Claude D. Pepper Older Americans Independence Center at Yale

耶鲁大学克劳德·D·佩珀美国老年人独立中心

• 批准号: 9976411
• 负责人: Thomas Michael Gill
• 金额: $ 113.41万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9976411
• 关键词: Address; Affect; Aging; American; Animals; Behavioral; Bioinformatics; Biological; Biometry; Capsicum; Center Core Grants; Clinical; Clinical Sciences; Clinical Trials; Collaborations; Complex; Development; Discipline; Disease; Elderly; Environment; Epidemiology; Fostering; Funding; Future; Genetic; Geroscience; Goals; Grant; Health; Health Services; Impairment; Interdisciplinary Study; Intervention; Investigation; Investments; Knowledge; Leadership; Manuscripts; Measures; Medical; Medicine; Minority; Mission; Modeling; Molecular; Outcome; Physiological; Pilot Projects; Precipitating Factors; Predisposing Factor; Progress Reports; Publications; Research; Research Personnel; Research Training; Role; Scientific Advances and Accomplishments; Techniques; Testing; Training; base; career development; clinical decision-making; cost; design; education research; effective therapy; falls; functional independence; innovation; investigator training; knowledge base; multiple chronic conditions; operation; psychologic; recruit; skills; social; sociodemographics

The overarching mission of the Yale Older Americans Independence Center (OAIC), established in 1992, is to provide intellectual leadership and innovation for aging research that is directed at enhancing the independence of older persons. The unifying theme of the Yale OAIC remains the investigation of multifactorial geriatric conditions, encompassing single conditions resulting from multiple contributing factors or affecting multiple outcome domains and multiple conditions occurring simultaneously. The central Yale OAIC hypothesis is that geriatric conditions are determined by the co-occurrence of multiple predisposing and precipitating factors. These conditions and factors, in turn, affect a range of health outcomes. The predisposing factors may be at the genetic, molecular, physiologic, impairment, disease, or socio-demographic level, while the precipitating factors may be behavioral, environmental, social, medical, or psychological. The Yale OAIC theme requires designs and models (e.g. molecular, animal, and statistical) that inform the study of multiple, simultaneously interactive factors and outcomes. As a prominent subtheme, the Yale OAIC also aims to advance the science of clinical decision making in the face of trade-offs and multiple competing outcomes. This includes developing strategies to elicit older persons’ health outcome priorities. The Specific Aims of the Yale OAIC are to: 1) foster the career development of future academic leaders, from multiple disciplines, in aging research; 2) train investigators, biostatisticians and other methodologists in the skills necessary to design, conduct, analyze, and disseminate findings from studies of multifactorial geriatric conditions; 3) develop and disseminate design and analytic techniques for conducting studies of multifactorial geriatric conditions; 4) develop strategies for recruiting into, and retaining, a broad spectrum of older persons, including minorities, into studies of multifactorial geriatric conditions; 5) investigate the causative mechanisms of, and develop and test effective treatments for, geriatric conditions from a multifactorial research perspective; 6) develop strategies to enhance clinical decision making in the setting of multiple competing outcomes; 7) encourage and facilitate interdisciplinary research (basic, translational and clinical) that connects to our focus on multifactorial geriatric conditions; and 8) further strengthen collaborations with other OAICs. The Yale OAIC cores include: 1) Leadership and Administrative; 2) Research Education; 3) Pilot/Exploratory Studies; 4) Operations; and 5) Biostatistics. For the first one to two years of the next cycle, we propose to support 3 Pepper Scholars, 3 pilot studies, 2 development projects, and 29 externally funded projects. The Yale OAIC has made outstanding progress during the current funding cycle, as evidenced by publication of 411 manuscripts (with an additional 23 submitted) and receipt of more than $178 million in grants (total costs), with an additional $16.3 million pending. Based on grants received, the return on investment from OAIC support is more than 20 to 1.

耶鲁大学美国老年人独立中心 (OAIC) 成立于 1992 年，其首要任务是 为老龄化研究提供智力领导和创新，旨在增强 耶鲁大学 OAIC 的统一主题仍然是对多因素的调查。 老年病，包括由多种影响因素引起或影响的单一病症 多个结果领域和多个条件同时发生。 假设认为，老年病是由多种易感因素和多种因素同时发生所决定的。 这些条件和因素反过来会影响一系列的健康结果。 因素可能在遗传、分子、生理、损伤、疾病或社会人口层面，而 诱发因素可能是行为、环境、社会、医学或心理。 主题需要设计和模型（例如分子、动物和统计）来为多种研究提供信息， 作为一个突出的副主题，耶鲁大学 OAIC 还旨在 面对权衡和多种竞争结果，推进临床决策的科学性。 包括制定战略来确定老年人的健康结果优先事项。 耶鲁大学 OAIC 的具体目标是： 1) 促进未来学术领袖的职业发展， 来自多个学科的衰老研究人员；2) 培训研究人员、生物统计学家和其他方法学家 设计、进行、分析和传播多因素研究结果所需的技能 老年疾病；3) 开发和传播用于进行研究的设计和分析技术 4) 制定招募和保留广泛的战略 老年人，包括少数民族，参与多因素老年病的研究 5) 调查病因； 通过多因素研究研究老年疾病的机制，并开发和测试有效的治疗方法 6) 制定策略以在多重竞争的情况下加强临床决策 成果；7）鼓励和促进跨学科研究（基础、转化和临床） 重点关注多因素老年病；8) 进一步加强与其他 OAIC 的合作。 耶鲁大学 OAIC 核心包括：1) 领导力和管理；2) 研究教育；3) 试点/探索性； 研究；4) 运营；以及 5) 生物统计。 支持 3 名胡椒学者、3 项试点研究、2 个开发项目和 29 个外部资助项目。 耶鲁大学 OAIC 在当前的资助周期中取得了显着的进展，如下所示： 发表 411 份手稿（另外提交了 23 份）并获得超过 1.78 亿美元的资助 （总成本），还有 1630 万美元待决，根据收到的赠款，投资回报。 OAIC 的支持比例超过 20 比 1。