The prevalence of diagnosed and undiagnosed Alzheimer's disease and related dementias among Arab Americans

阿拉伯裔美国人中已诊断和未诊断的阿尔茨海默病及相关痴呆症的患病率

• 批准号: 10362682
• 负责人: Tiffany Billmeier Kindratt
• 金额: $ 7.7万
• 依托单位: UNIVERSITY OF TEXAS ARLINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-15 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10362682
• 关键词: Address; Adult; Advocate; Affect; Age; Aging; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; American; Arabs; Asian population; Attention; Birth Place; Black Populations; Caribbean Hispanic; Classification; Code; Cognitive; Community Surveys; Complement; Data; Data Set; Data Sources; Development; Diabetes Mellitus; Diagnosis; Discrimination; Ethnic Origin; Ethnic group; Europe; Expenditure; Federal Government; Fibrinogen; Fostering; Health; Health Surveys; Hispanic Populations; Household; ICD-9; Immigrant; Individual; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Intervention; Knowledge; Link; Literature; Logistic Regressions; Measures; Medical; Mental Depression; Methods; Mexican Americans; Middle East; Minority Groups; Mission; Modeling; National Health Interview Survey; National Institute on Aging; Northern Africa; Not Hispanic or Latino; Outcome; Patient Self-Report; Persons; Policies; Population; Prevalence; Procedures; Provider; Psyche structure; Public Health; Race; Reporting; Research; Research Personnel; Resources; Sampling; Scientist; Surveys; System; United States Agency for Healthcare Research and Quality; Vulnerable Populations; Work; base; cognitive disability; dementia risk; disability; epidemiology study; ethnic minority population; experience; improved; innovation; racial and ethnic; racial and ethnic disparities; racial minority; response; sex; social

PROJECT SUMMARY/ABSTRACT The national prevalence of diagnosed and undiagnosed Alzheimer’s disease and related dementias (ADRD) among Arab Americans is unknown. Estimates are unknown because Arab Americans are considered non- Hispanic (NH) whites in national health surveys. By using innovative methods to link National Health Interview Survey (NHIS) and Medical Expenditure Panel Survey (MEPS) data, we can disaggregate Arab Americans from the NH white classification to uncover ADRD estimates. Specific aims are to: 1) estimate the age- and sex-adjusted prevalence of diagnosed ADRD among foreign-born Arab Americans compared to US-born NH whites and foreign-born NH whites, NH blacks, NH Asians and Hispanics; 2) examine associations between race, ethnicity and nativity status and the prevalence of diagnosed ADRD before and after controlling for covariates; 3) estimate the age- and sex-adjusted prevalence of undiagnosed ADRD among Arab Americans compared to the aforementioned groups; and 4) examine associations between race, ethnicity and nativity status and the prevalence of undiagnosed ADRD before and after controlling for covariates. Secondary, cross-sectional data from 2000-2016 NHIS and 2001-2017 MEPS data sources will be combined and analyzed. Responses will be matched, and a linked dataset will be created by the Agency for Healthcare Research and Quality. The sample will include adults >45 years. The independent variable will be created by combining questions assessing race, ethnicity and nativity status from NHIS. Foreign-born Arab Americans will be compared to US-born NH whites and foreign-born NH whites, NH blacks, NH Asians and Hispanics. For Aims 1 and 2, the dependent variable is diagnosed ADRD, measured using data from MEPS medical condition files. Adults with ICD-9 codes 290, 294, 331, 797 (2001-2015) or ICD-10 codes F03 or G30 (2016-2017) will be classified as has having diagnosed ADRD. For Aims 3 and 4, the dependent variable is undiagnosed ADRD, measured using MEPS medical condition and household component files. The MEPS asks three questions to estimate cognitive limitations, an indicator of ADRD. Adults will be categorized as having undiagnosed ADRD if: 1) they responded “yes” to one or more questions on cognitive limitations and 2) do not have diagnosed ADRD. Age and sex adjusted prevalence of diagnosed ADRD (Aim 1) and undiagnosed ADRD (Aim 3) will be calculated for Arab Americans compared to US-born NH whites and foreign-born NH whites, blacks, Hispanics and Asians. Logistic regression will be used to determine associations between the combined race, ethnicity and nativity status variable and diagnosed ADRD (Aim 2), and undiagnosed ADRD (Aim 4) before and after controlling for covariates. The innovative method used in this study will contribute the first estimates of diagnosed and undiagnosed ADRD among Arab Americans to the medical literature. Results will help to facilitate policy decisions and advocate for resources to be allocated for interventions to improve the health of this underrepresented but increasingly visible vulnerable population.

