ICAL: Impact of Cannabinoids Across Lifespan: Pilot Project Core

ICAL：大麻素对整个生命周期的影响：试点项目核心

• 批准号: 10188477
• 负责人: Christine M Gall
• 金额: $ 7.37万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10188477
• 关键词: Adolescence; Adolescent; Anatomy; Architecture; Area; Behavior; Behavioral; Blood specimen; Brain; Cannabinoids; Cannabis; Child; Cognition; Collaborations; Communities; Consultations; Department chair; Doctor of Philosophy; Electrophysiology (science); Enrollment; Ensure; Epigenetic Process; Exposure to; Faculty; Fostering; Funding; Genetic Processes; Individual; Institutes; Leadership; Longevity; Mentors; Mentorship; Mission; Molecular; Molecular Structure; Mus; National Institute of Drug Abuse; Neurobiology; Neurosciences; Pilot Projects; Rattus; Research; Research Personnel; Resources; Sum; Supervision; System; Talents; Testing; Tissue Banks; Training; United States National Institutes of Health; Work; addiction; career development; cognitive development; comparative; design; endogenous cannabinoid system; innovation; member; motivated behavior; professor; programs; recruit; senior faculty; synaptic function; synergism

PROJECT SUMMARY: PILOT CORE The proposed NIDA Center of Excellence, entitled Impact of Cannabinoids Across the Lifespan (ICAL), will test the hypothesis that non-physiological activation of the endocannabinoid system in adolescence – caused by exposure to THC or one of its synthetic mimics – initiates a reprogramming of the genetic and epigenetic processes that govern this system’s molecular structure, neuroanatomical architecture, and synaptic functions, ultimately producing persistent abnormalities in cognition and motivated behavior. To test this hypothesis, ICAL will deploy a vertically integrated strategy combining molecular, neuroanatomical, electrophysiological, and behavioral approaches. ICAL’s scientific and programmatic objectives will yield many opportunities for neuroscience and addiction researchers to explore exciting new avenues of research. ICAL’s Pilot Core is designed to fulfill two major objectives of the Center: (1) to foster innovative research that aligns with the Center’s scientific mission and maximizes use of its research resources; and (2) to provide high-quality career development activities and mentorship for junior investigators and/or investigators new to cannabinoid research. The Pilot Core will achieve these objectives via its annual competition for pilot funding. The Core Director, Christine Gall, PhD, is Professor and Chair of the Department of Anatomy & Neurobiology and Professor of Neurobiology & Behavior at UCI. Dr. Gall will supervise the recruitment of projects and oversee their progress in consultation with the Center director and co-director, the internal Steering Committee (SC) and External Advisory Group (EAG). The Center’s Administrative Core will provide clerical support for this Core. Junior investigators and/or investigators new to the field who receive ICAL pilot funding will be paired with senior faculty members who will provide mentorship during the pilot project funding period and after research is completed. In addition, pilot grantees will have access to the leadership and expertise of the SC and the EAG. The Pilot Core will serve as a conduit for the exploration of new ideas as well as an important venue for mentoring junior investigators and those new to the field. The Core’s leadership will work to ensure that the potential for each individual project and project investigator is fully realized. !

项目摘要：试点核心 拟议的 NIDA 卓越中心，题为大麻素对整个生命周期的影响 (ICAL)， 将检验青春期内源性大麻素系统的非生理激活这一假设 – 由接触 THC 或其合成模拟物之一引起 – 启动基因重新编程 以及控制该系统分子结构、神经解剖结构的表观遗传过程， 和突触功能，最终导致认知和动机持续异常 为了检验这一假设，ICAL 将部署一种结合分子、 神经解剖学、电生理学和行为学方法。 目标将为神经科学和成瘾研究人员提供许多探索令人兴奋的机会 ICAL 的试点核心旨在实现该中心的两个主要目标：(1) 创新性地促进与中心的科学使命相一致的研究，并最大限度地利用其资源 研究资源；(2) 提供高质量的职业发展活动和指导 初级研究人员和/或刚接触大麻素研究的研究人员将实现这些目标。 其核心董事 Christine Gall 博士是通过年度试点资金竞赛实现的目标。 解剖学与神经生物学系教授兼系主任，神经生物学与神经生物学教授 Gall 博士将监督项目的招募并监督其进展。 与中心主任和联合主任、内部指导委员会 (SC) 和外部指导委员会协商 咨询小组 (EAG)。该中心的行政核心将为该核心提供文书支持。 接受 ICAL 试点资助的初级研究人员和/或新进入该领域的研究人员将被配对 与高级教师一起，他们将在试点项目资助期间提供指导，以及 此外，研究完成后，试点受助者将获得领导力和专业知识。 SC 和 EAG 的试点核心也将充当探索新想法的渠道。 作为指导初级研究人员和该领域新人的重要场所。 领导层将努力确保每个项目和项目研究者的潜力得到发挥 完全实现了。 ！