The human amygdala in social processing: circuits, physiology, behavior, and neuromodulation

社会处理中的人类杏仁核：回路、生理学、行为和神经调节

• 批准号: 9927864
• 负责人: Kelly Rowe Bijanki
• 金额: $ 14.82万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9927864
• 关键词: Address; Affective; Amygdaloid structure; Anatomy; Anxiety; Autonomic nervous system; Award; Basic Science; Behavior; Brain; Clinical; Clinical Research; Comorbidity; Data; Depressed mood; Depressive disorder; Development; Electric Stimulation; Electrical Stimulation of the Brain; Electrodes; Electrophysiology (science); Emotional; Emotions; Epilepsy; Evaluation; Evoked Potentials; Eye; Face; Facial Expression; Frequencies; Goals; Human; Implant; Implanted Electrodes; Knowledge; Major Depressive Disorder; Maps; Master of Science; Measures; Medical; Mental Depression; Mental disorders; Mentors; Mentorship; Mind; Monitor; National Institute of Mental Health; Neurons; Oligonucleotides; Operative Surgical Procedures; Patients; Performance; Physiologic pulse; Physiology; Play; Psychiatry; Reading; Refractory; Research; Research Ethics; Research Personnel; Research Training; Role; Seizures; Series; Statistical Models; Stratification; Structure; Symptoms; Synapses; System; Techniques; Testing; Time; Training; Treatment Protocols; Work; autism spectrum disorder; base; behavior measurement; comorbid depression; depressed patient; emotional stimulus; experience; experimental study; in vivo; neural circuit; neuroimaging; neuropsychiatry; neuroregulation; neurosurgery; novel; programs; research study; showing emotion; social; training opportunity

SUMMARY: The purpose of the current proposal is to enable the PI to transition to independent research investigator, with expertise in electrophysiological analysis techniques to examine the real-time function of the emotional (affective) system in neurosurgery patients who undergo the placement of depth electrodes for clinical purposes. The proposed training plan includes structured mentoring, hands-on training in electrophysiology, didactic coursework, and a rigorous proposed research study. The proposed experiments leverage a highly specialized experimental setting: human epilepsy patients with depth electrodes implanted in the amygdala – central to social and emotion processing – for routine seizure focus monitoring in medically refractory epilepsy. In this setting, we can record local neuronal activity as well as apply small electrical currents to stimulate for research purposes. The proposed training in electrophysiology will enable the PI to examine the real-time function of the amygdala, which, when paired with her existing expertise in human neuroimaging and psychiatric behavioral measurement, will allow a thorough comparison of amygdala activity in social processing between depressed and non-depressed patients. This project examines the hypothesis that the amygdala plays a direct and causal role in social processing deficits observed in depression. Within the NIMH Research Domain Criterion Framework, the current proposal examines the role of the amygdala in social processing from the level of neural circuits, physiology, and behavior, and to examine the potential for amygdala neuromodulation to enhance social processing. Deeper understanding of the neural circuitry of social processing will facilitate the study and treatment of depression with implications for broader neuropsychiatric conditions as well. Results of this project will provide pilot data for an NIMH R01 application, and compliment the ongoing work of the applicant and the mentorship team. Coursework will include didactic, and hands-on training in electrophysiological analysis, didactic training in advanced statistical modeling to build upon the applicant’s current training through the Masters’ of Science in Clinical Research program, and continued training in research ethics. Therefore, this award would allow the PI to accomplish her goal of becoming an independent, academic research investigator, while advancing the research objective of evaluating the causal role of the amygdala in social processing deficits in depression and the neuromodulatory potential of amygdala stimulation to reduce these deficits.

概括： 当前提案的目的是使PI能够过渡到独立研究 调查员，具有电生理分析技术的专业知识来检查实时 接受神经外科手术的患者情绪（情感）系统的功能 出于临床目的放置深度电极。拟议的培训计划包括。 结构化指导、电生理学实践培训、教学课程和 拟议的严格研究利用了高度专业化的研究。 实验环境：人类癫痫患者杏仁核植入深度电极 – 社交和情绪处理的核心 – 用于医学领域的常规癫痫焦点监测 在这种情况下，我们可以记录局部神经元活动并应用小信号。 电流刺激用于研究目的。 电生理学将使 PI 能够检查杏仁核的实时功能， 与她在人类神经影像学和精神病学行为方面现有的专业知识相结合 测量，将允许对社会处理中的杏仁核活动进行彻底的比较 该项目检验了抑郁症患者和非抑郁症患者之间的假设。 杏仁核在抑郁症中观察到的社会处理缺陷中起着直接和因果作用。 在 NIMH 研究领域标准框架内，当前提案审查了该角色 从神经回路、生理学和行为层面了解杏仁核在社会处理中的作用， 并检查杏仁核神经调节增强社会处理的潜力。 更深入地了解社会处理的神经回路将有助于研究和 抑郁症的治疗也对更广泛的神经精神疾病产生影响。 该项目的结果将为 NIMH R01 应用提供试点数据，并补充 申请人和导师团队正在进行的工作将包括教学，以及 电生理分析实践培训、高级统计教学培训 建模以申请人当前通过科学硕士学位的培训为基础 临床研究计划以及研究伦理方面的持续培训因此获得该奖项。 将使 PI 能够实现成为独立的学术研究人员的目标 研究者，同时推进评估因果作用的研究目标 杏仁核在抑郁症的社会处理缺陷和神经调节潜力中的作用 刺激杏仁核可以减少这些缺陷。