The role of sexually dimorphic vasopressin in social behavior

性二态性加压素在社会行为中的作用

基本信息

批准号：
10363658
负责人：
Nicole Rigney
金额：
$ 4.68万
依托单位：
GEORGIA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-02-22 至 2024-02-21
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10363658
关键词：
Ablation Acute Address Adult Affect Aggressive behavior Anions Area Argipressin Behavior Behavior Disorders Behavioral Brain Brain region Cell physiology Cells Chemicals Chronic Communication Excision Exposure to Fellowship Female Functional disorder Genes Goals Grant Hypothalamic structure Incidence Investigation Lateral Libido Maternal Behavior Mediating Mental disorders Modernization Morbidity - disease rate Motivation Mus Neuroanatomy Neurons Neuropeptides Neurotransmitters Opsin Output Partner in relationship Play Population Prevalence Publications Research Personnel Role Sex Differences Sex Differentiation Site Social Behavior Social Behavior Disorders Social Controls Social Functioning Social Interaction Social support Source Steroids Structure of terminal stria nuclei of preoptic region Synapses System Techniques Testing Training Vasopressins Vertebrates Viral Virus autism spectrum disorder behavior test communication behavior experimental study genetic approach genetic manipulation knock-down male mind control nerve supply neural circuit neural network neuromechanism neuronal cell body neuroregulation optogenetics overexpression receptor relating to nervous system sex sexual dimorphism sexual role small hairpin RNA social social communication social relationships training opportunity

项目摘要

Project Summary This project aims to understand the function of sex difference in the neural control of social behavior by focusing on the sexually dimorphic vasopressin system, where males have much higher vasopressin expression than females. Experiments proposed during the fellowship period will identify whether the sex difference in vasopressin innervation contributes to sex differences in the control of social behavior and communication. I will gain exceptional training in powerful genetic approaches that allow us to target vasopressin cells and the vasopressin gene specifically. The first aim tests whether excitation or inhibition of the sexually dimorphic vasopressin cells in the bed nucleus of the stria terminalis (BNST) affects social behavior differently in males and females. The second aim tests whether vasopressin is the key neuropeptide mediating sex-different effects on social communication observed in a previous study that ablated BNST vasopressin cells. This project will significantly enhance our mechanistic understanding of how the brain controls social behavior differently in males and females and may explain why many behavioral disorders show striking sex differences in morbidity. Although recently major advances have been made in understanding the neural basis of social behavior in adulthood, how such behavior is controlled differently in males and females is, by and large, unknown. This training grant will address these issues.

项目摘要该项目旨在了解性别差异在社会行为神经控制中的功能专注于性二态加压素系统，男性具有更高的加压素表达比女性。奖学金期间提出的实验将确定性别是否加压素神经的差异有助于控制社会行为的性别差异和沟通。我将获得强大遗传方法的卓越培训，使我们能够定位血管加压素细胞和加压素基因特别。第一个目标测试是激发还是抑制斯特里斯末端（BNST）的床核中的性二态加压素细胞影响社会男性和女性的行为不同。第二个目标测试加压素是否是关键神经肽在先前的研究中观察到的对社会沟通的介导对社会交流的影响加压素细胞。该项目将大大增强我们对大脑如何的机械理解在男性和女性中以不同的方式控制社会行为，可以解释为什么许多行为障碍表现出来发病率的性别差异。尽管最近在了解成年后社会行为的神经基础，男性和女性如何控制这种行为总的来说，未知。该培训补助金将解决这些问题。