Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment

磁共振成像用于全球动脉粥样硬化风险评估

• 批准号: 9980464
• 负责人: Janet Wei
• 金额: $ 19.84万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9980464
• 关键词: Apolipoproteins B; Area; Arterial Fatty Streak; Atherosclerosis; Biological Markers; Biometry; C-reactive protein; Cardiac; Cardiology; Cardiovascular Diseases; Cause of Death; Clinical; Clinical Trials; Contrast Media; Coronary; Coronary Arteriosclerosis; Development; Discrimination; Effectiveness; Epidemiology; Event; Future; Glycosylated hemoglobin A; Hemorrhage; High Density Lipoprotein Cholesterol; Individual; Intervention; LDL Cholesterol Lipoproteins; Laboratories; Learning; Lesion; Lipoprotein (a); Magnetic Resonance Imaging; Measurement; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Modeling; Monitor; Myocardial Infarction; Patients; Prevention strategy; Prevention trial; Preventive; Recording of previous events; Recurrence; Reproducibility; Research Methodology; Resolution; Risk; Risk Assessment; Risk Factors; Secondary Prevention; Stroke; Techniques; Thick; Time; Training; Translational Research; United States; Weight; acute coronary syndrome; adiponectin; atherosclerosis risk; cardiovascular disorder prevention; cardiovascular disorder risk; cardiovascular imaging; cardiovascular risk factor; career; clinical application; clinically significant; coronary calcium scoring; coronary computed tomography angiography; design; high risk; improved; individual patient; mortality; novel; novel therapeutics; personalized intervention; prognostic value; public health relevance; rapid technique; recruit; tool; translational scientist; treatment response; treatment strategy; vascular bed

 DESCRIPTION (provided by applicant): This application for a Mentored Patient-Oriented Research Career Development Award entitled "Magnetic Resonance Imaging for Global Atherosclerosis Risk Assessment" is being submitted by Janet Wei, MD, to continue her professional development as a translational researcher in the inter-disciplinary field of preventive cardiology and magnetic resonance imaging (MRI) measures of atherosclerosis. Cardiovascular disease (CVD) remains the leading cause of death in the United States. Secondary prevention strategies reduce but do not eliminate the risk of recurrent CVD events and many patients are treated to reduce one event. Current risk prediction is not personalized to an individual patient's atherosclerotic burden or adverse plaque features, which have now been shown to have prognostic value. Current measures of atherosclerosis burden and adverse plaque features in individual vascular beds improve prediction of CVD events over traditional risk factors, but their clinical application is not developed for risk prediction of recurrent evens or for therapeutic response monitoring. Novel techniques have been developed for assessing coronary, carotid, and femoral atherosclerosis using MRI methods that are rapid and reproducible, have improved spatial resolution, and do not require contrast media, making atherosclerosis assessment in multiple vascular beds feasible. Because the coronary vascular bed has greater risk assessment value for cardiac events than the carotid and femoral vascular beds, Dr. Wei hypothesizes that global MRI measures of plaque burden and adverse plaque features using all three vascular beds will improve CVD risk discrimination compared to currently available individual vascular bed measures and may be useful to monitor treatment response. The proposed project builds on Dr. Wei's strengths in general clinical cardiology and basic cardiovascular imaging, and she will receive additional training in [1] CVD prevention and epidemiology, [2] MRI quantification and characterization of atherosclerotic plaque, and [3] advanced biostatistics and research methodology for risk prediction. She anticipates that this training will give her the tools to apply MRI atherosclerosis models in clinical trials for the development of personalized CVD prevention and treatment strategies.

 描述（由应用程序提供）：该申请的申请名为“全球动脉粥样硬化风险评估的磁性共振成像”，MD正在提交，以继续她作为预防性心脏病学和磁共振成像（MRI）测量的跨学科研究人员的专业发展。心血管疾病（CVD）仍然是美国死亡的主要原因。二级预防策略减少但不会消除复发性CVD事件的风险，许多患者被治疗以减少一个事件。当前的风险预测未针对个体患者的动脉粥样硬化烧伤或不良斑块特征进行个性化，这些特征现已被证明具有预后价值。动脉粥样硬化燃烧和单个血管床中不良斑块特征的当前度量改善了CVD事件的预测，而不是传统危险因素的预测，但是它们的临床应用并未开发出来用于复发性EVENS或治疗反应监测的风险预测。已经开发了用于使用快速且可重现的MRI方法评估冠状动脉，颈动脉和股动脉粥样硬化的新型技术，具有改善的空间分辨率，不需要对比培养基，从而在多个血管床中评估动脉粥样硬化评估。由于冠状动脉血管床比颈动脉和股骨血管床具有更大的风险评估价值，因此WEI博士假设，使用所有三个血管床的全球MRI测量值与当前可用的单个血管床测量及其有用的响应相比，使用所有三个血管床可以改善CVD风险区分的全球MRI测量。拟议的项目以WEI博士在一般临床心脏病学和基本心血管成像中的优势为基础，她将在[1] CVD预防和流行病学方面接受额外的培训，[2] MRI量化和动脉粥样硬化斑块的特征，以及[3]先进的生物统计学和研究方法进行风险预测。她预计这项培训将为她提供在临床试验中应用MRI动脉粥样硬化模型的工具，以开发个性化的CVD预防和治疗策略。

项目成果

Case report: assessment and management of myocardial infarction and non-obstructive coronary arteries (MINOCA): the role of microvascular coronary vasospasm.

病例报告：心肌梗塞和非阻塞性冠状动脉（MINOCA）的评估和治疗：微血管冠状动脉痉挛的作用。

• DOI: 10.21037/cdt.2019.07.13
• 发表时间: 2019
• 期刊: Cardiovascular diagnosis and therapy
• 影响因子: 2.4
• 作者: Marpuri,ReddySailaja;Joung,Sandy;Gadh,Adit;Dhawan,Shivani;Al-Badri,Ahmed;Pacheco,Christine;Wei,Janet;Merz,CNoelBairey
• 通讯作者: Merz,CNoelBairey