Remote observed dosing to improve Suboxone compliance in clinical practice

远程观察给药以提高临床实践中的 Suboxone 依从性

基本信息

批准号：
9982921
负责人：
KYLE Matthew KAMPMAN
金额：
$ 24.15万
依托单位：
UNIVERSITY OF PENNSYLVANIA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9982921
关键词：
Abstinence Accounting Address Adherence Agonist American Attention Behavior Therapy Behavior monitoring Buprenorphine Cellular Phone Cessation of life Chronic Cognitive Communicable Diseases Communities Control Groups Counseling Data Dose Drug Screening Effectiveness Emergency department visit Evaluation Funding Goals HIV Health Health Services Accessibility Hepatitis B Hepatitis C Individual Intervention Logistics Matched Group Measures Medical Medication Management Methadone Methodology Monitor Moods Morbidity - disease rate Opioid Outcome Measure Outpatients Overdose Participant Patient Self-Report Patients Pennsylvania Pharmaceutical Preparations Physicians Physicians&apos Offices Private Practice Process Public Health Randomized Randomized Clinical Trials Records Regulation Relapse Risk Risk Behaviors Sampling Screening Result Secure Suboxone Surveys Telephone Testing Treatment outcome Universities Urine Visit Weight Gain Withdrawal addiction attentional control base behavioral pharmacology buprenorphine treatment clinical care clinical practice cost design effective therapy experimental group health disparity illicit drug use improved innovation medication compliance methadone treatment misuse of prescription only drugs opioid agonist therapy opioid mortality opioid use opioid use disorder overdose death overdose risk prescription opioid prescription pain reliever primary care setting primary outcome programs recruit secondary outcome side effect substance abuse treatment treatment program treatment research urinary

项目摘要

PROJECT SUMMARY Opioid Use Disorder (OUD) is a major public health problem. Although several effective treatments that mitigate withdrawal and promote abstinence have been developed and are widely used, physicians have expressed hesitation in prescribing them due to misuse and diversion. The most recent of these treatments, buprenorphine (Suboxone®), can be prescribed by physicians in private practice. While Suboxone® has a lower abuse liability and decreased risk of overdose than methadone, compliance is low and diversion is an ongoing problem. The goal of this project is to develop and test the preliminary efficacy of using remote compliance monitoring in buprenorphine (Suboxone®) treatment for OUD. To that end, 40 subjects with OUD will be recruited through the University of Pennsylvania's Treatment Research Center, an outpatient substance abuse treatment facility. All subjects will receive a smartphone (and data plan); buprenorphine (Suboxone®) (16 mg/day, adjusted as needed according to individual requirements); and counseling in the form of weekly Medication Management (MM) for 12 weeks. Participants will be randomized into one of two groups: remote compliance monitoring or an attention match group that mirrors current clinical care. Using an iterative process we propose to develop an innovative, low cost, and scalable platform physicians can easily integrate into their private practice. Findings from the study will be used to support an R01 application to test the use of remote compliance monitoring in a larger prescription opiate-dependent sample in clinical practices. This methodology has broad applications for increased compliance in office-based treatment for addiction and other chronic medical conditions.

项目摘要阿片类药物使用障碍（OUD）是一个主要的公共卫生问题。虽然几种有效的治疗方法已经开发了缓解戒断和戒酒的戒断，并且已被广泛使用，医生已经由于小姐和转移而对它们开处方表示犹豫。这些治疗方法中的最新丁丙诺啡（Suboxone®）可以由私人执业中的医生开处方。而suboxone®有滥用责任较低，服用过量的风险比Meadadone较低，合规性低，转移是一种正在进行的问题。该项目的目的是开发和测试使用远程的初步效率丁丙诺啡（Suboxone®）治疗OUD的合规性监测。为此，有40位带有Oud的主题将通过宾夕法尼亚大学的治疗研究中心招募，该研究中心是门诊滥用治疗设施。所有受试者都将收到智能手机（和数据计划）；丁丙诺啡（Suboxone®）（每天16毫克，根据个人要求根据需要进行调整）；并以每周的形式进行咨询药物管理（MM）12周。参与者将被随机分为两个组之一：远程合规性监测或反映当前临床护理的注意匹配组。使用迭代过程我们建议开发一种创新，低成本和可扩展的平台医师可以轻松地集成到他们的私人执业。研究结果将用于支持R01应用程序以测试遥控器的使用在临床实践中，较大的处方优化依赖性样本中的合规性监测。这种方法在基于办公室的成瘾和其他慢性的基础治疗方面有广泛的申请，以提高遵守情况医疗状况。