Evaluating teeth as fossil records of children's prenatal/perinatal trauma exposure and future mental health risk

评估牙齿作为儿童产前/围产期创伤暴露和未来心理健康风险的化石记录

• 批准号: 10354569
• 负责人: Erin Cathleen Dunn
• 金额: $ 28.84万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10354569
• 关键词: Affect; Age; Anthropology; Anxiety; Archaeology; Biological; Biological Markers; Boston; Brain; Breast Feeding; Calendar; Child; Confocal Microscopy; Data; Data Analyses; Dental Enamel; Dentin; Development; Distress; Electronic Health Record; Event; Exposure to; Fetal Development; Fossils; Funding; Future; Growth; Health; Histology; Image; Interruption; Knowledge; Lasers; Life; Life Cycle Stages; Light; Link; Measurement; Measures; Mental Depression; Mental Health; Mental disorders; Methods; Moods; Mothers; Natural experiment; Newborn Infant; Pathway interactions; Patient Self-Report; Pattern; Perinatal; Physiological; Population; Pregnancy; Process; Psyche structure; Psychological Stress; Psychopathology; Psychosocial Stress; Recording of previous events; Records; Research; Risk; School-Age Population; Second Pregnancy Trimester; Severities; Shapes; Stress; Stressful Event; Symptoms; Techniques; Testing; Third Pregnancy Trimester; Time; Tooth structure; Trauma; Trees; Width; Woman; Work; base; biobank; cytokine; deciduous tooth; early detection biomarkers; early life stress; experience; in utero; insight; lifestyle factors; light microscopy; maternal stress; microCT; mineralization; molecular marker; neuropsychiatry; novel strategies; offspring; perinatal period; physical conditioning; pilot test; pregnant; prenatal; prepregnancy; psychological stressor; psychosocial; psychosocial stressors; repository; response; stressor; tool; trauma exposure; traumatic event

According to the “prenatal programming of mental illness” hypothesis, the prenatal period is one of the earliest sensitive periods in development when maternal psychosocial stress exposure can have enduring effects on offspring mental health. Currently, many measurement tools exist to characterize the occurrence of maternal psychosocial stress exposure (e.g., depression; anxiety, stressful life events, etc). However, these measures may not fully record the presence and timing of these experiences, especially when administered to mothers retrospectively. To better assess the biological consequences of maternal psychosocial stressors on children, objective tools are additionally needed to capture the prenatal and perinatal presence and timing of maternal stressful life experiences. With a broader array of available tools, our field will be better poised to identify children who are most vulnerable and intervene. Our group has been exploring children’s shed primary teeth as objective and non-invasive tools that record the occurrence and timing of pre- and perinatal stressful life events. Since teeth provide a fossilized record of their formation process, our working hypothesis is that early life stressors– and particularly the timing of these psychosocial events – can be non-invasively measured in shed teeth that began forming in utero. In this R21, we will test this hypothesis across two aims by analyzing data collected from a separately-funded study called STRONG (Stories Teeth Record of Newborn Growth). STRONG was funded in 2019 to build a biorepository of teeth from children whose mothers were exposed to the 2013 Boston Marathon Bombing and manhunt events. In Aim 1, we will use techniques standardly deployed in anthropology/archaeology (e.g., microCT imaging; histology; light microscopy) alongside newer approaches (e.g., laser confocal microscopy) to derive a stress and other markers in teeth and determine the parameters for when and how the Marathon bombing is visible in shed teeth. In Aim 2, we will pair these tooth- based measures with subjective (self-report and electronic-health records) data of the bombing exposure to compare the strength of the association between these two sets of measures on levels of child psychopathology symptoms. As far as we know, this study would be the first to determine the degree to which primary teeth mark the presence and timing of maternal psychological stress in relation to a traumatic event. If validated as biomarkers, teeth would transform the study of sensitive periods by providing a new, non-invasive measure for capturing and dating pre- and perinatal psychosocial exposures. Teeth could be used alongside existing tools to screen children for early life stress exposure and to understand its biological consequences.

根据“精神疾病的产前编程”假设，产前时期是最早的时期之一 当孕产妇的社会心理压力暴露可能对 后代心理健康。当前，存在许多测量工具来表征孕产妇的发生 社会心理压力暴露（例如，抑郁；焦虑，压力性生活事件等）。但是，这些措施 可能无法完全记录这些经历的存在和时机，尤其是在给母亲管理时 追溯。为了更好地评估孕产妇的社会心理压力源对儿童的生物学后果， 还需要客观的工具来捕获产前和围产期的存在和孕产妇的时机 压力生活经历。有了更广泛的可用工具，我们的领域将被更好地中毒以识别 最脆弱和干预的孩子。我们的小组一直在探索儿童棚的初级牙齿 作为记录前和围产期压力生活的出现和时机的客观和非侵入性工具 事件。由于牙齿提供了形成过程的化石记录，因此我们的工作假设是 生命压力源，尤其是这些社会心理事件的时机 - 可以无创测量 在子宫内开始形成的牙齿。在此R21中，我们将通过分析两个目标检验这一假设 从单独资助的研究中收集的数据，称为Strong（新生儿生长的牙齿记录）。 Strong于2019年获得资助，以建造一个牙齿的生物牙齿，从母亲接触过的孩子 2013年波士顿马拉松爆炸和搜捕活动。在AIM 1中，我们将标准使用技术 部署在人类学/考古学（例如Microct成像；组织学；光学显微镜）中 方法（例如，激光共聚焦显微镜）来推导牙齿中的应力和其他标记，并确定 何时以及如何在牙齿中可见马拉松轰炸的参数。在AIM 2中，我们将配对这些牙齿 - 具有主观的措施（自我报告和电子保健记录）数据的数据 比较这两组儿童水平的措施之间的关联强度 精神病理学症状。据我们所知，这项研究将是第一个确定程度的研究 初级牙齿标志着与创伤事件有关的孕产妇心理压力的存在和时间。如果 牙齿被证明为生物标志物，通过提供一种新的无侵入性来改变敏感时期的研究 捕获和约会前和围产期社会心理暴露的措施。牙齿可以与 现有的工具筛查儿童以早期生活压力暴露并了解其生物学后果。