Collaborative Research Training in Thrombosis and Inflammation

血栓和炎症合作研究培训

• 批准号: 9983169
• 负责人: Miguel Angel Cruz
• 金额: $ 34.44万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9983169
• 关键词: Inflammation; Research Training; Thrombosis

This new T32 program will prepare postdoctoral trainees for collaborative research careers in two inter-related topics: thrombosis and inflammation. There is increasing evidence of a direct relationship between thrombosis and inflammation in numerous human diseases. As examples, inflammation contributes to the pathogenesis of thrombotic disorders such as stroke and coronary artery disease, while thrombosis influences disease severity in conditions associated with inflammation including sepsis, autoimmune diseases and cancer. While thrombosis and inflammation frequently coexist, to our knowledge, this will be the only T32 program in the nation with a primary focus on both processes. The Center for Translational Research on Inflammatory Diseases (CTRID) at Michael E. DeBakey VA Medical Center and the Division of Thrombosis Research at Baylor College of Medicine will sponsor this collaborative training program with rigorous research opportunities and close mentoring by faculty. The group of 17 faculty mentors includes 14 NIH-funded investigators and 6 VA Merit-funded investigators; 12 of the mentors are physician-scientists and the balance non-physician scientists. The major strengths of our program include: 1) a cohesive and highly collaborative group of successful mentors with research expertise in relevant topics for our program, including platelets, neutrophils, microvascular thrombosis, stroke, cancer, sepsis, inflammatory conditions in kidney, lung, and bone, among others; 2) a unique combined curriculum with shared didactic and clinically- oriented training for physician and non-physician trainees; and 3) it is based in a thriving research center committed to mentoring, including a weekly seminar series that consists of > 60% speakers with scientific interests aligned with the themes of this T32. In addition to training physician-scientists in biomedical research, PhD scientists will be trained in translational medicine offering a direct interaction with patients with clinical conditions related to the focus of this T32. PhD trainees will be paired with physician trainees during these clinical practicums; this collaborative aspect of the program will teach PhD postdoctoral fellows the importance and benefit of conducting research in collaboration with physician-scientists and vice-versa. The program consists of 2-3 years of research training, enriched by didactic courses, an outstanding seminar series and a vibrant scientific environment. Successful implementation of this T32 in Thrombosis and Inflammation will pave the way for new biological insights and novel ways of prevention and treatment of thrombotic-inflammatory disorders by educating future physician- and non-physician scientists for collaborative research careers in thrombosis and inflammation.

这个新的T32计划将为博士后学员准备合作研究职业 两个相互关联的主题：血栓形成和炎症。有越来越多直接的证据 在许多人类疾病中血栓形成与炎症之间的关系。作为例子， 炎症有助于血栓性疾病（例如中风）的发病机理 冠状动脉疾病，而血栓形成影响相关条件下的疾病严重程度 炎症，包括败血症，自身免疫性疾病和癌症。而血栓形成和 据我们所知，炎症经常共存，这将是全国唯一的T32计划 主要关注这两个过程。炎症转化研究中心 Michael E. Debakey VA医疗中心的疾病（CTRID）和血栓形成师 贝勒医学院的研究将赞助这项合作培训计划 严格的研究机会和教师的密切指导。 17名教师导师 包括14位由NIH资助的调查人员和6名VA绩效资助的调查人员； 12个导师是 医师科学家和平衡非医学科学家。我们的主要优势 程序包括：1）与 我们计划的相关主题的研究专业知识，包括血小板，中性粒细胞， 微血管血栓形成，中风，癌症，败血症，肾脏，肺和炎症状况 骨头等； 2）独特的结合课程，具有共同的教学和临床 - 针对医师和非医师学员的定向培训； 3）它基于繁荣 致力于指导的研究中心，包括每周一次的研讨会系列，包括> 具有科学利益的60％发言人与该T32的主题保持一致。除了训练 生物医学研究的医师科学家，博士学位科学家将接受翻译的培训 与具有临床状况的患者直接相互作用的药物与重点有关 这个T32。在这些临床实习期间，博士生将与医师学员配对；这 该计划的协作方面将教授博士博士后研究员的重要性和 与医师科学家合作进行研究的好处，反之亦然。这 计划包括2 - 3年的研究培训，由教学课程丰富，这是一门杰出的课程 研讨会系列和充满活力的科学环境。成功实施了此T32 血栓形成和炎症将为新的生物学见解和新颖方式铺平道路 通过教育未来的医生来预防和治疗血小板炎症疾病 - 以及非物理学的科学家，从事血栓形成和炎症方面的合作研究职业。