Evaluating teeth as fossil records of children's prenatal/perinatal trauma exposure and future mental health risk

评估牙齿作为儿童产前/围产期创伤暴露和未来心理健康风险的化石记录

基本信息

批准号：
10354569
负责人：
Erin Cathleen Dunn
金额：
$ 28.84万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-01 至 2024-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10354569
关键词：
Affect Age Anthropology Anxiety Archaeology Biological Biological Markers Boston Brain Breast Feeding Calendar Child Confocal Microscopy Data Data Analyses Dental Enamel Dentin Development Distress Electronic Health Record Event Exposure to Fetal Development Fossils Funding Future Growth Health Histology Image Interruption Knowledge Lasers Life Life Cycle Stages Light Link Measurement Measures Mental Depression Mental Health Mental disorders Methods Moods Mothers Natural experiment Newborn Infant Pathway interactions Patient Self-Report Pattern Perinatal Physiological Population Pregnancy Process Psyche structure Psychological Stress Psychopathology Psychosocial Stress Recording of previous events Records Research Risk School-Age Population Second Pregnancy Trimester Severities Shapes Stress Stressful Event Symptoms Techniques Testing Third Pregnancy Trimester Time Tooth structure Trauma Trees Width Woman Work base biobank cytokine deciduous tooth early detection biomarkers early life stress experience in utero insight lifestyle factors light microscopy maternal stress microCT mineralization molecular marker neuropsychiatry novel strategies offspring perinatal period physical conditioning pilot test pregnant prenatal prepregnancy psychological stressor psychosocial psychosocial stressors repository response stressor tool trauma exposure traumatic event

项目摘要

According to the “prenatal programming of mental illness” hypothesis, the prenatal period is one of the earliest sensitive periods in development when maternal psychosocial stress exposure can have enduring effects on offspring mental health. Currently, many measurement tools exist to characterize the occurrence of maternal psychosocial stress exposure (e.g., depression; anxiety, stressful life events, etc). However, these measures may not fully record the presence and timing of these experiences, especially when administered to mothers retrospectively. To better assess the biological consequences of maternal psychosocial stressors on children, objective tools are additionally needed to capture the prenatal and perinatal presence and timing of maternal stressful life experiences. With a broader array of available tools, our field will be better poised to identify children who are most vulnerable and intervene. Our group has been exploring children’s shed primary teeth as objective and non-invasive tools that record the occurrence and timing of pre- and perinatal stressful life events. Since teeth provide a fossilized record of their formation process, our working hypothesis is that early life stressors– and particularly the timing of these psychosocial events – can be non-invasively measured in shed teeth that began forming in utero. In this R21, we will test this hypothesis across two aims by analyzing data collected from a separately-funded study called STRONG (Stories Teeth Record of Newborn Growth). STRONG was funded in 2019 to build a biorepository of teeth from children whose mothers were exposed to the 2013 Boston Marathon Bombing and manhunt events. In Aim 1, we will use techniques standardly deployed in anthropology/archaeology (e.g., microCT imaging; histology; light microscopy) alongside newer approaches (e.g., laser confocal microscopy) to derive a stress and other markers in teeth and determine the parameters for when and how the Marathon bombing is visible in shed teeth. In Aim 2, we will pair these tooth- based measures with subjective (self-report and electronic-health records) data of the bombing exposure to compare the strength of the association between these two sets of measures on levels of child psychopathology symptoms. As far as we know, this study would be the first to determine the degree to which primary teeth mark the presence and timing of maternal psychological stress in relation to a traumatic event. If validated as biomarkers, teeth would transform the study of sensitive periods by providing a new, non-invasive measure for capturing and dating pre- and perinatal psychosocial exposures. Teeth could be used alongside existing tools to screen children for early life stress exposure and to understand its biological consequences.

根据“精神疾病的产前规划”假说，产前期是最早的阶段之一。发育的敏感时期，母亲的社会心理压力暴露会对孩子产生持久的影响目前，存在许多测量工具来表征母亲的心理健康状况。然而，心理社会压力暴露（例如抑郁、焦虑、压力性生活事件等）。可能无法完整记录这些经历的存在和时间，特别是当给予母亲时回顾性地更好地评估母亲社会心理压力源对儿童的生物学影响，此外还需要客观的工具来捕捉产前和围产期的情况以及孕产妇的出现时间。有了更广泛的可用工具，我们的领域将能够更好地识别压力生活经历。我们的小组一直在探索儿童脱落的乳牙。作为记录产前和围产期压力生活的发生和时间的客观和非侵入性工具由于牙齿提供了其形成过程的化石记录，我们的工作假设是早期的。生活压力源，尤其是这些社会心理事件的发生时间，可以通过以下方式进行非侵入性测量：在这个 R21 中，我们将通过分析来测试这个假设的两个目标。数据收集自一项名为 STRONG（新生儿牙齿生长故事记录）的独立资助研究。 STRONG 于 2019 年获得资助，建立了一个生物储存库，储存母亲接触过的儿童的牙齿 2013年波士顿马拉松爆炸和搜捕活动中，我们将标准使用技术。与更新的技术一起部署在人类学/考古学（例如 microCT 成像、组织学、光学显微镜）中方法（例如，激光共焦显微镜）得出牙齿中的应力和其他标记并确定马拉松轰炸何时以及如何在脱落的牙齿中可见的参数在目标 2 中，我们将配对这些牙齿 - 基于爆炸暴露的主观（自我报告和电子健康记录）数据的测量比较这两组措施与儿童水平之间的关联强度据我们所知，这项研究将是第一个确定其程度的研究。乳牙标志着与创伤事件相关的母亲心理压力的存在和时间。作为生物标志物，牙齿将通过提供新的、非侵入性的方法来改变敏感期的研究。可以同时使用牙齿来捕捉和确定产前和围产期心理社会暴露的时间。现有工具可用于筛查儿童早期生活压力暴露并了解其生物学后果。