Alcohol Research Training in epigenetics and pathophysiology (ARTEP)

表观遗传学和病理生理学酒精研究培训 (ARTEP)

• 批准号: 10188341
• 负责人: SUBHASH C. PANDEY
• 金额: $ 30.32万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10188341
• 关键词: Epigenetic Process; Functional disorder; Research Training; alcohol research

Abstract: Alcohol use disorder (AUD) is characterized by a pattern of compulsive alcohol drinking or a loss of control over alcohol drinking. The development of addiction involves neurobiological changes in several key brain regions that play a role in the behavioral manifestations of ethanol dependence. Epigenetic regulation (Histone and DNA chemical modifications) of gene expression is an important area in the field of neuroscience that emphasizes the importance of gene interactions with environmental factors. This T32 training grant entitled “Alcohol Research Training in Epigenetics and Pathophysiology” (ARTEP) is developed in order to directly provide training to pre-doctoral (PhD in neuroscience or psychology) and post-doctoral fellows (PhD, MD/PhD graduates) on epigenetic and molecular processes that play a role in the neuroadaptive and behavioral responses to ethanol as well as the pathophysiology of alcoholism. The major objective of this T32 training grant for the NIAAA funded Alcohol Research Center entitled “Center for Alcohol Research in Epigenetics (CARE)” at the University of Illinois at Chicago (UIC) is to provide training to young researchers in the epigenetic basis of alcohol addiction and to develop leading addiction researchers in this emerging field of neuroscience. Besides outstanding training in addiction research, trainees will also receive supplemental targeted training that will include didactic courses, seminars, presentations at national and international scientific meetings, responsible research conduct, research data handling and management as well as manuscript and grant writing. Trainees coming out of ARTEP will become future independent alcohol researchers to promote cutting edge research in epigenetics and neurobiology to better understand the pathophysiology of AUD. The overarching goal of the alcohol research training program is to provide training to young researchers in epigenetic mechanisms of molecular and behavioral phenotypes of AUD. The objectives are: 1) To provide unified training and apply a multidisciplinary approach by involving established investigators as faculty sponsors with expertise in areas of animal models, human research, tissue culture, human post-mortem brain studies, neuroimaging, electrophysiology, psychiatry, anatomy, epigenetics, molecular biology, and bioinformatics to cover a wide range of topics of addiction. 2) To provide resources and a scientifically enriched environment for graduate students and post- doctoral fellows for suitable training in epigenetic studies in alcoholism so these fellows become independent alcohol researchers. 3) To provide administrative and scientific leadership to trainees and develop them to become leading alcohol researchers. 4) To teach trainees how to prepare research grant applications (F or K grant mechanisms), perform independent research and occupy faculty positions at universities. This training program focusing on epigenetics is very unique in alcoholism research and will accelerate the training of the next generation of bright young scientists and clinicians in the field of alcohol research.

抽象的： 酒精使用障碍（AUD）的特征是强迫饮酒或失去控制的模式 喝酒。成瘾的发展涉及几个关键大脑的神经生物学变化 在乙醇依赖的行为表现中发挥作用的地区。表观遗传调节 基因表达的（组蛋白和DNA化学修饰）是现场的重要区域 强调基因相互作用与环境因素的重要性的神经科学。这个T32 培训赠款名为“表观遗传学和病理生理学的酒精研究培训”（ARTEP）是 开发的目的是直接为博士前的培训（神经科学或心理学博士学位）和 博士后研究员（博士，医学博士/博士学位毕业生）在表观遗传和分子过程中发挥作用 对乙醇以及酒精中毒的病理生理学的神经适应性和行为反应。专业 NIAA资助的酒精研究中心的T32培训赠款的目标，名为“酒精中心 伊利诺伊大学芝加哥大学（UIC）的表观遗传学研究（CARE）”是为年轻人提供培训 研究人员以饮酒成瘾的表观遗传基础，并在此发展领先的成瘾研究人员 神经科学的新兴领域。除了成瘾研究的杰出培训外，学员还将获得 补充有针对性的培训，其中包括教学课程，半手，在国家 /地区的演讲 国际科学会议，负责任的研究行为，研究数据处理和管理 以及手稿和赠款写作。从ARTEP出来的学员将成为未来独立的 酒精研究人员促进表观遗传学和神经生物学的尖端研究以更好地了解 AUD的病理生理学。酒精研究培训计划的总体目标是 向年轻研究人员提供分子和行为表观遗传机制的培训 aud的表型。目标是：1）提供统一的培训并应用多学科 涉及成熟的研究人员作为动物领域具有专业知识的教师赞助者的方法 模型，人类研究，组织培养，人类验尸脑研究，神经成像，电生理学， 精神病学，解剖学，表观遗传学，分子生物学和生物信息学，以涵盖广泛的主题 瘾。 2）为研究生和研究生提供资源和科学丰富的环境 博士研究员在酒精中毒的表观研究中进行适当的培训，因此这些研究员变得独立 3）向学员提供行政和科学领导，并将其发展为 成为领先的酒精研究人员。 4）教学员如何准备研究赠款申请（F或 K赠款机制），进行独立的研究并在大学担任教师职位。这 专注于表观遗传学的培训计划在酒精中毒研究中非常独特，将加速培训 在酒精研究领域的下一代年轻的年轻科学家和临床医生中。