UW Center for Translational Muscle Research (Overall Application)

华盛顿大学转化肌研究中心（整体应用）

• 批准号: 10362588
• 负责人: THOMAS L. DANIEL
• 金额: $ 86.03万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-05 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10362588
• 关键词: Affect; Aging; Area; Award; Basic Science; Biological Assay; Biology; Biomechanics; Cell Respiration; Clinic; Clinical; Clinical Research; Collaborations; Communities; Connective Tissue; Core Facility; Data; Data Analyses; Development; Device or Instrument Development; Devices; Diabetes Mellitus; Disease; Educational workshop; Environment; Faculty; Fostering; Functional disorder; Funding; Genetic Diseases; Genomics; Goals; Health Status; Home; Image; Infrastructure; Institution; Interdisciplinary Study; International; Lead; Leadership; Malignant Neoplasms; Measurement; Measures; Mechanics; Metabolic; Metabolism; Mitochondria; Multiscale Mechanics; Muscle; Muscular Dystrophies; Myopathy; Nature; Neuromuscular research; Nursing Faculty; Pathologic; Pathology; Patient-Centered Care; Patients; Pediatric Hospitals; Peripheral; Physicians; Pilot Projects; Population; Principal Investigator; Proteomics; Public Health; Quality of life; Recording of previous events; Research; Research Personnel; Research Training; Resources; Scientist; Series; Services; Skeletal Muscle; Striated Muscles; Structure-Activity Relationship; Techniques; Technology; Testing; Therapeutic Agents; Tissues; Training; Translational Research; United States; Universities; Viral Vector; Washington; Work; base; bone; commercialization; computerized tools; cost; cost effective; data mining; early-career faculty; experience; high reward; high risk; improved; insight; interdisciplinary approach; interest; metabolomics; muscular structure; muscular system; new therapeutic target; news; novel; novel strategies; novel therapeutics; outreach; programs; recruit; research and development; single molecule; skill acquisition; skills; stem cell biology; success; therapeutic development; tool; tool development; treatment research

ABSTRACT - Overall The University of Washington (UW) is internationally known for its excellence in all aspects of skeletal muscle biology, especially in mechanistic and translational research of diseases. However, there is currently no centralizing resource that brings together all the muscle investigators from multiple departments for the benefit of facilitating and accelerating their efforts. Therefore we propose the UW Resource Center for Translational Muscle Research (CTMR) to provide a unifying resource and state of the art approaches to enhance skeletal muscle research at the UW. The proposed Center will offer tools, facilities and expertise in a combination available only at the UW to facilitate novel insights to muscle pathologies and move new therapeutics towards the clinic and the marketplace. This new Center will offer 4 cores (one administrative and three research resource) to provide tools and expertise in several areas of interest to current principal investigators. The Administrative Core (A) will provide program management and enrichment by providing a pilot project program, workshops, a seminar series, training and educational opportunities for new investigators and more experienced investigators moving into muscle research. The Mechanics and Devices Core (B) will provide state of the art measurements of muscle biomechanics at multiple levels of integration, and develop new assays for maturation and assessment of early stage muscle. The Metabolism and Energetics Core (C) will provide tools for in depth measures and analysis of metabolomics, energetics, cell respiration and mitochondrial function. The Computational and Quantitative Analysis Core (D) will provide computational and statistical tools for understanding disease, suggesting new therapeutic targets and understanding mechanisms. The CTMR will offer an environment to facilitate using integrative analysis, from single molecule dynamics through muscle structure-function relationships, with interdisciplinary approaches to advance skeletal muscle disease research and therapeutics development.

摘要 - 总体 华盛顿大学（UW）以其在骨骼肌肉各个方面的卓越表现而闻名 生物学，尤其是在疾病的机械和转化研究中。但是，目前没有 集中资源将来自多个部门的所有肌肉调查人员汇集在一起 促进和加速他们的努力。因此，我们提出了UW资源转化中心 肌肉研究（CTMR）提供了一种统一的资源和最新方法来增强骨骼 UW的肌肉研究。拟议的中心将组合提供工具，设施和专业知识 仅在UW上可用，以促进肌肉病理学的新颖见解，并将新的治疗剂转移到 诊所和市场。这个新中心将提供4个核心（一项行政和三项研究 资源）为当前主要研究人员提供一些感兴趣领域的工具和专业知识。这 行政核心（a）将通过提供试点项目计划来提供计划管理和丰富 讲习班，研讨会系列，培训和教育机会，为新调查人员和经验丰富 研究人员进入肌肉研究。力学和设备核心（b）将提供最先进的状态 在多个整合级别的肌肉生物力学测量 和评估早期肌肉。新陈代谢和能量核心（C）将为深度提供工具 代谢组学，能量学，细胞呼吸和线粒体功能的测量和分析。这 计算和定量分析核心（D）将为计算和统计工具提供 了解疾病，提出新的治疗靶标和理解机制。 CTMR会 提供一个环境，以促进使用整合分析，从单分子动力学到肌肉 结构功能关系，采用跨学科方法来推进骨骼肌疾病研究 和治疗学的发展。