13/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT MUSC

13/21 ABCD-美国联盟：MUSC 研究项目现场

• 批准号: 9981294
• 负责人: Kevin M Gray
• 金额: $ 118.67万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9981294
• 关键词: 10 year old; Address; Adolescence; Adolescent; Adult; Affect; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Anxiety; Athletic Injuries; Behavior; Behavioral; Bioinformatics; Biological; Biological Assay; Biology; Brain; Brain imaging; Caffeine; Calendar; Cannabis; Child; Child Health; Childhood; Clinical assessments; Cognition; Cognitive; Communities; Country; Data; Data Analyses; Decision Making; Development; Emotional; Enrollment; Ensure; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiology; Ethics; Event; Feeling suicidal; Female; Funding; Genetic; Health; Impairment; Individual; Informatics; Interview; Life; Link; Logistics; Longitudinal Studies; Mental Depression; Mental Health; Mental disorders; Methodology; Methods; Monitor; Neurocognition; Neurocognitive; Neuropsychological Tests; Occupations; Outcome; Parents; Participant; Pathway interactions; Persons; Physical activity; Process; Protocols documentation; Psychopathology; Registries; Research; Research Personnel; Research Project Grants; Resource Informatics; Resources; Risk; Role; Sampling; Schools; Science; Secure; Severities; Siblings; Site; Sleep; Social Functioning; Social isolation; Specific qualifier value; Sports; Standardization; Symptoms; Technology; Teenagers; Telephone; Text; Time; Tobacco; Tobacco use; Training; Traumatic Brain Injury; Triplet Multiple Birth; Twin Multiple Birth; United States; Video Games; Youth; adolescent substance use; adverse outcome; cognitive development; cognitive testing; cohort; college; design; emerging adult; emotional factor; experience; follow-up; gene interaction; informatics infrastructure; marijuana use; mobile application; mobile computing; multimodality; neurodevelopment; neuroimaging; novel; participant retention; physical conditioning; recruit; relating to nervous system; research and development; response; retention rate; sleep pattern; social; social media; temporal measurement; trend; tv watching; vaping; young adult

Abstract Adolescent Brain Cognitive Development (ABCD) is the largest long-term study of brain development and child health in the United States. The ABCD Research Consortium consists of 21 research sites across the country, a Coordinating Center, and a Data Analysis and Informatics Resource Center. In its first five years, under RFA-DA-15-015, ABCD enrolled a diverse sample of 11,878 9-10 year olds from across the consortium, and will track their biological and behavioral development through adolescence into young adulthood. All participants received a comprehensive baseline assessment, including state-of-the-art brain imaging, neuropsychological testing, bioassays, careful assessment of substance use, mental health, physical health, and culture and environment. A similar detailed assessment recurs every 2 years. Interim in-person annual interviews and mid-year telephone or mobile app assessments provide refined temporal resolution of developmental changes and life events that occur over time with minimal burden to participating youth and parents. Intensive efforts are made to keep the vast majority of participants involved with the study through adolescence and beyond, and retention rates thus far are very high. Neuroimaging has expanded our understanding of brain development from childhood into adulthood. Using this and other cutting-edge technologies, ABCD can determine how different kinds of youth experiences (such as sports, school involvement, extracurricular activities, videogames, social media, unhealthy sleep patterns, and vaping) interact with each other and with a child's changing biology to affect brain development and social, behavioral, academic, health, and other outcomes. Data, securely and privately shared with the scientific community, will enable investigators to: (1) describe individual developmental pathways in terms of neural, cognitive, emotional, and academic functioning, and influencing factors; (2) develop national standards of healthy brain development; (3) investigate the roles and interaction of genes and the environment on development; (4) examine how physical activity, sleep, screen time, sports injuries (including traumatic brain injuries), and other experiences influence brain development; (5) determine and replicate factors that influence mental health from childhood to young adulthood; (6) characterize relationships between mental health and substance use; and (7) specify how use of substances such as cannabis, alcohol, tobacco, and caffeine affects developmental outcomes, and how neural, cognitive, emotional, and environmental factors influence the risk for adolescent substance use.

抽象的 青少年脑认知发展（ABCD）是大脑发育和儿童的最大长期研究 美国的健康。 ABCD研究联盟由全国21个研究地点组成， 协调中心，以及数据分析和信息资源中心。在最初的五年中 RFA-DA-15-015，ABCD从财团中招募了11,878个9-10岁的不同样本， 将通过青春期到成年后的青春期来跟踪其生物学和行为发展。 所有参与者都接受了全面的基线评估，包括最先进的大脑成像， 神经心理学测试，生物测定，仔细评估药物使用，心理健康，身体健康， 以及文化和环境。类似的详细评估每两年复发。临时面对面年度 访谈和年中电话或移动应用程序评估提供了精致的时间分辨率 随着时间的推移发生的发展变化和生活事件，年轻人的负担最小， 父母。尽力使绝大多数参与者通过 青春期及以后，到目前为止的保留率很高。神经影像扩大了我们的 了解从童年到成年的大脑发育。使用这个和其他尖端 技术，ABCD可以确定不同种类的青年体验（例如体育，学校 参与，课外活动，电子游戏，社交媒体，不健康的睡眠方式和烟） 彼此互动，并与孩子的生物学变化，以影响大脑发展和社会行为，行为， 学术，健康和其他成果。 与科学界安全和私人共享的数据将使研究人员能够：（1）描述 就神经，认知，情感和学术功能而言，个人发育途径 影响因素； （2）发展健康大脑发展的国家标准； （3）调查角色和 基因与发展环境的相互作用； （4）检查体育锻炼，睡眠，屏幕如何 时间，运动损伤（包括脑部受伤）以及其他经历会影响脑发育； （5） 确定并复制影响从童年到成年的心理健康的因素； （6） 表征心理健康与使用物质之间的关系； （7）指定物质的使用方式 例如大麻，酒精，烟草和咖啡因会影响发育结果，以及神经，认知，如何 情绪和环境因素会影响青少年物质使用的风险。