Administrative Core

行政核心

• 批准号: 10198008
• 负责人: Paul Wesley Noble
• 金额: $ 12.52万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198008
• 关键词: Adherence; Allografting; Animal Model; Chronic; Disease; Disease Progression; Epithelial; Functional disorder; Goals; Human; Lung; Mesenchymal; Physicians; Productivity; Pulmonary Fibrosis; Regulation; Research Personnel; Sampling; Scientist; United States National Institutes of Health; Work; combat; idiopathic pulmonary fibrosis; improved; lung allograft; new therapeutic target; programs; skills

PROJECT SUMMARY The purpose of the Program is to bring together a team of investigators to focus on the pathobiology of two important disease states, Chronic Lung Allograft Dysfunction and idiopathic pulmonary fibrosis using both state-of-the-art animal modeling and human samples. The goals of this Program are to improve our understanding of the mechanisms that contribute to disease progression and identity novel therapeutic targets to combat lung fibrosis whether it occurs in the airway or in the interstitium of the lung. The Program brings together a team of scientists and physician scientists with complementary skills to work as a unit on these important problems. In order to coordinate these efforts, we propose an Administrative Core to facilitate interactions and adherence to NIH regulations regarding management of PO1 proposals. We propose the following Specific Aims:  Coordinate and facilitate administration of the Program between Project Leaders and Core Leaders.  Coordinate and facilitate administration of the Program between investigators, internal and external advisors and an enrichment program organized to maximize scientific productivity.

项目摘要 该计划的目的是召集一个调查人员团队，以专注于两个 重要疾病状态，慢性肺同种异体功能障碍和特发性肺纤维化都使用 最先进的动物建模和人类样品。该计划的目标是改善我们的 了解有助于疾病进展和认同的机制新型治疗靶标 对抗肺纤维化，无论是发生在气道还是在肺的间质中。该程序带来 一组科学家和身体科学家团队具有完整的技能，可以作为一个单位工作 重要问题。为了协调这些努力，我们提出了一个行政核心来促进 互动和遵守有关PO1建议管理的NIH法规。我们建议 遵循特定目的： 协调和促进项目领导者和核心领导者之间的计划。 协调和促进调查人员，内部和外部之间的程序 顾问和一个充实计划，旨在最大化科学产品。