项目摘要/摘要 诊断和未诊断的阿尔茨海默氏病和相关痴呆症（ADRD）的全国患病率（ADRD） 在阿拉伯美国人中，未知。估计是未知的，因为阿拉伯美国人被认为是非 国家健康调查中的西班牙裔（NH）。通过使用创新方法将国家健康访谈联系起来 调查（NHIS）和医疗支出小组调查（MEP）数据，我们可以分解阿拉伯美国人 从NH白色分类到发现ADRD估计。具体目的是：1）估计年龄和年龄 与美国出生的NH相比 白人和外国出生的NH白人，NH黑人，NH亚洲人和西班牙裔； 2）检查之间的关联 在控制之前和之后，种族，种族和诞生状况以及被诊断为ADRD的患病率 协变量； 3）估计阿拉伯美国人中未诊断的ADRD的年龄和性别调整的患病率 与理性群体相比； 4）检查种族，种族和诞生之间的关联 在控制协变量之前和之后，状态和未诊断的ADRD的流行率。次要 2000 - 2016年NHIS和2001-2017 MEPS数据源的横截面数据将合并，并且 分析。响应将匹配，并将由医疗机构创建链接的数据集 研究和质量。样本将包括成年人> 45年。独立变量将创建 通过结合评估种族，种族和诞生状况的问题。外国出生的阿拉伯人 美国人将与美国出生的NH白人和外国出生的NH白人，NH黑人，NH亚洲人和 西班牙裔。对于目标1和2，将因变量诊断为ADRD，使用来自 MEPS医疗状况文件。 ICD-9代码的成年人290、294、331、797（2001-2015）或ICD-10代码F03 或G30（2016-2017）将被归类为诊断ADRD。对于目标3和4，依赖 变量是未诊断的ADRD，使用MEPS医疗状况和家庭组件测量 文件。 MEP提出了三个问题来估计认知局限性，这是ADRD的指标。成人会 归类为未经诊断的ADRD，如果：1）他们对一个或多个关于认知问题的问题“是”回答 限制和2）未诊断出ADRD。诊断为ADRD的年龄和性别调整的患病率（AIM 1） 与美国出生的NH白人相比，将针对阿拉伯美国人计算未诊断的ADRD（AIM 3） 外国出生的NH白人，黑人，西班牙裔和亚洲人。逻辑回归将用于确定 合并种族，种族和耶稣降生状态变量与被诊断的ADRD之间的关联（AIM 2）， 并在控制协变量之前和之后未被诊断的ADRD（AIM 4）。此中使用的创新方法 研究将对阿拉伯美国人中被诊断和未诊断的ADRD进行最初的估计 医学文献。结果将有助于促进政策决策，并主张分配资源 改善这种代表性不足但越来越明显的脆弱人群的干预措施。

项目成果

Diabetes Among Racial and Ethnically Diverse Older Adults in the United States with Cognitive Limitations.

美国不同种族和民族的老年人中认知受限的糖尿病。

• DOI: 10.1007/s40615-023-01514-8
• 发表时间: 2024
• 期刊: Journal of racial and ethnic health disparities
• 影响因子: 3.9
• 作者: Kindratt,TiffanyB;Moncriffe,Berford;Ajrouch,KristineJ;Zahodne,LauraB;Dallo,FlorenceJ
• 通讯作者: Dallo,FlorenceJ

Modifiable Risk Factors for Alzheimer's Disease and Related Dementias Among Middle Eastern and North African Immigrants to the United States.

美国中东和北非移民中阿尔茨海默病和相关痴呆症的可改变危险因素。

• DOI: 10.1093/geroni/igae025
• 发表时间: 2024
• 期刊: Innovation in aging
• 影响因子: 7
• 作者: Kindratt,TiffanyB;Zahodne,LauraB;Ajrouch,KristineJ;Dallo,FlorenceJ
• 通讯作者: Dallo,FlorenceJ

Suitability of Middle Eastern and North African immigrant minimal reporting category for Arab immigrant health research in the national health interview survey.

国家健康访谈调查中中东和北非移民最低报告类别对阿拉伯移民健康研究的适用性。

• DOI: 10.1016/j.socscimed.2023.116260
• 发表时间: 2023
• 期刊: Social science & medicine (1982)
• 作者: Dallo,FlorenceJ;Kindratt,TiffanyB;Ajrouch,KristineJ
• 通讯作者: Ajrouch,KristineJ

Improving the Collection of National Health Data: The Case for the Middle Eastern and North African Checkbox in the United States.

改进国家健康数据的收集：以美国中东和北非复选框为例。

• DOI: 10.21203/rs.3.rs-2790994/v2
• 发表时间: 2023
• 期刊: Research square
• 作者: Kindratt,TiffanyB

Health information technology use among foreign-born adults of Middle Eastern and North African decent in the United States.

美国中东和北非裔外国出生成年人对健康信息技术的使用情况。

• DOI: 10.21203/rs.3.rs-3491745/v1
• 发表时间: 2023
• 期刊: Research square
• 作者: Smith,Alexandra;Kindratt,Tiffany
• 通讯作者: Kindratt,Tiffany