Project 3 - Development and Field Application of Novel Ultrasensitive Devices for the Measurement of Airborne VOCs

项目3——新型超灵敏空气VOC测量装置的开发及现场应用

• 批准号: 10354691
• 负责人: Michael H Nantz
• 金额: $ 37.21万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10354691
• 关键词: Acrolein; Address; Air; Automobile Driving; Benzene; Cardiometabolic Disease; Chemistry; Clinical Research; Collection; Complex; Coupled; Custom; Data; Detection; Development; Devices; Electrodes; Environmental Exposure; Exhibits; Exposure to; Funding; Future; Gases; Goals; Gold; Home; Hour; In Situ; Indoor environment; Industrialization; Infiltration; Investigation; Mass Fragmentography; Measurement; Measures; Modeling; Modification; Monitor; Participant; Pattern; Process; Protons; Reaction; Research; Residual state; Resolution; Sampling; Signal Transduction; Site; Small-Area Variations; Source; Sulfhydryl Compounds; Superfund; Surface; System; Technology; Temperature; Testing; Time; Toluene; Trichloroethylene; Universities; Work; Xylene; base; cost; design; ethylbenzene; exposed human population; flexibility; gas analyzer; innovation; insight; instrument; mass spectrometer; metal oxide; miniaturize; nanoGold; new technology; novel; programs; remediation; residence; sensor; spatiotemporal; superfund chemical; superfund site; time use; tool; urban setting; vapor intrusion; volatile organic compound; Acrolein; Address; Air; Automobile Driving; Benzene; Cardiometabolic Disease; Chemistry; Clinical Research; Collection; Complex; Coupled; Custom; Data; Detection; Development; Devices; Electrodes; Environmental Exposure; Exhibits; Exposure to; Funding; Future; Gases; Goals; Gold; Home; Hour; In Situ; Indoor environment; Industrialization; Infiltration; Investigation; Mass Fragmentography; Measurement; Measures; Modeling; Modification; Monitor; Participant; Pattern; Process; Protons; Reaction; Research; Residual state; Resolution; Sampling; Signal Transduction; Site; Small-Area Variations; Source; Sulfhydryl Compounds; Superfund; Surface; System; Technology; Temperature; Testing; Time; Toluene; Trichloroethylene; Universities; Work; Xylene; base; cost; design; ethylbenzene; exposed human population; flexibility; gas analyzer; innovation; insight; instrument; mass spectrometer; metal oxide; miniaturize; nanoGold; new technology; novel; programs; remediation; residence; sensor; spatiotemporal; superfund chemical; superfund site; time use; tool; urban setting; vapor intrusion; volatile organic compound

PROJECT SUMMARY (Project 3) This proposed work is to advance airborne volatile organic compound (VOC) detection and quantification technologies, and to robustly characterize indoor/outdoor contrast and in-home determinants for exposures to target Superfund-relevant VOCs. This research will continue to grow and expand two VOC real-time in situ measurement platforms developed by the University of Louisville Superfund Research Center established in 2017. One platform comprises small, low-cost sensors that can be deployed alone or in networks. Novel gas sensors and sensor arrays are being developed to measure target Superfund-relevant VOCs including acrolein, trichloroethene (TCE), benzene, toluene, ethylbenzene, and xylene (BTEX). The devices use novel surface chemistries to address the common challenges of selectivity and sensitivity and are fabricated using microelectromechanical systems (MEMS) technology. Another platform addresses the need for flexibly designed, field-deployable instruments that can measure with high sensitivity a large range of compounds to interrogate microenvironments with complex VOC mixtures. The Multichannel Organics In-situ enviRonmental Analyzer (MOIRA) instrument, developed in the first cycle of Center funding for mobile monitoring, will be expanded and optimized for indoor/outdoor VOC monitoring studies. MOIRA is a gas chromatography–mass spectrometry (GC-MS) instrument with high time resolution (e.g., ten minutes). Its capabilities will be expanded to measure both higher and lower volatility compounds than can be achieved with the current design. These innovative, high time resolution in situ measurements will be coupled with conventional time-integrated VOC passive sampling to measure target Superfund-relevant VOCs at homes of some participants in the allied clinical study. These data will be used to build spatiotemporal models to estimate ambient VOCs at the homes of all clinical study participants, and to gain new insights into VOC levels and their determinants in the home microenvironment. In addition to exposure assessment, the two measurement platforms are responsive to ongoing Superfund program advancements; these innovative developments will expand future capacities to monitor VOC indoor vapor intrusion, monitor outdoor VOC levels during site remediation, and monitor both indoors and outdoors during post-remediation surveillance.

项目摘要（项目3） 这项提出的工作是推进空气传播的挥发性有机化合物（VOC）检测和定量 技术，并牢固地表征室内/室外对比度，并在家中确定暴露于 针对与超级基金相关的VOC。这项研究将继续增长和扩展两个实时的两个VOC实时 路易斯维尔大学超级基金研究中心开发的测量平台成立于 2017年。一个平台包括可以单独或网络中部署的小型低成本传感器。新型气体 正在开发传感器和传感器阵列，以测量目标超级基金相关的VOC，包括丙烯醛， 三氯乙烯（TCE），苯，甲苯，乙烯苯和二甲苯（BTEX）。设备使用新颖的表面 化学以应对选择性和灵敏度的共同挑战，并使用 微电动系统（MEMS）技术。另一个平台解决了灵活的需求 设计的，可采用的仪器可以高灵敏度测量各种化合物 用复杂的VOC混合物来询问微环境。多通道有机物原位环境 分析仪（Moira）仪器是在移动监控中心资助的第一个周期中开发的，将是 扩展和优化用于室内/室外VOC监测研究。 Moira是气相色谱 - 质量 具有较高时间分辨率的光谱法（GC-MS）仪器（例如，十分钟）。它的功能将扩大 与当前设计相比，要测量更高和较低的波动率化合物。这些 创新的高时间分辨率原位测量将与常规的时间集成VOC相结合 被动抽样以测量与盟军临床某些参与者的家中的目标超级基金相关的VOC 学习。这些数据将用于构建时空模型，以估计所有人的房屋中的环境VOC 临床研究参与者，并在家中获得对VOC级别及其决定者的新见解 微环境。除了接触评估外，两个测量平台还响应 持续的超级基金计划进步；这些创新的发展将使未来能力扩大到 监视VOC室内蒸气入侵，在现场修复过程中监视室外VOC水平，并监视两者 室内和室外进行修复后监视。