INTSHA: INTERACTIVE TRANSITION SUPPORT FOR HIV-INFECTED ADOLESCENTS USING SOCIAL MEDIA

INTSHA：使用社交媒体为感染艾滋病毒的青少年提供互动过渡支持

• 批准号: 10189698
• 负责人: Brian C. Zanoni
• 金额: $ 18.94万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-27 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10189698
• 关键词: Address; Adolescence; Adolescent; Adolescent Behavior; Adolescent and Young Adult; Adult; Africa South of the Sahara; Age; Area; Behavior Therapy; Behavioral; Behavioral Research; Belief; Caregivers; Caring; Cause of Death; Cessation of life; Child; Childhood; Clinic; Clinical; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Code; Cohort Studies; Communicable Diseases; Communication; Data; Data Collection; Enrollment; Evaluation; Failure; Feedback; Focus Groups; Foundations; General Hospitals; Goals; HIV; HIV-infected adolescents; Health; Health Personnel; Health Technology; Institutes; Internal Medicine; International; Intervention; Intervention Trial; Interview; Knowledge; Learning; Learning Skill; Massachusetts; Media Intervention; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Modeling; Motivation; National Institute of Mental Health; Outcome; Pediatrics; Persons; Principal Investigator; Provider; Psychologist; Public Health Schools; Qualitative Methods; Qualitative Research; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Readiness; Reading; Research; Research Methodology; Research Personnel; Sampling; Schools; Scientist; Self Efficacy; Social Adjustment; Social Sciences; Social support; South Africa; Support Groups; Surveys; Technology; Testing; Theory of Change; Training; United States National Institutes of Health; Viral; Vulnerable Populations; Work; Youth; acceptability and feasibility; antiretroviral therapy; base; behavioral clinical trial; career; clinical research site; design; emotional factor; experience; follow-up; global health; high risk; improved; innovation; mHealth; mortality; novel strategies; pediatric human immunodeficiency virus infection; peer; peer support; perinatal HIV; primary outcome; psychosocial; scale up; secondary outcome; skills; social; social learning; social media; standard of care; stem; therapy design; tool; uptake; virology; Address; Adolescence; Adolescent; Adolescent Behavior; Adolescent and Young Adult; Adult; Africa South of the Sahara; Age; Area; Behavior Therapy; Behavioral; Behavioral Research; Belief; Caregivers; Caring; Cause of Death; Cessation of life; Child; Childhood; Clinic; Clinical; Clinical Trials; Clinical Trials Design; Clinical Trials Network; Code; Cohort Studies; Communicable Diseases; Communication; Data; Data Collection; Enrollment; Evaluation; Failure; Feedback; Focus Groups; Foundations; General Hospitals; Goals; HIV; HIV-infected adolescents; Health; Health Personnel; Health Technology; Institutes; Internal Medicine; International; Intervention; Intervention Trial; Interview; Knowledge; Learning; Learning Skill; Massachusetts; Media Intervention; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Modeling; Motivation; National Institute of Mental Health; Outcome; Pediatrics; Persons; Principal Investigator; Provider; Psychologist; Public Health Schools; Qualitative Methods; Qualitative Research; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Readiness; Reading; Research; Research Methodology; Research Personnel; Sampling; Schools; Scientist; Self Efficacy; Social Adjustment; Social Sciences; Social support; South Africa; Support Groups; Surveys; Technology; Testing; Theory of Change; Training; United States National Institutes of Health; Viral; Vulnerable Populations; Work; Youth; acceptability and feasibility; antiretroviral therapy; base; behavioral clinical trial; career; clinical research site; design; emotional factor; experience; follow-up; global health; high risk; improved; innovation; mHealth; mortality; novel strategies; pediatric human immunodeficiency virus infection; peer; peer support; perinatal HIV; primary outcome; psychosocial; scale up; secondary outcome; skills; social; social learning; social media; standard of care; stem; therapy design; tool; uptake; virology

