Administrative Core

行政核心

基本信息

批准号：
9983089
负责人：
MARK E. McCourt
金额：
$ 20.39万
依托单位：
NORTH DAKOTA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9983089
关键词：
Address Advisory Committees Amblyopia American Applications Grants Area Attention Automobile Driving Basic Science Behavioral Biological Markers Biomedical Research Centers of Research Excellence Clinical Treatment Cognition Collection Communication Computer software Core Facility Data Decision Making Dementia Development Disease Dyslexia Early Diagnosis Early Intervention Education and Outreach Electroencephalography Electrophysiology (science)Ensure Esthesia Evaluation Faculty FarGo Fee-for-Service Plans Feedback Fees Foundations Funding Funding Agency Future Goals Health Human Instruction Intervention Intervention Studies Knowledge Leadership Maintenance Mentors Mentorship Mission Names Neurosciences North Dakota Parkinson Disease Participant Perception Perceptual Disorders Performance Phase Pilot Projects Procedures Process Publishing Quality of life Recovery Research Research Activity Research Infrastructure Research Personnel Research Proposals Resources Schizophrenia Services South Dakota Structure Students System Talents Technical Expertise Time Training Activity Translational Research Traumatic Brain Injury Visit authority autism spectrum disorder base career development cognitive neuroscience cost density effective therapy effectiveness evaluation experience infrastructure development innovation mild cognitive impairment neuromechanism normal aging novel operation organizational structure outreach programs recruit relating to nervous system research and development response success symposium tenure track visual neuroscience waiver webinar

项目摘要

Basic and translational research into the neural bases of human sensation, perception, attention, and cognition is necessary to lay the foundation for clinical treatments and interventions. Remarkable progress has been made in the discovery of novel behavioral and electrophysiological biomarkers for disorders of perception, attention, cognition, and action. These include schizophrenia, Parkinson's, autism, dementia, mild cognitive impairment, traumatic brain injury, dyslexia, and amblyopia, to name but a few. These, along with normal aging, negatively impact the health and quality of life of a large number of Americans. Discovering biomarkers for such disorders allows early diagnosis and intervention, and translational research may result in the development of novel and effective treatments. Progress in the field as a whole is reflected in the research accomplishments of CVCN researchers in Phases I and II. In Phase III we will continue to contribute to novel discovery in visual and cognitive neuroscience by supporting creative research activity and world-class Core facilities that will potentiate further discovery. The Administrative Core provides the organizational structure to extend into Phase III the research and infrastructure development goals realized in Phases I and II. The Administrative Core will promote the continued success of research addressing the neural mechanisms of human sensation, perception, and cognition, and action, in both normal and disordered states, through: 1) the sustained efficient operation of 3 Scientific/Technical Cores (Technical Services Core; Driving Simulator Core; High-Density EEG/Neurostimulation Core) which provide mission-critical research resources to CVCN faculty and students, and which benefit the scientific activities of a broad array of current and future users on the NDSU campus and beyond; 2) continued support for a successful competitive Pilot Project Program, initiated in Phases I and II, which provides short-term support as well as scientific mentoring and career development services to applicants with promising research proposals; and 3) the development of, and active participation in, two outreach mechanisms (the Inter-COBRE Council and the Scientific Exchange Network) which will serve as conduits for the exchange of scientific and technical expertise and the dissemination of knowledge, research findings, ideas, and best practices, between COBREs with cognate research themes within the state, the region, and the nation. A formal evaluation process involving internal review and external oversight will be implemented to ensure that the various components of the CVCN are well integrated and operate effectively. A plan to ensure the sustained availability of the Scientific/Technical Cores beyond the Phase III funding period is described which combines efficient Core management, a fee-for-service cost recovery mechanism, and the commitment of permanent institutional resources.

对人类感觉，感知，注意力和认知神经基础的基础和翻译研究为临床治疗和干预措施奠定基础是必要的。取得了显着的进步在发现新颖的行为和电生理生物标志物的感知障碍时，注意，认知和行动。其中包括精神分裂症，帕金森氏症，自闭症，痴呆，轻度认知仅举几例障碍，脑损伤，阅读障碍和弱视。这些，正常衰老，对许多美国人的健康和生活质量产生负面影响。发现生物标志物对于此类疾病，可以尽早诊断和干预，转化研究可能会导致开发新颖有效的治疗方法。整个领域的进步在研究中反映了 CVCN研究人员在第I和II阶段的成就。在第三阶段，我们将继续为新颖通过支持创意研究活动和世界一流的核心，在视觉和认知神经科学中发现将增强进一步发现的设施。行政核心为组织结构提供了扩展到第三阶段的研究和基础设施发展目标在第I和II阶段实现。这行政核心将促进研究的持续成功，以解决在正常状态和无序状态下，人类感觉，感知和认知和行动，通过：1） 3个科学/技术核心（技术服务核心；驱动模拟器核心）的持续有效运行；高密度EEG/神经刺激核心），为CVCN教师提供关键任务研究资源和学生，以及在当前和未来的广泛用户的科学活动中受益于 NDSU校园及以后； 2）继续支持成功的竞争试验项目计划在第I和II阶段，它提供了短期支持以及科学指导和职业发展为有希望的研究建议的申请人提供服务； 3）开发和积极参与在两个将服务作为交流科学和技术专长的渠道以及知识的传播，研究发现，思想和最佳实践，在州内具有同源研究主题的共同点之间，该地区和国家。涉及内部审查和外部监督的正式评估过程将是实施以确保CVCN的各个组成部分均已良好整合和有效运行。一个计划确保超过第三阶段资金期之后的科学/技术核心的持续可用性是描述了哪些结合了有效的核心管理，一种支付费用的成本恢复机制和永久机构资源的承诺。