Early Life Conditions, Work, Psychological Wellbeing, Cognition and Dementia Risk

早期生活状况、工作、心理健康、认知和痴呆风险

• 批准号: 10192630
• 负责人: Arie Kapteyn
• 金额: $ 41.29万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10192630
• 关键词: Adult; Adverse event; Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Attention; Beginning of Life; Birth; Businesses; Cessation of life; Childhood; Climacteric; Cognition; Cognitive; Country; Data; Dementia; Developed Countries; Disability Insurance; Economic Policy; Education; Elderly; Environment; Europe; European; Event; Evolution; Factor Analysis; Family; Health; Health Surveys; Health and Retirement Study; Height; Impaired cognition; Individual; Infant Mortality; Institution; Israel; Laws; Lead; Life; Life Cycle Stages; Life Expectancy; Link; Longitudinal Studies; Longitudinal Surveys; Maternal and Child Health; Mental Depression; Modeling; Nature; Nursery Schools; Older Population; Outcome; Patient Self-Report; Pensions; Personal Satisfaction; Physical environment; Plant Roots; Policies; Regulation; Reporting; Residential Mobility; Respondent; Retirement; Risk Factors; Role; School-Age Population; Source; Spouses; Surveys; Time; United Kingdom; United States; Variant; Well in self; Western World; Work; Workplace; World War II; cognitive function; contextual factors; data harmonization; dementia risk; end of life; experience; gender difference; health care availability; interest; life history; middle age; novel; programs; protective factors; satisfaction; socioeconomics

Rising life expectancy is contributing to rapid increases in the size of the older population and is expected to lead to a sharp rise in dementia cases, from about 47 million people worldwide today, to potentially more than 140 million in 2050. In this project, we propose to advance our understanding of protective and risk factors for late-life cognitive decline and Alzheimer's disease and Alzheimer’s disease-related dementias by taking advantage of new harmonized data from the HRS family of surveys across 33 countries. We propose a novel life-course model of risk factors, building on the recently proposed model by the Lancet commission, which links the risk of Alzheimer's disease and Alzheimer’s disease-related dementia to early and mid-life factors, within the context of historical, institutional, and physical environments. This proposal seeks to explore how psychological well-being and the risk of Alzheimer's disease and Alzheimer’s disease-related dementias evolve later in life and how these are affected by major life changes, such as retirement, and changes in family circumstances (for instance death or major health events of a spouse). In doing so, we place special emphasis on the role of early life conditions, both as determinants of observed cognition and psychological wellbeing and as moderating factors in the explanation of the effects of major life changes later in life. We will be analyzing rich and comparable data from 31 countries, by taking advantage of the fact that a number of the main aging studies in the Western world (Health and Retirement Study, HRS; English Longitudinal Study of Aging, ELSA; Survey of Health, Ageing and Retirement in Europe, SHARE) have recently included (or are about to include) life history modules eliciting information about childhood health, family circumstances, education, and residential mobility. In addition to these self-reports we will make use of contextual and institutional information, both at present and at the time of a respondent’s childhood (such as the state of the business cycle or infant mortality). The contextual information will help in identifying causal effects of circumstances and events during a respondent’s childhood and adult life on later life cognitive function and risk of Alzheimer's disease and Alzheimer’s disease-related dementias, and psychological well-being.

预期寿命的提高正在促进老年人口的大小迅速增加，并有望导致痴呆症病例急剧上升，从当今全球的约4700万人到2050年的可能超过1.4亿人。在该项目中，我们建议促进我们对延迟的认知能力和艾尔兹（Alzheimer）病的远处依赖的生命范围，并促进我们对新的危险因素的理解，而艾尔兹（Alzheimer）的疾病依风使我们的病态依靠众人的疾病范围偏见，而艾尔兹（Alzheimer）的疾病则依靠众人的疾病，而艾尔兹（Alzheimer）的疾病依然依然依然依恋的境地则是众多的疾病。在33个国家 /地区的HRS家族调查家族。我们提出了一种新型的危险因素生活课程模型，这是基于柳叶刀委员会最近提出的模型的基础，该模型将阿尔茨海默氏病和阿尔茨海默氏病与疾病相关的痴呆症与早期和中期因素联系起来，并在历史，机构和身体环境的背景下。 该提案旨在探讨心理健康和阿尔茨海默氏病的风险以及阿尔茨海默氏病与疾病相关的痴呆症在生活后期进化，以及它们如何受到重大生活变化的影响，例如退休和家庭环境的变化（例如，死亡或配偶的重大健康事件）。在此过程中，我们特别强调了早期生活条件的作用，既是观察到的认知和心理健康的坚定因素，又是调节因素，解释了以后生活中主要生活变化的影响。 我们将通过利用以下事实来分析来自31个国家 /地区的丰富数据，即西方世界中的许多主要衰老研究（健康和退休研究，人力资源管理；英语对衰老，ELSA，ELSA的纵向研究；欧洲的衰老和退休调查，欧洲的衰老和退休，分享，分享）最近包括（或包括）（或包括在内）的生活模块化对儿童健康的态度和家庭态度，并习惯了家庭的生活。除这些自我报告外，我们还将利用当前和受访者童年时（例如商业周期或婴儿死亡率）的上下文和机构信息。上下文信息将有助于确定受访者童年和成人生活期间环境和事件对以后生活认知功能以及阿尔茨海默氏病的风险以及与阿尔茨海默氏病有关的痴呆症的风险以及心理健康的风险。