Cognitive Health, Psychosocial factors, and behaviors relevant to aging successfully with HIV

认知健康、心理社会因素和与艾滋病毒成功老龄化相关的行为

• 批准号: 9976087
• 负责人: Annie Lu Nguyen
• 金额: $ 12.84万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9976087
• 关键词: Address; Adherence; Adult; Age; Aging; Alcohol or Other Drugs use; Alzheimer' s Disease; Attention Concentration; Behavior; Biometry; Buffers; Caring; Characteristics; Chronic; Cognition; Cognitive; Cognitive deficits; Community Health; Consequences of HIV; Continuity of Patient Care; Data Analyses; Data Collection; Dementia; Development; Elderly; Exposure to; Goals; HIV; HIV Infections; HIV antiretroviral; HIV-associated neurocognitive disorder; Health; Health Benefit; Health Promotion; Health Resources; Health behavior; Impaired cognition; Impairment; Individual; Intervention; K-Series Research Career Programs; Lead; Leisure Activities; Life; Life Cycle Stages; Life Expectancy; Life Stress; Longevity; Memory; Mental Depression; Mental Health; Neurologic; Outcome; Participant; Perception; Persons; Physical activity; Play; Population; Psyche structure; Psychosocial Factor; Public Health; Quality of life; Research; Research Activity; Research Design; Research Personnel; Resources; Risk; Role; Social support; Stigmatization; Stress; Time; Training; aging population; antiretroviral therapy; behavioral health; career; cohort; comorbidity; demographics; design; disability; experience; falls; improved; innovation; multiple data sources; neurobehavioral; population health; programs; psychosocial; research study; social stigma; stressor; therapy adherence

PROJECT SUMMARY/ABSTRACT Advancements in therapy have drastically improved life expectancy for people living with HIV and many individuals are living well into older adulthood. Older adults living with HIV, defined as those who are 50 years and older, make up almost half of all individuals living with HIV in the US. Although life expectancy has increased, older adults living with HIV have greater risk for multiple physical, mental, and psychosocial health burdens compared to uninfected older adults. It is well documented that people living with HIV are at increased risk for impaired cognition, including cognitive impairment leading to dementia and Alzheimer’s Disease, and HIV associated neurocognitive disorders (HAND). The consequences of cognitive impairment among this population have far reaching implications for population and public health. Impaired individuals may lose the ability to fully engage in activities involved in HIV care, such as adherence to antiretroviral therapies. Impaired individuals may also lose the ability to fully engage in other health promoting and beneficial behaviors such as participate in physical and leisure activities, and activate or utilize positive resources like social support, purpose in life, and financial resources. Taken within a broader life course context, having multiple life stressors may also negatively impact the ability to engage in health behaviors and resources and influence cognitive outcomes. However, research has yet to disentangle the impact of cognition on engagement in healthy behaviors within the context of positive resource utilization in older adults with HIV. A greater understanding of this is needed given the aging of the population living with HIV and the corresponding public health burden. The overall goals of the proposed Career Development Award (K01) goals are to investigate the relationship between cognitive deficits and health promoting behaviors, clarify the moderating role of positive resources, and to determine the cumulative impact of these interactions on quality of life for older adults experiencing stress while living with HIV. This will be achieved through the completion of the proposed training plan, organized under the four content domains of cognition, HIV and aging, biostatistics and longitudinal research design, and professional development. This training plan was designed with the goal of launching the PI’s career as an independent investigator with a research program focused on the interplay of cognition, psychosocial factors, and life stress on health and successful aging in individuals aging with HIV.

项目概要/摘要 治疗方法的进步极大地提高了艾滋病毒感染者和许多人的预期寿命 感染艾滋病毒的老年人（定义为 50 岁）已步入老年。 尽管预期寿命有所延长，但老年人和老年人几乎占美国所有艾滋病毒感染者的一半。 感染艾滋病毒的老年人在身体、精神和社会心理等多种方面面临更大的健康风险 与未感染的老年人相比，艾滋病毒感染者的负担有所增加。 认知受损的风险，包括导致痴呆和阿尔茨海默病的认知障碍，以及 HIV相关的神经认知障碍（HAND）其中认知障碍的后果。 人口对人口和公共健康产生深远影响。 充分参与艾滋病毒护理活动的能力，例如坚持抗逆转录病毒治疗。 个人也可能失去充分参与其他健康促进和有益行为的能力，例如 参加体育和休闲活动，激活或利用积极的资源，如社会支持、 在更广泛的生命历程背景下考虑人生目标和财务资源，拥有多种生活。 压力源还可能对参与健康行为和资源的能力产生负面影响，并影响 然而，研究尚未阐明认知对参与度的影响。 感染艾滋病毒的老年人在积极利用资源的情况下的健康行为。 鉴于艾滋病毒感染者人口的老龄化以及相应的公众，需要了解这一点 拟议职业发展奖（K01）的总体目标是调查健康负担。 认知缺陷与健康促进行为之间的关系，阐明积极的调节作用 资源，并确定这些相互作用对老年人生活质量的累积影响 这将通过完成拟议的培训来实现。 计划，根据认知、艾滋病毒和老龄化、生物统计学和纵向四个内容领域组织 该培训计划的设计目的是启动 PI 的职业生涯是作为一名独立调查员，其研究项目专注于认知的相互作用， 心理社会因素以及生活压力对艾滋病毒感染者健康和成功老龄化的影响。