Neuroimmunology of Disease Training Program

疾病神经免疫学培训计划

• 批准号: 10200159
• 负责人: Howard E Gendelman
• 金额: $ 18.99万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200159
• 关键词: Disease; Training Programs; neuroimmunology

ABSTRACT Despite advances in basic and translational neuroscience research, the development of new therapeutics remains in want. The National Institutes of Health has recognized the need to translate bench research to therapies that improve human disease outcomes and initiated programs that train researchers who can effectively conceptualize neurological disease processes. One critical “in need” area is in the discipline of neuroimmunity. This research area remains understudied despite its close linkage to the pathobiology of degenerative, infectious, developmental, and psychiatric disorders. To these ends, our training goal is to provide talented students with a fundamental understanding of peripheral and central immunology as it affects neuronal injury, differentiation, regeneration, and protection. The program is designed to provide the student with broad exposure to research methods that facilitate technical proficiency. The program ensures that the student will acquire broad knowledge in neuroimmunity. This would allow critical thinking for how inflammation affects the pathogenesis and treatment of neurological disorders. Several approaches are proposed to achieve this goal. First, is the use of our newly published textbook Neuroimmune Pharmacology (2nd Ed.) designed specifically as a coursework guide in neuroscience, immunology, and pharmacology. Second, is in developing a cross discipline mentorship training to provide the student with opportunities to intersect studies of immunity and neural function. Third, are “unique” research experiences in systems biology, cell signaling, glial and neuronal biology, human disease models and synaptic physiology. These opportunities serve to complement research in neural genetics, development, repair, and pharmacology. Fourth, are formal student presentations to interdisciplinary basic neuroscientists and supervisory committees to acquire research feedback in design, interpretation and conceptualization of ongoing research activities. This serves to challenge existing paradigms and existing student perceptions. Fifth, are uniquely offered cross-discipline team mentoring, teaching, and clinical neurological experiences. Sixth, are cross-disciplinary internships where students will complete thesis component(s) in another laboratory using a different research approach and mentor. Seventh, are sustained community, university and logistical support. By coordinating the training efforts of divergent research groups linked by common interests in neuroimmunity trainees will develop deeper understandings of innate and adaptive immunity in relationship to neurologic disease. Such trainees will be better prepared to develop successful careers in studies of disease pathobiology and therapeutic interventions for human nervous system disorders.

抽象的 尽管基本和转化神经科学研究取得了进步，但新疗法的发展 脂肪仍在脂肪中。 改善人类疾病结果的疗法培训研究人员可以 有效概念化神经疾病过程。 神经免疫性。 退化，感染性，发育性，安氏病，我们的培训目标是 为有才华的学生提供对外围和中心免疫学的基本了解。 神经元损伤，区分，再生和保护旨在为学生提供。 通过广泛接触促进技术实践的研究方法。 学生将获得广泛的神经免疫知识。 影响神经系统疾病的发病机理和治疗。 这个目标是使用我们新的教科书神经药理学（第二版） 特别是作为神经科学，免疫学和药理学指南。 跨学科指导培训，为学生提供与免疫力相交的机会 和神经功能。 神经元生物学，人类疾病模型和突触生理学。 神经遗传学，开发，维修和药理学的研究是正式的学生生存 跨学科的基本基本神经科学家和监督委员会，以获取设计的研究反馈， 正在进行的研究活动的解释和概念化。 和八分之一的学生的看法。 临床神经学经验是跨学科实习 使用不同的研究和指导者在另一个实验室中的组成部分。 社区，大学和后勤支持。 在神经免疫学员的共同利益方面，将对先天和 与神经系统疾病的关系适应性免疫。 在某些病理生物学和人类神经系统治疗干预措施中，成功的职业 疾病。