Powerful Solid-State Sources to Enable Advanced EPR and DNP-NMR Measurements

强大的固态源可实现先进的 EPR 和 DNP-NMR 测量

• 批准号: 9973197
• 负责人: Eric Bryerton
• 金额: $ 50万
• 依托单位: VIRGINIA DIODES, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-15 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9973197
• 关键词: 2,4-Dinitrophenol; Advanced Development; Amplifiers; Area; Biological; Biophysics; Cell division; Cells; Cellular biology; Communication; Disease; Electron Spin Resonance Spectroscopy; Electrons; Ensure; Foundations; Frequencies; Generations; Goals; Industry; Knowledge; Laboratories; Laboratory Research; Maintenance; Measurement; Mission; National Institute of General Medical Sciences; Nuclear; Nuclear Magnetic Resonance; Output; Performance; Phase; Physiologic pulse; Process; Proteins; Pump; Reporting; Research; Research Personnel; Sampling; Scheme; Signal Transduction; Small Business Innovation Research Grant; Source; Speed; Structure; System; Technology; Testing; Time; United States National Institutes of Health; Virginia; Weight; cold temperature; commercialization; cost; cryogenics; design; digital; experience; experimental study; falls; improved; interest; macromolecule; microwave electromagnetic radiation; millimeter; nanosecond; operation; prevent; research and development; solid state; success; tool; 2,4-Dinitrophenol; Advanced Development; Amplifiers; Area; Biological; Biophysics; Cell division; Cells; Cellular biology; Communication; Disease; Electron Spin Resonance Spectroscopy; Electrons; Ensure; Foundations; Frequencies; Generations; Goals; Industry; Knowledge; Laboratories; Laboratory Research; Maintenance; Measurement; Mission; National Institute of General Medical Sciences; Nuclear; Nuclear Magnetic Resonance; Output; Performance; Phase; Physiologic pulse; Process; Proteins; Pump; Reporting; Research; Research Personnel; Sampling; Scheme; Signal Transduction; Small Business Innovation Research Grant; Source; Speed; Structure; System; Technology; Testing; Time; United States National Institutes of Health; Virginia; Weight; cold temperature; commercialization; cost; cryogenics; design; digital; experience; experimental study; falls; improved; interest; macromolecule; microwave electromagnetic radiation; millimeter; nanosecond; operation; prevent; research and development; solid state; success; tool

Powerful Solid-State Sources to Enable Advanced EPR and DNP-NMR Measurements NIH SBIR Phase II Proposal VDI Project Summary/Abstract: DNP-NMR and EPR are important scientific tools that are of interest to the NIGMS Division of Cell Biology and Biophysics. They both rely on a high frequency microwave source to increase the polarization of electrons in the samples under test. In the past, progress in DNP-NMR and EPR has been hindered by the difficulty of generating sufficient power levels at the desired frequencies, which now extend well above 100 GHz. Typical systems rely on a Gyrotron oscillator that generates tens of watts of power. However, these systems are expensive to purchase and install, and even the operating and maintenance costs can be prohibitive. The key focus of this project is to advance solid-state (SS) source technology to the point where it can begin to replace the Gyrotrons for a significant proportion of DNP-NMR and pulsed-EPR measurements, thereby lowering the barriers to entry into this field and accelerating the pace of scientific discovery. The solid-state sources will also enable advanced modulation schemes that greatly improve the performance of EPR systems, and can potentially have a similar impact on DNP-NMR. The Phase I research achieved all of the proposal goals, including the demonstration of a more powerful 263 GHz source that was demonstrated to achieve significant DNP signal enhancement. The Phase II effort will build on this success in three ways; (i) the power level of the 263 GHz source will be further increased to facilitate a greater range of measurements, (ii) the technology will be extended to other frequencies of importance for EPR and DNP, specifically 395 and 527 GHz, (ii) the new sources will incorporate fast pulse capability as well as frequency and phase modulation, and (iv) the 263 GHz source will be developed to ensure easier operation by researchers who are not experts in millimeter wave technology; thereby accelerating the path to Phase III commercialization of this important technology.

强大的固态来源可实现高级EPR和DNP-NMR测量 NIH SBIR II期建议 VDI项目摘要/摘要： DNP-NMR和EPR是重要的科学工具，对NIGMS的攻击很重要 细胞生物学和生物物理学。他们都依靠高频微波源来增加 测试样品中电子的极化。过去，DNP-NMR和 EPR在所需的难度上难以产生足够的功率水平 频率，现在延伸远高于100 GHz。典型的系统依靠陀螺仪 产生数十瓦的振荡器。但是，这些系统很昂贵 购买和安装，甚至运营和维护成本也可能令人望而却步。钥匙 该项目的重点是将固态（SS）源技术提高到可以 开始替换大部分DNP-NMR和脉冲-EPR的陀螺素 测量结果，从而降低进入该领域的障碍并加速 科学发现。固态资源还将实现高级调制方案 大大提高了EPR系统的性能，并可能对 DNP-NMR。第一阶段研究实现了所有提案目标，包括演示 一个更强大的263 GHz源，该源被证明可以达到明显的DNP信号 增强。第二阶段的努力将以三种方式以这一成功为基础。 （i）功率水平 263 GHz源将进一步增加，以促进更大的测量范围，（ii） 该技术将扩展到EPR和DNP的其他重要频率， 特别是395和527 GHz，（ii）新来源也将包含快速脉冲功能 作为频率和相位调制，（iv）将开发263 GHz源以确保 不是毫米波技术专家的研究人员更容易的操作；从而 加速这项重要技术的第三阶段商业化的道路。