Age effects on memory and reward systems in decision making

年龄对决策中的记忆和奖励系统的影响

• 批准号: 10187476
• 负责人: Anne Shively Berry
• 金额: $ 24.86万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10187476
• 关键词: Address; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Behavioral; Binding; Businesses; Caring; Cognition; Cognitive aging; Collaborations; Communities; Complex; Corpus striatum structure; Cues; Decision Making; Decision Support Systems; Deposition; Development; Dopamine; Dopamine Receptor; Elderly; Environment; Face; Family; Fostering; Foundations; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Hippocampus (Brain); Home; Human; Image; Individual Differences; Laboratories; Learning; Link; Maps; Measures; Medial; Mediating; Medical; Memory; Mentors; Methods; Modeling; Neuromodulator; Outcome; Pathology; Pattern; Performance; Personal Satisfaction; Positron-Emission Tomography; Process; Quality of life; Research; Research Activity; Research Personnel; Resources; Retirement; Rewards; Role; Schools; Shapes; Solid; Specificity; System; Task Performances; Technology; Temporal Lobe; Testing; Training; Tyrosine; Ventral Striatum; Work; age effect; age related; base; career; cognitive process; design; dopamine system; experience; financial decision making; hyperphosphorylated tau; imprint; innovation; neurochemistry; neuroeconomics; neuroimaging; novel; pre-clinical; predictive modeling; predictive test; programs; protein aggregation; relating to nervous system; response; skills; support network; tau Proteins; tau aggregation; young adult

Project Summary Aging is accompanied by profound changes in neurochemical systems as well as accumulation of aggregated proteins. To date, the influence of these processes on cognition has been studied in isolation. The proposed research takes novel steps to bridge these fields to develop an integrative model of how changes across multiple neural systems interact to affect high-level decision making in aging. Candidate and career goals: This project will support the candidate’s essential training and development in the field of cognitive aging, with a particular focus on how decline in reward and memory systems interact to contribute to decision making ability. The candidate has a strong track record of research defining the functional mechanisms by which neuromodulators shape cognition. To support the candidate in launching a sustainable, cross-disciplinary independent research program, two expert mentors will provide individualized training. First, the candidate will train in the field of the neuroeconomics and financial decision making, which she will apply to the field of cognitive aging. Second, the candidate will train in PET methods for assessing Alzheimer’s disease pathology and accompanying medial temporal lobe (MTL) memory function in older adults. This novel research program will capitalize on the candidate’s established expertise while developing critical skills to connect two important lines of cognitive aging research. Environment: The exceptional resources and scientific community at Lawrence Berkeley National Laboratory and UC Berkeley Haas School of Business provide and ideal environment to foster the candidate’s development into an innovative and successful independent investigator. The candidate will have access to state-of-the-art human neuroimaging technology and will be supported by a rich institutional culture promoting creative, cross-disciplinary collaborations. Research activity: Aging is accompanied by 1) dysfunction of the dopamine system, which affects the response to rewards in ventral striatum, and 2) aggregation of hyperphosphorylated tau, associated with MTL degeneration and memory disruption. The proposed K99 studies will delineate the independent and interactive roles of these processes in modulating central components of financial decision making: reward learning and memory. These studies will combine PET imaging in healthy older adults, a novel laboratory task designed specifically to probe striatal-MTL interactions, and a validated measure of real-world financial capacity. The proposed R00 studies will pair the laboratory task with functional MRI to define the patterns of activation and network activity between striatum and MTL that underlie age-related disruption in performance and best predict individual differences in real-world financial capacity. Together, these studies will contribute to new models of how cross-system interactions influence high-level cognition in aging while identifying potential targets for remediating decline.

项目摘要 衰老是通过神经化学系统的深刻变化以及聚集的加速来实现的 蛋白质。迄今为止，这些过程对认知的影响已经孤立地研究了。提议 研究采取了新的步骤来桥接这些领域，以开发一个综合模型，说明如何改变 多个神经元系统相互作用以影响衰老中的高级决策。 候选人和职业目标：该项目将支持候选人的基本培训和发展 认知衰老的领域，特别关注奖励和记忆系统如何相互作用 有助于决策能力。候选人在确定的研究方面有很强的记录 神经调节剂塑造认知的功能机制。支持候选人推出 可持续的，跨学科的独立研究计划，两位专家导师将提供个性化的 训练。首先，候选人将在神经经济学和财务决策领域进行培训， 她将申请认知衰老领域。其次，候选人将培训PET方法进行评估 老年人的阿尔茨海默氏病病理学和参与媒体临时叶（MTL）记忆功能 成年人。这个新颖的研究计划将在开发候选人的既定专业知识上利用 连接两条重要的认知衰老研究行的关键技能。 环境：劳伦斯·伯克利国家实验室的非凡资源和科学界 加州大学伯克利分校的商学院提供和理想的环境来培养候选人的 发展成为创新且成功的独立研究者。候选人将可以访问 最先进的人类神经影像技术，并将得到丰富的机构文化的支持 创意，跨学科的合作。 研究活动：衰老是通过1）多巴胺系统功能障碍完成的，这会影响 对腹侧纹状体的奖励的响应，以及2）与MTL相关的高磷酸化tau的聚集 退化和记忆中断。拟议的K99研究将描述独立和互动性 这些过程在调节财务决策的中心组成部分中的作用：奖励学习和 记忆。这些研究将在健康的老年人中结合宠物成像，这是一个新型的实验室任务 专门用于探测纹状体-MTL相互作用，以及对现实世界财务能力的验证。这 拟议的R00研究将将实验室任务与功能性MRI配对，以定义激活和 纹状体和MTL之间的网络活动是与年龄相关的性能中断和最佳预测的基础 现实世界中财务能力的个体差异。这些研究将共同​​有助于 跨系统相互作用如何影响衰老中的高级认知，同时确定潜在目标 补救的下降。