical research, pharmaceutical development, commercialization of innovations, and graduate and postgraduate education. The quality and effectiveness of the training program will be assessed by an independent assessor. The intended outcome of this program is to train the next generation of leaders in translational neuroscience who have the knowhow and passion to take basic discoveries to clinical trials and treatments that benefit millions with neurological diseases.

项目摘要这是罗格斯大学（Rutgers University）的“将神经科学转化为疗法的培训”的新计划。它的整体目的是向科学家提供培训的基于实验室实验的技能和能力需要将他们的发现推向神经系统疾病的治疗。该计划的目的是：1）提供一系列全面培训，将转化神经科学研究推向治疗发展； 2）扩大潜水员转化神经科学研究人员的管道学员队列； 3）利用罗格斯在神经科学药物发现和发育方面的优势在该计划中为学员提供广泛的经验。建立此计划的理由是全球神经系统疾病的燃烧增加，其中许多没有良好的治疗方法，更少的治疗方法，以及神经遗传学和分子发病机理的科学发现的加速进步系统疾病。这是利用我们对疾病的理解中获得知识的机会过程，填补此知识库中的空白，并将基本发现转化为患者的可交付成果患有这些疾病。培训计划组合的设计传统课程，半小伙子，会议，生物统计学课程和年度务虚会，并通过一系列专家学习与领域专家的学徒制，这些专家将科学创新与行业联系起来，以推进实验室发现临床试验。学员将向神经科医生和试验员学习，并积极参与临床试验。每个参与者的培训期为两年。第一年总共要求两个职位和随后几年的四个职位。培训将包括高级研究生，医学博士/博士生和博士后研究员的比例为1：1：2。学员将在高素质的神经科学家的实验室中工作并翻译了采用多学科方法来学习严格和可再现的研究。他们还将拥有具有医学化学，药物发现和开发，临床研究和试验，初创企业和职业机会。教师和学员将受益从罗格斯生物医学和健康科学的正式心理计划中。程序监督包括内部和外部咨询委员会，以及由高级领导的执行委员会罗格斯大学（Rutgers University 创新的商业化以及研究生和研究生教育。质量和有效性培训计划将由独立评估员进行评估。该计划的预期结果是培训具有专门知识和热情的转化神经科学领导者临床试验和治疗的基本发现，使数百万神经系统疾病受益。