The human amygdala in social processing: circuits, physiology, behavior, and neuromodulation

社会处理中的人类杏仁核：回路、生理学、行为和神经调节

• 批准号: 9927864
• 负责人: Kelly Rowe Bijanki
• 金额: $ 14.82万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9927864
• 关键词: Address; Affective; Amygdaloid structure; Anatomy; Anxiety; Autonomic nervous system; Award; Basic Science; Behavior; Brain; Clinical; Clinical Research; Comorbidity; Data; Depressed mood; Depressive disorder; Development; Electric Stimulation; Electrical Stimulation of the Brain; Electrodes; Electrophysiology (science); Emotional; Emotions; Epilepsy; Evaluation; Evoked Potentials; Eye; Face; Facial Expression; Frequencies; Goals; Human; Implant; Implanted Electrodes; Knowledge; Major Depressive Disorder; Maps; Master of Science; Measures; Medical; Mental Depression; Mental disorders; Mentors; Mentorship; Mind; Monitor; National Institute of Mental Health; Neurons; Oligonucleotides; Operative Surgical Procedures; Patients; Performance; Physiologic pulse; Physiology; Play; Psychiatry; Reading; Refractory; Research; Research Ethics; Research Personnel; Research Training; Role; Seizures; Series; Statistical Models; Stratification; Structure; Symptoms; Synapses; System; Techniques; Testing; Time; Training; Treatment Protocols; Work; autism spectrum disorder; base; behavior measurement; comorbid depression; depressed patient; emotional stimulus; experience; experimental study; in vivo; neural circuit; neuroimaging; neuropsychiatry; neuroregulation; neurosurgery; novel; programs; research study; showing emotion; social; training opportunity

SUMMARY: The purpose of the current proposal is to enable the PI to transition to independent research investigator, with expertise in electrophysiological analysis techniques to examine the real-time function of the emotional (affective) system in neurosurgery patients who undergo the placement of depth electrodes for clinical purposes. The proposed training plan includes structured mentoring, hands-on training in electrophysiology, didactic coursework, and a rigorous proposed research study. The proposed experiments leverage a highly specialized experimental setting: human epilepsy patients with depth electrodes implanted in the amygdala – central to social and emotion processing – for routine seizure focus monitoring in medically refractory epilepsy. In this setting, we can record local neuronal activity as well as apply small electrical currents to stimulate for research purposes. The proposed training in electrophysiology will enable the PI to examine the real-time function of the amygdala, which, when paired with her existing expertise in human neuroimaging and psychiatric behavioral measurement, will allow a thorough comparison of amygdala activity in social processing between depressed and non-depressed patients. This project examines the hypothesis that the amygdala plays a direct and causal role in social processing deficits observed in depression. Within the NIMH Research Domain Criterion Framework, the current proposal examines the role of the amygdala in social processing from the level of neural circuits, physiology, and behavior, and to examine the potential for amygdala neuromodulation to enhance social processing. Deeper understanding of the neural circuitry of social processing will facilitate the study and treatment of depression with implications for broader neuropsychiatric conditions as well. Results of this project will provide pilot data for an NIMH R01 application, and compliment the ongoing work of the applicant and the mentorship team. Coursework will include didactic, and hands-on training in electrophysiological analysis, didactic training in advanced statistical modeling to build upon the applicant’s current training through the Masters’ of Science in Clinical Research program, and continued training in research ethics. Therefore, this award would allow the PI to accomplish her goal of becoming an independent, academic research investigator, while advancing the research objective of evaluating the causal role of the amygdala in social processing deficits in depression and the neuromodulatory potential of amygdala stimulation to reduce these deficits.

概括： 当前建议的目的是使PI过渡到独立研究 研究人员，具有电生理分析技术的专业知识，可以检查实时 情绪（情感）系统在神经外科患者中的功能 用于临床目的的深度电极的放置。拟议的培训计划包括 结构化的心理，动手培训在电生理学，教学课程和A 严格的研究研究。提出的实验利用了高度专业的 实验环境：植入杏仁核的人癫痫患者 - 社交和情感处理的中心 - 用于医学上的常规癫痫发作重点监测 难治性癫痫。在这种情况下，我们可以记录局部神经元活动并应用小 电流以刺激研究目的。拟议的培训 电生理学将使PI能够检查杏仁核的实时功能，该功能是，该功能 当与她在人类神经影像和精神病行为方面的现有专业知识配对时 测量，将允许对社会处理中的杏仁核活动进行详尽的比较 在抑郁和不抑郁的患者之间。该项目探讨了以下假设 杏仁核在社会处理中起着直接和因果作用，定义了在抑郁症中观察到的。 在NIMH研究领域标准框架内，当前的提案考试角色 来自神经回路，生理学和行为水平的社会处理中的杏仁核 并研究杏仁核神经调节以增强社会处理的潜力。 对社会处理神经回路的更深入了解将有助于研究和 对抑郁症的治疗也对更广泛的神经精神疾病有影响。 该项目的结果将为NIMH R01应用程序提供试验数据，并称赞 申请人和Mentalship团队正在进行的工作。课程将包括教学和 电生理分析，高级统计学的教学培训方面的动手培训 建模以通过申请人的当前培训来建立在科学硕士学位上 临床研究计划，并继续培训研究伦理。因此，这个奖项 PI将实现她成为一项独立的学术研究的目标 研究人员在促进研究目标的同时评估了 在抑郁症中的社会处理定义和神经调节潜力的杏仁核 杏仁核刺激以减少这些缺陷。