CPS-Cancer Prevention & Survivorship Research Program

CPS-癌症预防

基本信息

批准号：
9975744
负责人：
DAN ALAN DIXON
金额：
$ 5.84万
依托单位：
UNIVERSITY OF KANSAS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-11 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9975744
关键词：
Adolescent obesity Adult Animals Area Award Behavior Behavioral Biological Markers Biology Body Weight decreased Breast Cancer Biology Cancer Center Support Grant Cancer Control Cancer Survivor Cancer Survivorship Catchment Area Chemoprevention Clinical Collaborations Colon Colon Carcinoma Development Discipline of Nursing Disease Drug usage Event Exercise Physiology Funding Future Gastroenterology Grant Health Psychology Impaired cognition Individual Intervention Intervention Trial Journals Kansas Leadership Local Therapy Malignant - descriptor Malignant Neoplasms Malignant neoplasm of pancreas Malignant neoplasm of prostate Medical Oncology Mentors Missouri Modeling Molecular Myocardial dysfunction Natural Products Outcome Patient Outcomes Assessments Patients Peer Review Peer Review Grants Peripheral Nervous System Diseases Phase Physical activity Population Control Positioning Attribute Pre-Clinical Model Prevention Prevention strategy Prevention trial Preventive Intervention Primary Prevention Prostate Publications Publishing Quality of life Radiobiology Recurrence Research Research Personnel Resource Sharing Risk Rural Scientist Secondary Prevention Site Southwest Oncology Group Surgical Oncology Systemic Therapy Testing Tissues Translational Research Translations Underserved Population Work adult obesity analog base biomedical informatics breast cancer progression cancer prevention cohort comorbidity early phase trial energy balance high risk improved inter-institutional member metabolomics novel nutrition premalignant prevent programs response biomarker side effect success survivorship weight loss intervention

项目摘要

Cancer Prevention and Survivorship – Project Summary Cancer Prevention and Survivorship (CPS) focuses on pre-cancerous biology and its translation into initial testing of new prevention strategies, as well as interventions aimed at improving the quality of life for cancer survivors. In the Pre-Cancerous Biology and Risk Biomarkers theme, research centers on tissue changes that serve as indicators or predictors of malignant transformation and potential targets for developing new preventive strategies. In the Prevention and Survivorship Translational Research theme, basic scientists from the Pre-Cancerous Biology and Risk Biomarkers theme work with behavioral and clinical researchers for early testing of new strategies. CPS is unique from Cancer Control and Population Control (CCPH) in that CPS focuses on the discovery of new biomarkers and early phase testing of prevention and survivorship interventions using high-risk individuals, whereas CCPH focuses on implementation of known effective strategies. CPS has 21 full and 10 associate members from 16 departments/divisions with expertise in cancer biology, medical and surgical oncology, radiation biology, gastroenterology, nursing, clinical health psychology, nutrition, exercise physiology and biomedical informatics. In 2015, CPS increased the number of NCI (12) and total peer-reviewed (29) funded grants from 6 and 24 since 2011, the previous CCSG submission. Seven of the peer-reviewed grants are multi-PI awards, up from one. NCI and total peer-reviewed funding increased from $1,804,303 and $6,244,484 to $3,098,479 and $11,890,377. From 2012-2015, over 800 patients were accrued to 15 intervention trials. Twelve of these trials were investigator-initiated and three peer-reviewed funded. Kansas and Missouri have high rates of adult obesity. Thus, many of the CPS interventional trials focus on physical activity and weight reduction, in close collaboration with catchment area partners. CPS members have published 382 articles since 2012 of which 164 (43%) had intra-programmatic, 127 (33%) had inter-programmatic and 204 (54%) had inter-institutional collaborations. Forty-five publications (12%) had a journal impact factor ≥ 8. CPS contributes to KUCC with significant leadership (Director and three ADs, Chair PRMC, Co-chair SWOG Survivorship Committee) and highly translational biomarker based early phase prevention and survivorship trials often with parallel animal studies. The SWOG chair position helps move promising pilots into larger co-operative group trials. KUCC contributes to CPS both through shared resources and pilot funding. In the future, CPS will continue to build on its strengths of novel pre-cancerous models, new risk and response biomarkers, high-risk cohorts for early phase trials, energy balance and natural products in chemoprevention trials. CPS will increase collaborations with CB to expand biomarker research in metabolomics, with D3ET to develop natural product analogues for primary prevention and with CCPH to increase disparity and catchment area-relevant research, as well as educational initiatives and mentoring.

预防癌症和生存 - 项目摘要预防癌症和生存（CPS）着重于癌前生物学及其转化为初始生物学测试新的预防策略以及旨在改善癌症生活质量的干预措施幸存者。在癌前生物学和风险生物标志物主题中，研究中心变化的研究中心充当恶性转变的指标或预测指标，以及开发新的目标的潜在目标预防策略。在预防和生存转化研究主题中，来自癌前生物学和风险生物标志物主题与行为和临床研究人员一起工作测试新策略。 CPS在癌症控制和人群控制（CCPH）中是独一无二的着重于发现新的生物标志物和预防和生存的早期测试使用高风险个体的干预措施，而CCPH专注于实施已知有效的策略。 CPS拥有来自16个部门/部门的21名全面和10名员工，具有癌症专业知识生物学，医学和外科肿瘤学，放射生物学，胃肠病学，护士，临床健康心理学，营养，运动生理和生物医学信息。 2015年，CPS增加了NCI的数量（12）和自2011年以来的CCSG提交以来，同行评审的总审查（29）从6和24起资助。七个经过同行评审的赠款是多人奖励，从一项奖项中提高了。 NCI和全面同行评审的资金增加从$ 1,804,303和$ 6,244,484到$ 3,098,479和$ 11,890,377。从2012年至2015年，超过800名患者累计进行15次干预试验。这些试验中的十二例是研究者发起的，并进行了三个同行评审资助。堪萨斯州和密苏里州的成人肥胖率很高。这是许多CPS介入试验与集水区合作伙伴密切合作，专注于体育锻炼和减轻体重。 CPS 自2012年以来，成员已经发表了382篇文章，其中164篇（43％）具有概括性内部编程，127（33％）的文章已有典型间截图和204（54％）进行了机构间合作。 45个出版物（12％）有期刊影响因子≥8。CPS以重要的领导能力为KUCC做出了贡献（董事和三个广告，主席 PRMC，联合主席Swog Swog Swog委员会）和基于生物标志物的高度翻译早期阶段预防和生存试验经常进行平行动物研究。摇椅位置有助于移动有希望的钢琴进入更大的合作组试验。 KUCC通过共享资源为CPS做出了贡献和飞行员资金。将来，CPS将继续基于其新颖的癌前模型的优势，新的风险和响应生物标志物，早期试验的高风险队列，能量平衡和天然产品化学预防试验。 CPS将增加与CB的合作，以扩大生物标志物研究代谢组学，D3ET开发自然产物类似物，以进行初级预防，并使用CCPH 增加差异和集水区与与教育计划和心理的研究。