Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease

阻塞性睡眠呼吸暂停对阿尔茨海默病的发展很重要吗

基本信息

批准号：
9974144
负责人：
Atul Malhotra
金额：
$ 72.64万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9974144
关键词：
Acetazolamide Adherence Affect Aging Air Alzheimer&apos s Disease Alzheimer&apos s disease patient Alzheimer&apos s disease risk Amyloid Anatomy Apnea Arousal Brain Brain imaging Breathing Caring Clinical Clinical Research Clinical Trials Combined Modality Therapy Complex Data Deposition Development Dilator Disease Elderly Frequencies Functional disorder Future Genetic Genetic Markers Genetic Predisposition to Disease Hippocampus (Brain)Hypoxia Image Impairment Individual Intervention Link MRI Scans Medial Memory Memory impairment Methods Modeling Molecular Multiple Abnormalities Muscle Neurocognitive Neuropsychology Obstructive Sleep Apnea Outcome Oxidative Stress Oxygen Oxygen Therapy Care Pathogenesis Patients Pattern Pharmaceutical Preparations Population Positron-Emission Tomography Prevalence Prevention trial Publications Publishing Quality of life Risk Risk Factors Role Severities Sleep Sleep Apnea Syndromes Sleep Fragmentations Sleep disturbances Structure Subgroup Suggestion Symptoms Techniques Therapeutic Time Work apolipoprotein E-4 base brain dysfunction comparative effectiveness trial design disorder risk epidemiologic data epidemiology study experimental study high risk hippocampal atrophy improved indexing insight memory consolidation minimally invasive neuroimaging novel novel therapeutic intervention novel therapeutics older patient pre-clinical pre-clinical therapy predicting response pressure prevent primary outcome randomized trial recruit respiratory response tau Proteins theories therapeutic target

项目摘要

Project Abstract Aging is a known risk factor for the development of obstructive sleep apnea (OSA), although the underlying mechanisms are only recently being understood. OSA is associated with Alzheimer’s disease in epidemiological studies as well as having common genetic links. A number of mechanisms have been proposed including oxidative stress and amyloid and tau deposition which may contribute to the observed link. Recent prominent publications have hi-lighted the potential impact of sleep disruption on Alzheimer’s risk. We have clearly observed impairment in sleep-dependent memory consolidation even with mild OSA and have developed robust methods to assess these outcomes in a rigorous manner. Recent evidence suggests that OSA in older individuals may be a somewhat different disease than OSA in younger individuals, based on relatively unique underlying mechanisms. We have recently published and validated techniques allowing the assessment of the pathophysiology underlying OSA using minimally invasive methods making disease endotyping clinically accessible. We have also recently found subgroups of OSA patients who respond well to oxygen and can be predicted based on the underlying pathophysiology of OSA. We plan to study and further validate our model by assessing the impact of oxygen therapy in OSA patients who are at risk of developing Alzheimer’s disease. We have a robust panel of neurocognitive outcomes and have exciting preliminary data showing reversibility of some of the observed impairment in hippocampal memory. Moreover we are now working with expert imaging and neuropsychology collaborators who will help us define robust outcome metrics using MRI and PET scanning (e.g. volumetric analyses, amyloid, tau). Ultimately we hope that this application will lay the groundwork for a mechanistic comparative effectiveness trial whereby we can compare oxygen with standard therapy for select OSA patients in an effort to prevent the development of Alzheimer’s disease. Regardless of the results of the proposed work however we will gain major insights into the mechanisms and optimal care of elderly people with OSA.

项目摘要衰老是开发阻塞性睡眠呼吸暂停（OSA）的已知危险因素，尽管基础机制直到最近才被理解。 OSA与阿尔茨海默氏病有关流行病学研究以及具有共同的遗传联系。许多机制已经提出的包括氧化应激以及淀粉样蛋白和TAU沉积，可能有助于观察到的联系。最近的著名出版物已经启用了睡眠中断对阿尔茨海默氏症风险的潜在影响。我们即使使用轻度OSA，也明确观察到睡眠依赖性记忆巩固的损害开发了强大的方法来以严格的方式评估这些结果。最近的证据表明老年人中的OSA可能与年轻人的OSA有些不同，基于相关的独特基本机制。我们最近发表并验证了允许的技术使用最低侵入性的方法评估OSA的病理生理学的评估内型在临床上可访问。我们最近还发现了OSA患者的子组，他们对氧气可以根据OSA的潜在病理生理进行预测。我们计划学习并进一步学习通过评估氧疗法对有发展风险的OSA患者的影响来验证我们的模型阿尔茨海默氏病。我们有一个强大的神经认知结果面板，并具有令人兴奋的初步数据显示海马记忆中某些观察到的损伤的可逆性。而且我们现在与专家成像和神经心理学合作者合作，他们将帮助我们定义强大的结果指标使用MRI和PET扫描（例如体积分析，淀粉样蛋白，TAU）。最终，我们希望这个申请将为机械比较有效性试验奠定基础，我们可以将氧气与针对OSA患者的标准疗法，以防止阿尔茨海默氏病的发展。无论提出的工作的结果如何，我们都会对机制和 OSA老年人的最佳护理。