Development of Novel Ultrasensitive Devices for the Measurement of VOCs

开发用于测量 VOC 的新型超灵敏设备

• 批准号: 9260446
• 负责人: Michael H Nantz
• 金额: $ 17.77万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9260446
• 关键词: 1,3-Butadiene; Acrolein; Acute; Adsorption; Air; Benzene; Biomedical Research; Butadiene; Chemicals; Chronic; Complex; Coupled; Custom; Detection; Development; Devices; Disease; Ecology; Electrodes; Engineering; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Exposure to; Face; Gas Chromatography; Gases; Goals; Gold; Health; High Pressure Liquid Chromatography; Human; Insulin Resistance; Ions; Liquid substance; Mass Spectrum Analysis; Measurement; Measures; Methods; Modification; Normal Range; Oxidants; Pattern; Process; Research; Research Project Grants; Security; Signal Transduction; Silicon; Site; Sulfhydryl Compounds; Superfund; Surface; System; Techniques; Technology; Temperature; Tube; Vinyl Chloride; Work; adduct; air sampling; base; carbonyl compound; cost; design; functional group; glycolaldehyde; improved; mass spectrometer; metal oxide; microsensor; miniaturize; nanoparticle; new technology; novel; sensor; simulation; superfund site; vascular inflammation; volatile organic compound; 1,3-Butadiene; Acrolein; Acute; Adsorption; Air; Benzene; Biomedical Research; Butadiene; Chemicals; Chronic; Complex; Coupled; Custom; Detection; Development; Devices; Disease; Ecology; Electrodes; Engineering; Environmental Exposure; Environmental Monitoring; Environmental Pollutants; Exposure to; Face; Gas Chromatography; Gases; Goals; Gold; Health; High Pressure Liquid Chromatography; Human; Insulin Resistance; Ions; Liquid substance; Mass Spectrum Analysis; Measurement; Measures; Methods; Modification; Normal Range; Oxidants; Pattern; Process; Research; Research Project Grants; Security; Signal Transduction; Silicon; Site; Sulfhydryl Compounds; Superfund; Surface; System; Techniques; Technology; Temperature; Tube; Vinyl Chloride; Work; adduct; air sampling; base; carbonyl compound; cost; design; functional group; glycolaldehyde; improved; mass spectrometer; metal oxide; microsensor; miniaturize; nanoparticle; new technology; novel; sensor; simulation; superfund site; vascular inflammation; volatile organic compound

Hazardous volatile organic compounds (VOCs) in environmental air have both acute and chronic effects on human health. Gas chromatography coupled with a mass spectrometer (GC- MS) is the most common technology used for analysis of airborne VOCs. However, GC-MS is not effective for on-site measurement of trace VOCs at Superfund sites. The overall goal of this environmental science research project is to develop novel technologies for quantitative analysis of trace VOCs in both the lab and for on-site measurement of toxic, airborne VOCs. We will focus on measurements of acrolein, vinyl chloride, benzene and 1,3-butadiene. The approach is to investigate chemoselective microreactors for capture of Superfund VOCs. Microreactors provide superior advantages of miniaturized device size, very low cost, and fast detection over current sorbent-based tube preconcentrators. We also will develop thiol-modified gold nanoparticle gas sensor arrays for on-site detection of these VOCs. Functionalized thiols will be synthesized to detect target VOCs at a concentration range from sub-ppb to a few ppm. The thiols proposed for modification of gold nanoparticles will have functional groups and structural motifs to specifically promote interaction with and recognition of target VOCs, thus significantly increasing sensing selectivity and sensitivity. The sensors will work at ambient temperature. This research project will lead to transformational technologies for quantitative analysis of trace VOCs. The research is directly related to the overall goals of the Center for investigating the effects of exposure to VOCs on inducing/exacerbating cardiometabolic disease. The project will also have significant broader impacts on monitoring environmental air and on promoting homeland security.

环境空气中的有害挥发性有机化合物（VOC）均具有急性和 慢性对人类健康的影响。气相色谱与质谱仪结合（GC-） MS）是用于分析机载VOC的最常见技术。但是，GC-MS是 对于超级基金站点的痕量VOC的现场测量无效。总体目标 环境科学研究项目是为定量的新技术开发 分析实验室和现场测量有毒的空中VOC中的痕量VOC。 我们将专注于测量丙烯醛，氯化乙烯，苯和1,3-丁二烯。这 方法是研究用于捕获超级基金VOC的化学选择性微反应器。 微反应器可提供小型设备尺寸，成本非常低的优势，快速 对当前基于吸附剂的管子预浓缩剂的检测。我们还将开发硫醇修饰 金纳米颗粒气体传感器阵列，用于现场检测这些VOC。功能化的硫醇 将合成以检测浓度范围从子ppb到少数ppm的目标VOC。 提出的用于修饰金纳米颗粒的硫醇将具有功能组，并且 结构基序以特异性促进与目标VOC的相互作用和识别，从而 显着提高感应性选择性和灵敏度。传感器将在环境中工作 温度。该研究项目将导致用于定量的变革技术 痕量VOC的分析。该研究与中心的整体目标直接相关 调查接触VOC的影响对诱导/恶化心脏代谢的影响 疾病。该项目还将对监视环境空气产生更广泛的影响 并促进国土安全。