Core 1: Biospecimen and Pathology Core

核心 1：生物样本和病理学核心

基本信息

批准号：
9983044
负责人：
HARRY VINTERS
金额：
$ 17.8万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-11 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9983044
关键词：
Adherent Culture Animal Model Animals Archives Bioinformatics Biology Biometry Blood Brain Neoplasms Cancer Patient Cell Culture Techniques Cells Cerebrospinal Fluid Chromogenic in situ Hybridization Clinical Clinical Trials Clinical/Radiologic Collaborations Collection Consent Data Databases Development Diagnostic Ensure Family Formalin Freezing Glioblastoma Glioma Goals Grant Growth Health Insurance Portability and Accountability Act Histology Hospitals Human Immunohistochemistry Informatics Institutional Review Boards Joints Label Malignant neoplasm of brain Medical Genetics Microdissection Modeling Molecular Molecular Genetics Monitor Paraffin Pathologic Pathology Patients Pharmaceutical Preparations Primary Neoplasm Privacy Publications Recording of previous events Recurrent tumor Reporter Research Research Activity Research Personnel Research Project Grants Research Support Resources Sampling Services Slide Specimen System Temperature Therapeutic Therapeutic Studies Tissue Microarray Tissue Procurements Tissues Translational Research Tumor Burden Tumor Tissue Urine Work Xenograft Model Xenograft procedure biobank cancer cell career collaborative environment comparative cost data management drug discovery experience flexibility genetic information improved in vivo innovation neoplastic cell neuro-oncology neuroimaging neuropathology next generation novel novel therapeutic intervention pre-clinical preservation prognostic programs public repository sample collection success synergism translational diagnostics treatment response tumor tumor xenograft

项目摘要

Core 1: Biospecimen and Pathology Core (BiPC) SUMMARY/ABSTRACT The Biospecimen and Pathology Core (BiPC, Core 1), a biorepository and multi-faceted research resource led by experienced neuropathologists and cell biologists with ongoing active research expertise, will provide critical support for the translational prognostic, diagnostic, and therapeutic studies proposed in the UCLA SPORE in Brain Cancer. Working closely with the Biostatistics, Bioinformatics, and Data Management Core (BBD, Core 3), BiPC will maximize optimal biospecimen collection/storage and efficient disbursement of consented, clinically annotated, and molecularly characterized biospecimens. This Core will support all four SPORE projects with 24/7 tissue procurement, clinical and family history annotation, and molecular characterization of tissues, plus research support in gliomasphere/neurosphere cultures, tissue microarray, and patient-derived orthotopic xenografts (PDOX). The Biospecimen and Pathology Core Co-Directors and Investigators have a long collaboration history with each other and with all the SPORE Project Leaders, as shown in joint publications, grants, and consortia. In addition to an excellent program for the collection, processing, storage, and dissemination of important biospecimens in support of the proposed SPORE research projects, the BiPC agenda goes well beyond these core functions to the innovative development of new scientific approaches for the maximization of rare/sparse specimen collection and the development of new animal models for therapeutic drug discovery. As part of this core, brain cancer cells grown in animals will be specially adapted to have a fluorescent label so that growth or shrinkage of the tumor can be serially followed in vivo when experimental treatments are given to the animals. The BiPC will develop and provide these materials, resources, and information to SPORE investigators and others, both inside and outside of UCLA. An outstanding team of experienced, accomplished, determined, and productive investigators has been assembled for this Biospecimen and Pathology Core. It also has strong institutional commitment in an excellent collaborative environment, which will help to ensure the success of the overall goals of this SPORE proposal.

核心 1：生物样本和病理学核心 (BiPC) 摘要/摘要生物样本和病理学核心（BiPC，核心 1），一个生物样本库和多方面的研究资源由经验丰富的神经病理学家和细胞生物学家以及持续活跃的研究专业知识组成，将提供关键的支持 UCLA SPORE 中提出的转化预后、诊断和治疗研究脑癌。与生物统计学、生物信息学和数据管理核心（BBD、Core 3)、BiPC 将最大限度地优化生物样本收集/存储以及有效支付经同意的、临床注释和分子特征的生物样本。该核心将支持所有四个 SPORE 具有 24/7 组织采购、临床和家族史注释以及分子特征的项目组织，加上神经胶质瘤球/神经球培养、组织微阵列和患者来源的研究支持原位异种移植物（PDOX）。生物样本和病理学核心联合主任和研究人员拥有彼此之间以及与所有 SPORE 项目负责人都有悠久的合作历史，如联合所示出版物、赠款和财团。除了优秀的采集、处理、存储程序，和传播重要的生物样本以支持拟议的 SPORE 研究项目，BiPC 议程远远超出了这些核心职能，还涉及新科学方法的创新发展最大限度地收集稀有/稀疏标本并开发新的动物模型治疗药物的发现。作为该核心的一部分，在动物体内生长的脑癌细胞将经过特殊改造具有荧光标记，以便在体内连续跟踪肿瘤的生长或缩小对动物进行实验性治疗。 BiPC 将开发并提供这些材料，向加州大学洛杉矶分校内外的 SPORE 研究人员和其他人提供资源和信息。一个由经验丰富、有成就、坚定和富有成效的研究人员组成的优秀团队为该生物样本和病理学核心组装。它还在优秀的机构方面拥有强有力的承诺协作环境，这将有助于确保 SPORE 提案总体目标的成功。