Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients with High-Flow Nasal Cannula -the "I-CAN" study

使用高流量鼻插管降低高风险心脏手术患者的重新插管风险 -“I-CAN”研究

• 批准号: 9976965
• 负责人: Robert Edward Freundlich
• 金额: $ 17.37万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9976965
• 关键词: Academic Medical Centers; Address; Admission activity; Adult; Age; Anesthesiology; Area; Beds; Biometry; Board Certification; Calibration; Cannulas; Cardiac; Cardiac Surgery procedures; Cardiovascular system; Certification; Clinical Informatics; Clinical Research; Clinical Trials; Clinical Trials Design; Clinical and Translational Science Awards; Complex; Coronary Artery Bypass; Critical Care; Data; Decision Making; Development; Development Plans; Electronic Health Record; Environment; Event; Fellowship; Fostering; Foundations; Freedom; Funding; Future; Goals; Grant; Healthcare Systems; Hour; Humidifier; Hypoxia; Informatics; Intensive Care Units; Interdisciplinary Study; Intervention; Intubation; Leadership; Learning; Length of Stay; Measures; Mechanical ventilation; Mentors; Mentorship; Methodology; Methods; Modeling; Nose; Operative Surgical Procedures; Oxygen; Patient-Focused Outcomes; Patients; Perioperative; Perioperative Care; Physician Executives; Physicians; Population; Postoperative Period; Pragmatic clinical trial; Prospective Studies; Protocols documentation; Provider; Randomized; Randomized Controlled Trials; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Risk; Risk Factors; Scientist; Statistical Models; Supervision; System; Techniques; Testing; Time; Training; United States; Validation; Weaning; Work; career; career development; clinical care; cohort; comorbidity; comparative effectiveness trial; cost; data tools; data warehouse; effective intervention; experience; high risk; improved; informatics tool; leadership development; mortality; novel; predictive modeling; pressure; prevent; professor; programs; research and development; skills; targeted treatment; treatment as usual

PROJECT SUMMARY Candidate: Dr. Robert E. Freundlich, MD, MS is an Assistant Professor at Vanderbilt University Medical Center (VUMC). Dr. Freundlich has a strong background in clinical informatics, gained through his research fellowship and ongoing work as the Associate Medical Director of the Vanderbilt Anesthesiology and Perioperative Informatics Research Division (VAPIR). His long-term career plan is to become a physician- scientist capable of leveraging advanced informatics tools to conduct high quality pragmatic clinical trials in the intensive care unit and perioperative care. To achieve this, he will gain expertise in pragmatic clinical trial design, advanced use of a widely-available commercial electronic health record (EHR), executive leadership development, and board certification in clinical informatics. Research Project: More than half a million adult patients undergo cardiac surgery each year in the United States, 5-10% of whom will experience reintubation. Reintubation after cardiac surgery is associated with higher short- and long-term mortality, increased cost, and longer lengths of stay. As patients undergoing cardiac surgery are increasing in age, comorbidity burden, and receive increasingly complex cardiac surgical procedures, efforts to identify strategies that can effectively prevent reintubation are of critical importance. Career Development: Dr. Freundlich's career development plan integrates formal coursework with personalized training with his mentors and collaborators to 1) strengthen his methodologic foundation in the conduct of pragmatic comparative effectiveness trials; 2) develop expertise in the implementation of EHR- embedded clinical trial design; 3) advanced statistical modeling techniques to improve risk prediction; and 4) bolster his skills as a leader of a multi-disciplinary research team. Environment: VUMC is an established leader in biostatistics, perioperative informatics, and pragmatic clinical trial design and conduct. It is the ideal environment to foster Dr. Freundlich's development into a national leader in his field. Dr. Freundlich has identified experts at VUMC, each of whom is a leader in his or her field and will help mentor Dr. Freundlich towards his goal of research independence. Vanderbilt's Clinical and Translational Science Award (CTSA) funded “Learning Healthcare System”, intended to facilitate research that uses novel methods to integrate clinical research into clinical care, will help Dr. Freundlich as he works on the proposed research and career development plans.

项目概要 候选人：Robert E. Freundlich 博士，医学博士、理学硕士，范德比尔特大学医学院助理教授 Freundlich 博士通过他的研究获得了深厚的临床信息学背景。 范德比尔特麻醉科副医学主任的奖学金和正在进行的工作 围手术期信息学研究部（VAPIR）。他的长期职业计划是成为一名医生- 科学家能够利用先进的信息学工具在该领域进行高质量的实用临床试验 为了实现这一目标，他将获得实用临床试验方面的专业知识。 设计、广泛使用的商业电子健康记录 (EHR) 的高级使用、行政领导 临床信息学的开发和委员会认证。 研究项目：美国每年有超过 50 万成年患者接受心脏手术 州，其中 5-10% 的人会经历心脏手术后的重新插管。 更高的短期和长期死亡率、增加的费用和更长的住院时间。 心脏手术的年龄、合并症负担不断增加，并且接受的心脏手术也越来越复杂 程序，努力确定可有效防止再插管的策略至关重要。 职业发展：Freundlich 博士的职业发展计划将正式课程与 与他的导师和合作者一起进行个性化培训，以 1) 加强他在 进行务实的比较有效性试验；2）开发实施 EHR 的专业知识 嵌入式临床试验设计；3) 改进风险预测的先进统计建模技术； 增强他作为多学科研究团队领导者的技能。 环境：VUMC 是生物统计学、围手术期信息学和实用临床领域公认的领导者 这是促进弗罗因德利希博士发展成为国家级科学家的理想环境。 Freundlich 博士已经确定了 VUMC 的专家，每个人都是其领域的领导者。 并将帮助指导 Freundlich 博士实现范德比尔特临床和研究独立性的目标。 转化科学奖 (CTSA) 资助“学习医疗保健系统”，旨在促进以下研究： 使用新颖的方法将临床研究整合到临床护理中，将帮助 Freundlich 博士从事以下工作： 提出的研究和职业发展计划。