Neuroplasticity in Auditory Aging

听觉衰老中的神经可塑性

• 批准号: 10198720
• 负责人: Sandra M Gordon-Salant
• 金额: $ 164.18万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198720
• 关键词: Acoustics; Activities of Daily Living; Address; Adult; Affect; Aging; American; Anatomy; Animals; Attention; Auditory; Auditory Evoked Potentials; Auditory area; Auditory system; Behavior; Behavioral; Biological Models; Brain; Brain Stem; Chemicals; Chronic; Clinical; Code; Cognition; Cognitive; Communication; Crystallization; Data Analyses; Detection; Development; Devices; Discrimination; Elderly; Electrophysiology (science); Environment; Equilibrium; Evaluation; Goals; Health; Healthy People 2020; Hearing; Hearing Aids; Human; Human Subject Research; Image; Impaired cognition; Individual; Intervention; Investigation; Life; Link; Maryland; Measures; Mental Depression; Methodology; Modeling; Monitor; Mus; Neuronal Plasticity; Noise; Outcome; Outcome Measure; Participant; Pattern; Performance; Population; Presbycusis; Problem Solving; Procedures; Process; Program Research Project Grants; Protocols documentation; Quality of life; Regimen; Research Personnel; Scientist; Sensory; Short-Term Memory; Signal Transduction; Social isolation; Speech; Speech Perception; Speed; Stimulus; System; Talents; Training; Training Technics; Universities; Variant; Work; age effect; age related; audiovisual speech; auditory pathway; auditory processing; base; behavior measurement; behavioral outcome; cognitive ability; cognitive system; cognitive training; executive function; experience; hearing impairment; improved; indexing; information processing; interest; neuromechanism; normal hearing; programs; relating to nervous system; remediation; response; selective attention; sensory system; signal processing; speech recognition; stem; support network; two-photon

ABSTRACT: OVERALL Significant hearing loss among older Americans exceeds 50%, suggesting that age-related hearing loss (ARHL) is one of the most common chronic health conditions experienced by older people. Untreated hearing loss is linked to depression, social isolation, and cognitive decline. While hearing aids remain the primary device for improving communication for those with ARHL, the take-up rate is relatively low at about 25%. Understanding speech in degraded listening situations (e.g., noise, reverberation, fast speech) continues to be a major challenge for older people, even among those with normal hearing. The underlying problem stems from limitations in the auditory periphery, the central auditory pathways, cognitive abilities, and alterations in the auditory-cognitive networks that support processing of auditory signals in noise and other forms of stimulus degradation. While a broad understanding of the problems experienced by older people is crystallizing, efforts to alleviate the problem through systematic investigation have been sparse. Thus, the over-arching goal of this Program Project Grant is to develop an integrative model of neuroplasticity in auditory aging, which will identify beneficial intervention strategies for mitigating the impact of auditory -cognitive decline with aging and will identify key loci of change in the auditory pathways that correlate with the most positive outcomes. The focus is on adaptive behavioral training to 1) enhance the auditory attention network to improve selective attention to relevant information and to suppress irrelevant information; 2) re-establish the appropriate balance between excitatory and inhibitory firing patterns to enhance auditory processing and cognition; and 3) improve neural timing to enhance precision of coding of acoustic stimuli to improve acoustic scene analysis and speech recognition. These targeted indices of positive neural plasticity will be monitored through a systems approach using behavior, electrophysiology, and imaging with humans and animals. The program includes 3 projects (P1: (Listening in noise, clutter, and reverberant environments – central effects of aging and approaches to remediation; P2: Auditory temporal processing; P3: Speech Perception Training with High Cognitive Demand) and 3 cores (Core A: Administrative; Core B: Signal Processing and Data Analysis; Core C: Human Subjects Research Core), and involves 9 highly collaborative auditory and cognitive neuroscientists with a dedicated interest in solving the problems of speech communication with aging. If successful, the program has the potential to restore successful communication and improve quality of life for millions of older Americans.

摘要：总体 老年人的大幅听力损失超过50％，这表明与年龄有关 听力损失（ARHL）是最常见的慢性健康状况之一 老年人。未经治疗的听力损失与抑郁，社会隔离和认知有关 衰退。尽管助听器仍然是改善这些人沟通的主要手段 使用ARHL，大约25％的增加率相对较低。了解语音 退化的听力情况（例如噪音，恢复，快速语音）继续是主要的 对老年人的挑战，即使是正常听力的人。潜在问题 源于听觉外围的局限性，中央听觉途径，认知 能力以及支持听觉处理的听觉认知网络的更改 噪声和其他形式的刺激降解中的信号。虽然对 老年人遇到的问题正在结晶，努力通过 系统投资很少。这是该计划的整理目标 授予项目是在听觉衰老中开发神经可塑性的综合模型，该模型 将确定有益的干预策略来减轻听觉认知的影响 随着衰老的衰落，将确定相关的听觉途径的关键本地变化 最积极的结果。重点是自适应行为训练1）增强 听觉注意网络，以提高对相关信息的选择性关注和 抑制无关的信息； 2）重新建立兴奋性之间的适当平衡 和抑制性射击模式，以增强听觉处理和认知； 3）改进 神经时间安排提高声学刺激编码的精度以改善声学场景 分析和语音识别。这些阳性神经可塑性的目标指标将是 使用行为，电生理学和成像通过系统方法监测 人类和动物。该程序包括3个项目（P1 ：（聆听噪音，混乱和 混响环境 - 衰老和补救方法的核心影响； P2： 听觉临时处理； P3：具有高认知需求的语音感知培训） 和3个核心（核心A：管理；核心B：信号处理和数据分析；核心C： 人类受试者研究核心），并涉及9个高度协作的听觉和认知 神经科学家对解决语音交流的问题非常感兴趣 随着衰老。如果成功，该计划有可能恢复成功的沟通 并改善数百万美国人的生活质量。