Brain Healthy Soul Food Diet Intervention Among Older African Americans

老年非洲裔美国人大脑健康灵魂食物饮食干预

• 批准号: 10192195
• 负责人: Ashley Richelle Shaw
• 金额: $ 12.85万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10192195
• 关键词: Address; Adherence; Adult; Affect; African American; Alzheimer' s Disease; Alzheimer' s disease risk; Area; Attitude; Behavior; Behavioral; Biological Markers; Blood Pressure; Body Composition; Body fat; Brain; Burn injury; Caucasians; Cause of Death; Cholesterol; Chronic; Clinical Trials Design; Cognition; Cognitive; Communities; Consumption; Crystallization; DASH diet; Data; Development; Diabetes Mellitus; Diet; Dietary Intervention; Dietary Practices; Disease; Environment; Evaluation; Focus Groups; Food; Food Preferences; Geographic Locations; Goals; Health Status; High Prevalence; Impaired cognition; Intervention; Knowledge; Life Style; Mediterranean Diet; Mentored Research Scientist Development Award; Mentors; Mentorship; Nerve Degeneration; Not Hispanic or Latino; Nutritional; Obesity; Outcome; Participant; Pilot Projects; Play; Prevention strategy; Public Health; Recommendation; Reporting; Research; Research Design; Research Methodology; Research Personnel; Resources; Risk; Risk Factors; Role; Surveys; Testing; Time; Training; Work; acceptability and feasibility; age related; base; brain health; cardiovascular risk factor; career development; cognitive function; cognitive testing; community based research; cultural values; design; dietary; dietary adherence; effective intervention; efficacy testing; ethnic minority population; experience; good diet; improved; lifestyle intervention; modifiable risk; nutrition education; personalized approach; prevent; racial and ethnic; therapy design; therapy development

PROJECT SUMMARY AD is the 4th leading cause of death among African Americans and African Americans are two to three times more likely to develop AD compared to non-Hispanic Caucasians. Given the high prevalence of diabetes and obesity and the emerging evidence that up to 50% of AD cases are a result of modifiable risk factors, prevention strategies may play a critical role in reducing AD risk for AAs. Previous research has indicated that adherence to healthy diets such as the Mediterranean diet, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurogenerative Delay (MIND) help slow cognitive decline among adults 65 years and older. However, adherence and acceptability of such diets remain low among African Americans, due to lack of cultural considerations. Thus, there is a critical need for the development of a culturally adapt brain healthy diet that is congruent with African American cultural values and food preferences. Creating a culturally relevant brain healthy diet for African Americans, will enhance both acceptability and adherence which are essential to lifestyle behavioral changes. The proposed project aligns well with the NIA Strategic Directions for Research Goal C-3: Develop interventions for treating, preventing, or mitigating the impact of age-related diseases and condition; by meaningfully incorporating a culturally tailored approach to an adapted diet intervention to reduce the risk of cardiovascular risk factors related to AD and to maintain independence among older African Americans. Specifically, Dr. Shaw plans to address the following specific aims (1) develop an adapted brain healthy soul food diet intervention; (2) pilot test an adapted brain- healthy soul food diet intervention; (3) explore the effect of the adapted brain-healthy soul food diet intervention of cognitive function as preliminary data to design a RCT. To achieve these specific aims, Dr. Shaw will work with a highly skilled mentorship team (Drs. Jeffrey Burns, Debra Sullivan, and Janette Berkley-Patton) and consultants (Dr. Crystal Glover and Mr. Broderick Crawford) to build four areas of expertise relevant to the research agenda: (1) ARDR clinical trial design and implementation (2) cultural tailoring of established diets (3) qualitative design and analysis (4) community-based research design. The K01 award will enhance Dr. Shaw's capabilities to successfully transition into an independent researcher who has expertise in the development and evaluation of culturally tailored lifestyle interventions to reduce AD risk among African Americans. Results of the proposed research will enhance our understanding of how AA culture influences current dietary practice, adherence, acceptability, and feasibility of a brain-healthy diet for older AA. Results will also positively impact the development of R01 scale RCT to test the efficacy of an adapted brain-healthy diet intervention among older AA across a larger geographical area.

项目摘要 广告是非洲裔美国人和非裔美国人中的第四个主要死亡原因 与非西班牙裔高加索人相比，更可能发展广告。鉴于糖尿病患病率很高 肥胖和新兴证据表明，多达50％的AD病例是可改变的危险因素的结果， 预防策略可能在降低AAS的AD风险方面起关键作用。以前的研究表明 遵守健康饮食（例如地中海饮食），饮食的方法来阻止高血压（DASH）， 和地中海 - 破坏性干预神经发生延迟（思维）有助于缓慢的认知能力下降 成人65岁以上。但是，这种饮食的依从性和可接受性仍然很低 由于缺乏文化考虑，美国人。因此，迫切需要开发 在文化上适应大脑健康饮食，与非裔美国人的文化价值和食物一致 偏好。为非裔美国人创建具有文化相关的大脑健康饮食，将增强 可接受性和依从性对于生活方式的行为改变至关重要。拟议的项目对齐 与NIA的研究目标C-3的战略方向：制定干预措施以治疗，预防或 减轻与年龄有关的疾病和病情的影响；通过有意义地纳入文化量身定制的 适应饮食干预的方法，以降低与AD相关的心血管危险因素的风险 保持非裔美国人的独立性。特别是，肖博士计划解决以下内容 具体目的（1）发展了适应性的大脑健康的灵魂食物饮食干预； （2）试验测试适应的大脑 - 健康的灵魂食品饮食干预； （3）探索改编自脑健康的灵魂食物饮食干预的效果 认知功能是设计RCT的初步数据。为了实现这些特定目标，肖博士将有效 与高技能的指导团队（Jeffrey Burns博士，Debra Sullivan和Janette Berkley-Patton）和 顾问（Crystal Glover博士和Broderick Crawford先生）建立了与该领域有关的四个专业领域 研究议程：（1）ARDR临床试验设计和实施（2）既定饮食的文化剪裁（3） 定性设计与分析（4）基于社区的研究设计。 K01奖将增强Shaw博士的 成功过渡到具有专业知识的独立研究人员的能力 以及评估文化量身定制的生活方式干预措施，以降低非裔美国人的AD风险。结果 拟议的研究将增强我们对AA文化如何影响当前饮食实践的理解， 对年长的AA的脑部健康饮食的依从性，可接受性和可行性。结果也将对 R01量表RCT的开发以测试适应性脑部健康饮食干预措施的功效 较大的地理区域较大的AA。