Environmental Carcinogenesis and Mutagenesis

环境致癌和突变

• 批准号: 10189584
• 负责人: WILLIAM E MILLER
• 金额: $ 54.87万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10189584
• 关键词: environmental carcinogenesis; environmental mutagens

This application is to renew the T32 ES-09250-30 training grant entitled, “Environmental Carcinogenesis and Mutagenesis” (ECM) which has been under the direction of Dr. Stambrook since its inception in 1986. Dr. Alvaro Puga, the Co-PI, has been a mentor in the Program since early in its history and has served as Associate Director for the past five-year budget period, a role in which he will continue. The ECM training program initially focused exclusively on environmental carcinogenesis and mutagenesis as its title implied. Subsequently, the Program has evolved scientifically and conceptually. It grew to its current optimal size when the NIEHS directed that it merge with a smaller training program in toxicology. The Program became scientifically more diverse which has proven invaluable to the trainees. The ECM program makes every effort to retain this breadth of disciplines to enhance cross-fertilization of ideas and techniques between the trainees. Thus, the trainees are able to discuss cogently the impact of environmental exposures in terms of genetics, cell biology and toxicology and ultimately in the context of human disease, including cancer. To preserve this wide range of disciplines, the Program maintains a participating faculty of 26 who derive from 12 different departments/divisions from the University of Cincinnati College of Medicine (UCCOM) or the Cincinnati Children's Hospital Medical Center (CCHMC). There is a very close working relationship between the faculty of these two institutions, and the CCHMC faculty all have appointments in pediatrics at UCCOM. The financial support committed to the ECM from both institutions for recruitment and for other training-related expenses exemplifies this tight relationship and support for the ECM. The ECM continues to build on its past successes, with its graduates populating academic, regulatory and industry leadership positions. It also continues to fulfill a national need to train individuals in the impact of environmental exposure relating to biological, oncological and toxicological endpoints and human disease. Since its inception, the Program has emphasized recruitment of under-represented minorities, and has been successful in this endeavor. Institutionally, the Program brings together the research efforts of several laboratories to provide a common focus on exposure and environmental health, and facilitates collaborations between these laboratories. The ECM encourages trainees to engage in research that combines the expertise of several laboratories and institutional research cores. Our biweekly meetings where trainees alternatively present their own data or a topical paper reinforce these interactions. Pre-doctoral trainees all have the equivalent of an undergraduate major in a chemical, biological or physical science with superior academic achievements. Many have won awards and recognition while in the Program. We select postdoctoral candidates who hold the degrees of Ph.D., D.V.M. or M.D., based on proven academic accomplishments, and like predoctoral fellows, we select trainees from a national pool of applicants. This renewal application requests eight pre-doctoral and four postdoctoral positions, a size that we find optimal for the mission and goals of this Program.

本申请旨在更新 T32 ES-09250-30 培训补助金，题为“环境致癌和 “诱变”（ECM）自 1986 年成立以来一直在 Stambrook 博士的指导下。 Alvaro 博士 联合 PI 普加 (Puga) 自该计划成立之初起就一直是该计划的导师，并曾担任助理 过去五年预算期的主任，最初他将继续担任 ECM 培训计划的职务。 随后，其隐含标题侧重于环境致癌和诱变。 当 NIEHS 指导时，该计划已在科学和概念上发展到目前的最佳规模。 它与较小的毒理学培训计划合并，该计划在科学上变得更加多样化。 事实证明，ECM 项目对学员来说是无价的。 加强学员之间思想和技术的交叉交流。 令人信服地讨论环境暴露在遗传学、细胞生物学和毒理学方面的影响， 最终在包括癌症在内的人类疾病的背景下。 该计划拥有 26 名参与教师，他们来自 12 个不同的部门/部门 辛辛那提大学医学院 (UCCOM) 或辛辛那提儿童医院医疗中心 （CCHMC）这两个机构的教师之间有着非常密切的工作关系。 CCHMC 教员均在 UCCOM 担任儿科职务。 致力于为 ECM 提供财政支持。 来自两个机构的招聘费用和其他培训相关费用体现了这种紧密的关系 以及对 ECM 的支持 ECM 继续在其过去的成功基础上发展，毕业生人数不断增加。 它还继续满足国家对培训的需求。 与生物、肿瘤学和毒理学终点相关的环境暴露影响中的个人 自启动以来，该计划一直强调招募代表性不足的人员。 少数民族，并在这一努力中取得了成功，该计划汇集了研究成果。 多个实验室共同关注暴露和环境健康，并促进 ECM 鼓励学员参与结合这些实验室之间的研究。 我们每两周举行一次会议，培训学员将获得多个实验室和机构研究核心的专业知识。 或者提供自己的数据或主题论文来加强这些互动。 相当于化学、生物或物理科学本科专业，具有优异的学术水平 许多人在该计划期间获得了奖项和认可。 拥有博士学位、兽医学博士或医学博士学位（基于已证实的学术成就）等 博士前研究员，我们从全国申请人库中选择实习生，此续签申请需要八名。 博士前职位和四个博士后职位，我们认为这个规模最适合该计划的使命和目标。