Collaborative Research Training in Thrombosis and Inflammation

血栓和炎症合作研究培训

• 批准号: 9983169
• 负责人: Miguel Angel Cruz
• 金额: $ 34.44万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9983169
• 关键词: Inflammation; Research Training; Thrombosis

This new T32 program will prepare postdoctoral trainees for collaborative research careers in two inter-related topics: thrombosis and inflammation. There is increasing evidence of a direct relationship between thrombosis and inflammation in numerous human diseases. As examples, inflammation contributes to the pathogenesis of thrombotic disorders such as stroke and coronary artery disease, while thrombosis influences disease severity in conditions associated with inflammation including sepsis, autoimmune diseases and cancer. While thrombosis and inflammation frequently coexist, to our knowledge, this will be the only T32 program in the nation with a primary focus on both processes. The Center for Translational Research on Inflammatory Diseases (CTRID) at Michael E. DeBakey VA Medical Center and the Division of Thrombosis Research at Baylor College of Medicine will sponsor this collaborative training program with rigorous research opportunities and close mentoring by faculty. The group of 17 faculty mentors includes 14 NIH-funded investigators and 6 VA Merit-funded investigators; 12 of the mentors are physician-scientists and the balance non-physician scientists. The major strengths of our program include: 1) a cohesive and highly collaborative group of successful mentors with research expertise in relevant topics for our program, including platelets, neutrophils, microvascular thrombosis, stroke, cancer, sepsis, inflammatory conditions in kidney, lung, and bone, among others; 2) a unique combined curriculum with shared didactic and clinically- oriented training for physician and non-physician trainees; and 3) it is based in a thriving research center committed to mentoring, including a weekly seminar series that consists of > 60% speakers with scientific interests aligned with the themes of this T32. In addition to training physician-scientists in biomedical research, PhD scientists will be trained in translational medicine offering a direct interaction with patients with clinical conditions related to the focus of this T32. PhD trainees will be paired with physician trainees during these clinical practicums; this collaborative aspect of the program will teach PhD postdoctoral fellows the importance and benefit of conducting research in collaboration with physician-scientists and vice-versa. The program consists of 2-3 years of research training, enriched by didactic courses, an outstanding seminar series and a vibrant scientific environment. Successful implementation of this T32 in Thrombosis and Inflammation will pave the way for new biological insights and novel ways of prevention and treatment of thrombotic-inflammatory disorders by educating future physician- and non-physician scientists for collaborative research careers in thrombosis and inflammation.

这个新的 T32 项目将为博士后学员的合作研究生涯做好准备 两个相互关联的主题：血栓形成和炎症。越来越多的证据表明直接 许多人类疾病中血栓形成和炎症之间的关系。作为例子， 炎症有助于血栓性疾病的发病机制，例如中风和 冠状动脉疾病，而血栓形成会影响相关疾病的严重程度 患有炎症，包括败血症、自身免疫性疾病和癌症。虽然血栓和 炎症经常并存，据我们所知，这将是全国唯一的T32项目 主要关注这两个过程。炎症转化研究中心 Michael E. DeBakey VA 医疗中心和血栓科的疾病 (CTRID) 贝勒医学院的研究将赞助该合作培训项目 严格的研究机会和教师的密切指导。导师团队17人 包括 14 名 NIH 资助的研究人员和 6 名 VA Merit 资助的研究人员；其中12位导师是 医师科学家和平衡的非医师科学家。我们的主要优势 计划包括：1）一个有凝聚力和高度协作的成功导师团队 我们项目相关主题的研究专业知识，包括血小板、中性粒细胞、 微血管血栓形成、中风、癌症、败血症、肾脏、肺部和肺部炎症 骨头等； 2）独特的综合课程，具有共享的教学和临床- 针对医师和非医师实习生的定向培训； 3）它建立在一个蓬勃发展的基础上 研究中心致力于指导，包括每周一次的研讨会系列，其中包括> 60% 的演讲者的科学兴趣与本 T32 的主题一致。除了训练 从事生物医学研究的医师科学家、博士科学家将接受转化培训 医学提供与临床状况相关的患者的直接互动 这个T32。在这些临床实习期间，博士生将与实习医生配对；这 该计划的合作方面将向博士后研究员传授重要性和 与医生科学家合作进行研究的好处，反之亦然。这 计划包括 2-3 年的研究培训，并通过教学课程进行丰富，这是一个杰出的 系列研讨会和充满活力的科学环境。 T32 的成功实施 血栓形成和炎症将为新的生物学见解和新的治疗方法铺平道路 通过教育未来的医生来预防和治疗血栓性炎症性疾病 以及非医师科学家在血栓形成和炎症方面的合作研究事业。