Significance: South Africa has the highest burden of adolescents living with HIV in the world. Clinical outcomes are poor for adolescents during the transition period. Social media is popular among youth and has potential to improve the modifiable factors in the Social-ecological Model of Adolescent and Young Adult Readiness to Transition (SMART) model such as knowledge, self-efficacy, beliefs, maturity, goals, relationships, peer and social support. The SMART model highlights these modifiable targets of intervention and presents an ideal basis for a behavioral intervention using social media to improve transition care. Innovation: This study will iteratively develop a social media behavioral intervention for adolescents living with HIV and transitioning to adult care in South Africa. This proposal is the first intervention, to our knowledge, designed to address transition outcomes (i.e., retention in care and viral suppression) for HIV-infected adolescents in sub-Saharan Africa where 90% of the pediatric HIV-infections exist. Hypothesis: I hypothesize that an iteratively developed social media based behavioral intervention will be acceptable and feasible for adolescents living with HIV and transitioning to adult care. Approach: I will use in-depth qualitative interviews to determine how social media can overcome barriers and enhance facilitators of successful transition to adult care for adolescents living with HIV in South Africa (Aim 1). I will then iteratively adapt the social media based behavioral intervention, Interactive Transition Support for HIV-infected Adolescents (InTSHA; meaning youth in Zulu), using focus groups with adolescents, their caregivers, and healthcare providers (Aim 2). I will then conduct a pilot clinical trial of the intervention (Aim 3) to determine its acceptability and feasibility. Training Aims: I will undergo didactic study with coursework from the Harvard TH Chan School of Public Health, Harvard Kennedy School, Massachusetts Institute of Technology, and the NIH Office of Social Science and Behavioral Research in: Qualitative research methods for behavioral intervention design, social media use for behavioral interventions, and clinical trials of behavioral interventions. In addition, I will have didactic training with my mentors, attend and present at regular research seminars at Massachusetts General Hospital, conduct formative readings, and participate in the Adolescent Clinical Trials Network (ATN) social media study, iTech. Investigator: Brian Zanoni trained in Internal Medicine/Pediatrics with specialization in Infectious Disease, has extensive clinical experience in adolescent HIV care in South Africa, a strong research foundation, and ample mentorship. Mentors: Jessica Haberer is an expert in global health technology for HIV and serves as Dr. Zanoni’s primary mentor. Christina Psaros is a behavioral scientist and clinical psychologist with expertise in using qualitative research methods for psychosocial aspects of HIV care. Richard Holden is an expert in mobile health technology and behavioral interventions. Kenneth Mayer is an internationally recognized leader in HIV interventions, clinical trials and site principal investigator for the ATN.

意义：南非是世界上艾滋病毒的青少年燃烧最高的。临床 在过渡期间，青少年的结果很差。社交媒体在青年中很受欢迎，并且 在青少年和年轻人的社会生态模型中改善可修改因素的潜力 准备过渡（智能）模型，例如知识，自我效能感，信念，成熟度，目标， 人际关系，同伴和社会支持。智能模型强调了这些可修改的干预目标 并为使用社交媒体改善过渡护理的行为干预提供了理想的基础。 创新：这项研究将为与之相伴的青少年迭代地开发社交媒体行为干预 艾滋病毒并过渡到南非成人护理。据我们所知，该建议是第一次干预 旨在解决艾滋病毒感染的过渡结果（即保留护理和病毒抑制） 撒哈拉以南非洲的青少年存在90％的儿科HIV感染。假设：我假设 迭代开发的基于社交媒体的行为干预将是可以接受的，并且可行 患有艾滋病毒的青少年并过渡到成人护理。方法：我将使用深入的定性访谈 确定社交媒体如何克服障碍并增强成功过渡到成人的促进者 照顾南非艾滋病毒的青少年（目标1）。然后我会迭代地调整基于社交媒体的 行为干预，对感染HIV的青少年的互动过渡支持（INTSHA；意思是青年 Zulu），使用焦点小组与青少年，护理人员和医疗保健提供者（AIM 2）。然后我会 对干预措施进行试验临床试验（AIM 3），以确定其可接受性和可行性。训练 目的：我将在哈佛大学公共卫生学院的课程中进行教学研究， 哈佛大学肯尼迪学校，马萨诸塞州理工学院，NIH社会科学办公室 行为研究：行为干预设计的定性研究方法，社交媒体使用 行为干预和行为干预的临床试验。此外，我还将进行教学培训 与我的导师一起，在马萨诸塞州综合医院的常规研究下水道参加并出席了行为 ITECH的形成性阅读和参加青少年临床试验网络（ATN）社交媒体研究。 研究人员：接受过内科/儿科培训的布莱恩·扎诺尼（Brian Zanoni 南非青少年艾滋病毒护理的丰富临床经验，强大的研究基金会和充足 导师：杰西卡·哈伯勒（Jessica Haberer）是艾滋病毒全球卫生技术的专家，并担任博士。 Zanoni的主要导师。克里斯蒂娜·普萨罗斯（Christina Psaros）是一位行为科学家和临床心理学家 使用定性研究方法，用于艾滋病毒护理的社会心理方面。理查德·霍顿（Richard Holden）是手机的专家 卫生技术和行为干预。肯尼斯·梅耶（Kenneth Mayer）是艾滋病毒的国际认可领导人 ATN的干预措施，临床试验和现场主要研究者。