Bone Histology and Imaging

骨组织学和成像

基本信息

批准号：
10357775
负责人：
ROY MORELLO
金额：
$ 23.62万
依托单位：
UNIV OF ARKANSAS FOR MED SCIS
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-02-16 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10357775
关键词：
Animals Architecture Arkansas Bioinformatics Biology Body Composition Bone Tissue CRISPR/Cas technology Centers of Research Excellence Data Development Disease Dual-Energy X-Ray Absorptiometry Educational Activities Educational workshop Endocrinology Engraftment Ensure Equipment Faculty Finite Element Analysis Foundations Freezing Gene Expression Genetic Genetic Models Genetic Research Geometry Goals Histologic Histological Techniques Histology Human Human Resources Image In Situ Knowledge Laboratories Leadership Measurement Measures Medical Mentors Metastatic Neoplasm to the Bone Microtomy Minerals Modernization Molecular Mus Musculoskeletal Musculoskeletal Diseases Musculoskeletal System Orthopedic Surgery Orthopedics Osteomyelitis Osteoporosis Paraffin Embedding Pathologic Patients Phenotype Plastic Embedding Porosity Process Productivity Program Research Project Grants RNA Research Research Personnel Research Project Grants Resolution Resources Sampling Science Services Skeleton Stains Supervision System Technology Tissues Training Training Support Universities X-Ray Medical Imaging analytical tool biomechanical test bone bone imaging bone mass bone strength cortical bone design experience experimental study faculty research fluorescence imaging histological studies imaging modality in vivo bioluminescence imaging investigator training member mouse model musculoskeletal imaging neoplastic cell new technology recruit research facility skeletal soft tissue substantia spongiosa success tomography

项目摘要

PROJECT SUMMARY/ABSTRACT The proposed Center for Musculoskeletal Disease Research (CMDR) at the University of Arkansas for Medical Sciences (UAMS) includes the establishment of the Bone Histology and Imaging Core (Core C). The scientific theme of the proposed CMDR is the identification of the molecular causes of diseases and conditions that negatively impact the musculoskeletal system or interact with this system as part of their disease process. The Bone Histology and Imaging Core is consistent with this theme in that it will deliver to the Project Leaders state-of-the-art quantitative tissue and cellular data for the characterization of the structural, tissue, and cellular changes that underlie the pathological mechanisms of the musculoskeletal diseases being studied. The Bone Histology and Imaging Core will therefore be a critical component for the success of the Project Leaders. The Core will consolidate existing equipment on the UAMS campus into a large, modern research space within the Department of Orthopaedic Surgery and will hire experienced personnel on the campus, which will be supervised by a Core Leader. The specific aims are: 1) To establish the Bone Histology and Imaging Core; 2) To deliver state-of-the-art musculoskeletal imaging, biomechanical testing, and histology services and introduce new analytical technologies to CMDR Project Leaders and faculty; 3) To provide bone histomorphometry training and support educational activities. The success of the Bone Histology and Imaging Core, in conjunction with the other CMDR cores, will support the development of a critical mass of investigators that will ensure the long-term sustainability and productivity of the Center.

项目摘要/摘要阿肯色大学拟议的肌肉骨骼疾病研究中心（CMDR）医学科学（UAMS）包括建立骨组织学和成像核心（核心C）。这提出的CMDR的科学主题是鉴定疾病和状况的分子原因这会对肌肉骨骼系统产生负面影响或作为其疾病过程的一部分与该系统相互作用。骨骼组织学和成像核心与该主题一致，因为它将传达给项目领导者最先进的定量组织和细胞数据，用于表征结构，组织和细胞研究的变化是正在研究的肌肉骨骼疾病的病理机制。骨头因此，组织学和成像核心将成为项目领导者成功的关键组成部分。这核心将使UAMS校园的现有设备合并为一个大型现代研究空间骨科手术系，将在校园内雇用经验丰富的人员，将受到监督由核心领导者。具体目的是：1）建立骨组织学和成像核心； 2）交付最先进的肌肉骨骼成像，生物力学测试和组织学服务，并引入新 CMDR项目领导者和教职员工的分析技术； 3）提供骨骼组态计量学训练和支持教育活动。骨组织学和成像核心的成功与另一个 CMDR核心将支持大量研究人员的发展，以确保长期中心的可持续性和生产力。